Specific focus is placed on developing a comprehensive understanding
of autografts, allografts, synthetics, xenografts, and bone morphogenic proteins.
Using an approach developed at Maisonneuve - Rosemont, consisting
of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.
This is the closest anyone has ever been to equaling the efficacy
of an autograft, and we did it with nothing more than a tube and the recruitment of the body's own immune system.»
Not exact matches
This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part
of the athlete's knee and transplanting it into the defect (osteochondral
autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).
«Eight
of the 13 high - risk patients treated with the
autograft system experienced much faster healing
of their chronic wounds,» said Litt, who also serves as medical director
of MU Health Care's burn and wound program.
In the study, Litt's team at MU Health Care used a recently developed
autograft harvesting system to care for 13 patients with various types
of chronic wounds.
With respect to techniques used for ACL reconstruction, patients who had a patellar tendon
autograft had an increased chance
of getting back to their activity.
Overall, the
autograft strategy followed by allograft resulted in relapse - free survival rates
of 20 - 25 % in the long term.
But despite efforts to find the optimal combination
of tube material, growth factors, proteins and other helpers, nothing has come close to matching the
autograft's success.
The current standard
of care, called an
autograft, involves surgically removing a less important nerve, like the one running down the back
of the calf, and grafting it into the damaged area.
Or, at least, that's how it should work — unlike in an
autograft, stem cells don't always turn into the needed bone or cartilage because
of the scaffolds» material makeup.
The idea is, a patient would come in with a nasty broken bone — say, a shattered jaw — and instead
of going through painful
autograft surgeries or waiting for a custom scaffold to be manufactured, he or she could be x-rayed and a 3D - printed hyperelastic bone scaffold could be printed that same day.
The most common option is an
autograft, where a piece
of bone is taken from a patient's own body, usually from a hip or a rib, and implanted where it's needed elsewhere in that same patient's skeleton.
A new study highlights the potential for meshed
autografts and adipose stem cell - laden hydrogels in wound healing in an animal model
of human burn injuries
Now, a team led by Robert J. Christy (United States Army Institute
of Surgical Research, JBSA Fort Sam Houston, Texas, USA) has assessed a combination
of meshed
autografts and ASC - laden hydrogels to promote wound healing in a porcine model [4].
Examples
of such carrier systems that have been used with success with BMDMSC include: absorbable collagen sponge, absorbable gelatin sponge or powder,
autograft cancellous bone, allograft cancellous bone,
autograft and / or allograft corticocancellous bone, autologous bone marrow and any combination
of these carriers (Photo 6).
In
autograft the tumor site is removed from the leg and then treated with a high dose
of radiation to «kill» the tumor.