Sentences with phrase «of autoimmune response»

One target of this autoimmune response is tissue transglutaminase (tTG), an enzyme that modifies a component of gluten (gliadin) to a form that more strongly stimulates T cells.

In their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodies.

With what we've recently come to understand in terms of the autoimmune response in type 1 diabetes, to what degree do you think this knowledge will be more generally applicable to other autoimmune diseases such as Crohn's and lupus?

The Bristol group has now revealed how the administration of fragments of the proteins that are normally the target for attack leads to correction of the autoimmune response.

Errors in the interpretation of the signals that the tissue sends to the immune cells are the basis of defective wound healing and play a still poorly defined role in the establishment of autoimmune responses and in the most common pregnancy complications, such as recurrent abortion, preeclampsia and intrauterine growth restriction.

Not exact matches

In celiacs, gluten triggers an autoimmune response whose effects include gastrointestinal distress, chronic fatigue, anemia, osteoporosis, depression and even a heightened risk of intestinal cancer.

Gluten sensitivities cause an autoimmune response that attacks the lining of the small intestine.

However, these same inflammatory responses can become part of a disease if they mistakenly target the body's own cells, such as occurs in the case of autoimmune conditions like Crohn's disease.

The scientists zeroed in on a type of immune cell called regulatory T - cells, which were known to suppress autoimmune responses.

«If we learn how to control dendritic cells, we could strengthen our immune response to infection when needed, or weaken the action of certain immune cells that attack the body's own tissues in autoimmune disease.»

But Acinetobacter also ramped down the production of regulatory T cells, which help prevent autoimmune diseases by dampening the immune response.

Over the course of several visits, Bolte studied Palmer's food diaries and helped him nail down which foods were most likely to trigger the painful autoimmune response.

We are currently working with Linda Bradley, Ph.D., professor in the Immunity and Pathogenesis Program, and co-author of the study, to couple our approach with an approach to reining in the autoimmune response,» added Levine.

Dr. Joaquín Espinosa is enthusiastic about the results of his study, «The constant activation of the Interferon response could explain many aspects of Down syndrome, such as cognitive deficit, stunted growth, increased prevalence of autoimmune disorders, high risk of Alzheimer's disease, and protection against solid tumors.»

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body; in other words, the body attacks its own cells.

For example, some cases of multiple sclerosis are thought to result from autoimmune activity in response to an infection in the central nervous system and cerebrospinal fluid.

The researchers tested these cells on a batch of mice that had been injected with myelin basic protein, which triggers the autoimmune response and causes EAE symptoms to occur in about 2 weeks.

An insufficient or overactive immune response is at the heart of countless pathologies including cancer, autoimmune diseases, and infectious diseases.

The answer is complicated, he adds, but much of it involves a delicate balancing act among elements of the immune system: while immunity protects us against disease, an overly aggressive immune response may trigger dangerous, even life - threatening, autoimmune reactions in which the body attacks itself.

A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS).

In the trial, 18.1 % of people taking alemtuzumab experienced thyroid - related autoimmune responses, and 0.8 % developed the potentially life - threatening condition immune thrombocytopenia.

This jump - started cell division is called immune cell activation and is an important component of both normal immune responses and autoimmune reactions.

Although it has been suggested that resveratrol has anti-inflammatory properties, in this study resveratrol did not suppress autoimmune responses as measured by levels of MOG35 -55-specific lymphoproliferative responses and pro-inflammatory cytokine production.

And after decades of puzzling over what causes narcolepsy's fits of daytime sleep and muscle paralysis, researchers suspect it's a response to an autoimmune disease.

This incompletely inactivation of genes on the X chromosome, including many immunity - related genes, may help explain why females are predisposed to many autoimmune conditions and also have stronger immune responses than males.

«Because JAK3 has such an isolated role in the immune system, we believe that inhibiting it will lead to a suppression of immune responses which could be used to treat autoimmune disorders like psoriasis and rheumatoid arthritis.

Previous research has indicated that salt may alter the autoimmune response, which is implicated in the development of multiple sclerosis (MS), but it is not clear if it has any direct effect on the course of the disease itself.

Because these islets carried the kind of peptide that spleen cells use to reeducate the immune system, they were able both to control blood sugar and to end the autoimmune response.

Why the disease has such a wide range of effects isn't completely understood, but in recent years a potential cause — the loss of hormone - producing neurons, possibly through an autoimmune response — has been identified.

«This «standby» mode lowers the immune response threshold, which is helpful in fighting an infection, but could also set the stage for an autoimmune disease where the immune responses are out of control.»

This autoimmune response may contribute to the progression of the disease, the researchers report online June 21...

These signals prompt a cascade of defenses designed to kill the pathogen; however, in a person with autoimmune disease, these inflammatory responses inexplicably turn against normal tissue.

Researchers from the Perelman School of Medicine at the University of Pennsylvania recently found a shared genetic link in the autoimmune response among PV patients that provides important new clues about how autoantibodies in PV originate.

In an experimental model of type 1 diabetes and in the humanized model, this treatment resulted in a significantly lower autoimmune response.

In recent years, researchers have successfully countered autoimmune diseases like rheumatoid arthritis by suppressing the immune response with antibodies engineered to stop the action of TNF - a.

Up to now research has often viewed autoimmune disease as the result of immune system hyperactivity, yet recently it has become increasingly clear that such ailments may also result from an immune system those responses are too weak.

Displaced bacteria can activate autoimmune responses and inflammation, which are known to be associated with the onset of depression, lower mood and fatigue.

It included a 1994 report from the Institute of Medicine that said it was biologically plausible for a vaccine to «induce... an autoimmune response... by nonspecific activation of the T cells directed against myelin proteins.»

One way to improve autoimmune response is to use nanotechnology to encourage the growth of health - enhancing microbiomes in homes and schools.

The Joslin scientists will study the effects of introducing various strains of gut bacteria that may increase or decrease inflammatory responses that may fuel the autoimmune reaction.

Rarely, immunotherapy will trigger a severe autoimmune response that can cause inflammation of the liver, lungs, or colon.

«It's the first time we can really prove that a vaccine or an immune response can trigger an autoimmune disease,» says Emmanuel Mignot, director of Stanford University's Center for Sleep Sciences and Medicine.

The scientists speculate in their PNAS article, «the Ro autoantigen may not be simply a passive target in the lupus immune response but, instead, may be important for the prevention of autoimmune disease.»

Understanding the exact mechanisms of immunity and immune response will allow for new treatments for autoimmune and immune - related disorders.

The decline of the immune system with age (immunosenescence) is reflected in the increased susceptibility to infectious diseases, poorer response to vaccination, increased prevalence of cancer, accelerated aging (frailty), autoimmune and other chronic diseases.

The laboratory has investigated the roles of these molecules in inflammatory and autoimmune diseases to determine if modulating their activity alters the immune response and may be useful for therapeutic intervention.

ß1 - Adrenergic Receptor Contains Multiple IAk and IEk Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A / J Mice.

These kinds of inflammatory responses have been linked to diabetes, heart disease and a variety of autoimmune disorders.

In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.

• In nutrigenetics, the aim is to understand how genetic makeup determines response to diet and susceptibility to diet - related disease — i.e., a number of genetic variations have been shown to increase the susceptibility to Type 2 diabetes, obesity, cardiovascular diseases and some autoimmune diseases and cancers.