Brainlike cell bundles grown in a lab may expose some of the biological differences
of autistic brains.
Bundles of cells hint at biological differences
of autistic brains.
Although the effects evaporated after a day or two, the study shows for the first time that these parts
of the autistic brain «are not irretrievably broken,» Pelphrey says.
Gradually he built up a picture
of the autistic brain from infancy to adulthood, zeroing in on a crucial distinction between those who have autism and those who don't.
The mutated genes also interfered with how the brain's layers and halves relate to one another, a phenomenon confirmed by previous imaging studies
of the autistic brain.
Using interviews, blueprints, and accessible narrative, the author explains the workings
of the autistic brain while introducing the life of Temple Grandin, an autistic woman famous for her animal rights advocacy.
Not exact matches
Compounds produced in the digestive system have been linked to
autistic - type behaviour in laboratory settings, potentially demonstrating that what
autistic children eat can alter their
brain function, say scientists from the University
of Western Ontario.
Also, for parents
of potentially
autistic children or Adhd or other
brain diorders look up «Gut and psychology syndrome» with Dr. Natasha Campbell - McBride.
In Siegal's book The World
of the
Autistic Child, it was suggested that the sleep problems faced by autistic children may also be a result of the way autistic neurotransmitters in the brain f
Autistic Child, it was suggested that the sleep problems faced by
autistic children may also be a result of the way autistic neurotransmitters in the brain f
autistic children may also be a result
of the way
autistic neurotransmitters in the brain f
autistic neurotransmitters in the
brain function.
As the
autistic brain grows in the womb, it bursts with an overabundance
of neurons.
STOP SIGNS Brainlike structures grown from
autistic patients» stem cells (right) produced greater numbers
of brain cells that make other
brain cells less active (green and red) compared with structures grown from the cells
of a non-
autistic family member (left).
Miller has also seen physiological similarities in the
brains of autistic savants and patients with frontotemporal dementia.
Imaging studies have shown that when
autistic children see a familiar face, their pattern
of brain activation is different from that
of normal children.
The abnormality thus detected consists in a less deep fold in Broca's area, a region
of the
brain specialized in language and communication, functions that are impaired in
autistic patients.
For a paper published in the International Journal
of Psychophysiology, the researchers observed the EEG measures
of 13
autistic children and 13 neurotypical children (children with a mean age
of 10 years old without an intellectual deficiency or sleep problem and who were not on medication) and found that disruptions in protective
brain waves during sleep are associated with lower results on verbal IQ tests.
Autistic toddlers tend to have large
brains for their age, and researchers have shown a correlation between the degree
of excess growth and the severity
of autism symptoms.
The authors suggest that the intricate balance between the signaling
of neurons in these three
brain regions may be crucial for normal social behavior in humans, and that disruption may contribute to various psychiatric conditions, including
autistic spectrum disorders.
Situations that are normally socially rewarding fail to activate
brain - reward circuitry in
autistic children, Izuma adds, so they may also find the idea
of a good social reputation less rewarding.
Instead
of changing to accommodate a job, connectivity in key
brain networks
of autistic children looks similar to connectivity in the resting
brain.
These are the accumulated reflections from a lifetime spent observing the extraordinary ways the human
brain can misfire and misbehave: a man who believes his own leg does not belong to him, an
autistic woman with a gift for understanding animals, and the man who mistook his wife for a hat — the case that inspired one
of Sacks's most famous books.
The involvement
of this enzyme in susceptibility to oxidative stress, which has frequently been observed in
autistic children, its association with gastrointestinal diseases — which often accompany
autistic disorders — and its role in nerve development and neurotransmission mean it is an ideal candidate for deregulation
of its expression to lead to the abnormal
brain development observed in ASD.
«We had
brain tissue from
autistic individuals as young as 5 and as old as 45 and we found neuroglial inflammation in all
of them.
Courchesne suspects that fetal
brains become
autistic due to a combination
of genetic and environmental influences that strike during the second and possibly third trimesters, just as neurons are dividing.
As they develop,
autistic brains bloom with an overabundance
of neurons, Courchesne finds.
The extra neurons in the
autistic brain probably send out a vast number
of extra connections to other neurons.
When
autistic children are born, Courchesne's research suggests, they have an abundance
of neurons jammed into an average - size
brain.
Past that age, Courchesne found, the rate
of brain growth slowed in
autistic children, falling behind that
of ordinary children.
In a 2005 study in the Annals
of Neurology, he found inflammation in immune - responsive
brain cells
of autistic patients.
Working with the
brains of six normal children and seven
autistic children ages 2 to 16, most
of whom died
of drowning, Courchesne has studied neurons under the microscope and even counted the number
of neural cells in different tissue samples.
«New studies point to autism beginning in the womb,» said Courchesne, who, with colleagues, published one such widely reported study last year detailing disrupted
brain development in post-mortem
brains of autistic children.
This lack
of interest in human speech not only correlated with the severity
of a child's
autistic symptoms, Kuhl notes, but with a lack
of typical
brain response to subtle changes in syllables, such as the switch from «ba» to «da.»
The most interesting thing about the results, she says, was not the correction
of the
autistic symptoms in the mice, but the clues the study provided about how the gut's microbial population may affect the
brain and behavior.
One theory
of autistic savantism suggests that during fetal development or early in life, some developmental abnormality affects the
brain's left side, resulting in the difficulties that many
autistic people have with words and social interaction, functions typically processed by the left hemisphere.
Functional imaging studies have also shown that
autistic minds show decreased activity and connectivity in areas
of the so - called «social
brain» — regions important for language, face recognition and emotion.
A team
of scientists at the University
of Cambridge has discovered that specific genes are linked to individual differences in
brain anatomy in
autistic children.
Interestingly, many
of the genes identified in this study have been shown to have lower gene activity at the molecular level in
autistic post mortem
brain tissue samples.
Six
of the 7 cases in the
autistic group had neuron counts that met or exceeded the regression line
of those in the control group, indicating that they had as many or more neurons than would be predicted from their large
brain weights.
«We discovered gene - related disruption
of circuits that connect the
autistic brain's layers and hemispheres to each other,» explained Geschwind, who is director
of the UCLA Neurogenetics Program and the Center for Autism Research and Treatment and co-director
of the Center for Neurobehavioral Genetics at UCLA.
A May study in Nature found that 65 percent
of autistic children share a set
of mutations that may regulate genes known to influence communication among
brain cells.
The 1
autistic child with a
brain size within the 95 % CI
of controls had among the greatest prefrontal neuron counts in the study, which raises the question
of whether excess prefrontal neuron counts may be present in other
autistic children who have near normal or smaller
brain sizes.
However, the neural basis
of early overgrowth remains unknown and can only be known from direct quantitative studies
of the young postmortem
autistic brain.
Also, our sample
of autistic cases had
brain weights typical
of brain weights in larger postmortem samples
of autistic children.
«It is this divide in language skills and use, which mirrors the opposite social profiles, that led us to explore how
brains of individuals with Williams syndrome and
autistic spectrum disorders process language,» says Fishman.
On the other hand, dysfunctional speech - related neural processing in the
autistic brain might also denote a deficiency
of oscillation coordination, based on temporal integration deficits, that reaches beyond the auditory modality.
Researchers at four study sites nationwide used a type
of MRI scan to look at
brain development in the younger siblings
of autistic children, who are known to be at higher risk for autism themselves.
Although there is substantial evidence from neuroimaging studies that the
brain of a child with autism is undergoing abnormal development, little is known about the underlying cellular, molecular and genetic mechanisms that lead to the onset
of autistic symptoms.
Researchers have found that some mothers
of autistic children create antibodies to the
brain tissue
of their fetus, meaning the child is a born with a
brain already developmentally imbalanced by immune destruction.
Supplements
of omega 3 fatty acids or foods high on this nutrient is also recommended to
autistic people as it is deficient in their case and hence can help their
brain and bodily functions.
With the use
of vitamins and other nutrients,
autistic children can achieve higher
brain function, improvement in sleep patterns and an increase in the function
of the immune system.
What can we discover about the
brains of autistic children that can help their teachers and parents?