Sentences with phrase «of available tissue»

They can be a challenge to close because of a scarcity of available tissue to lap over the defect.

Analysis of the hospitalized group was not possible owing to the lack of available tissue (n = 3).

This partition is performed in such a way that we try to keep a similar underlying distribution of the number of available tissues per individual both for the training and testing datasets.

Increasing tension through max contraction of all available tissues carries deep into the core, getting the little stabilizers involved.

Not exact matches

When such a condition occurs in a male, the easiest form of plastic surgery by far, with a view to correcting the abnormality and gaining a cosmetically satisfactory appearance, is to remove all the male parts, including the testes, and to construct from the tissues available a labial and vaginal configuration.

The challenge is substantial — the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus repository (GEO) alone contains 80,985 public datasets, spanning hundreds of tissue types in thousands of organisms — and the rapid growth in data makes it difficult for journals or data repositories to «police» whether datasets that should be made publicly available actually are.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Dr Brastianos will say: «When brain metastasis tissue is available as part of clinical care, we are suggesting sequencing and analysis of that sample.

Although some TIC - targeting antibodies are available, there is not a single universal antibody which covers all kinds of TICs from different tissues.

Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.

They are very important in medicine — most medications available now are small molecules — as well as in biology as probes to uncover the inner workings of cells and tissues.

Then we need to publicize the role of the bank within the biomedical research community so that they know tissues may be available.

The authors acknowledge that «tumor tissue should be considered the preferred sample type when available, however, our encouraging results suggest that a single plasma - derived ctDNA sample may be considered appropriate for assessment of EGFR mutation status when tumor tissue is unavailable or exhausted.»

MakerBot has also supplied the Feinstein Institute with early samples of its just - announced MakerBot PLA Composite Filaments in Limestone (calcium carbonate) and Iron, which will be available commercially later this year, so the Feinstein Institute can start investigating how to engineer other kinds of tissue, like bone or 3D print custom - made shields for cancer and radiation treatment.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

Virtual surgery used in this manner has also been limited by technology, as most computers available to surgeons for this work can do little more than render relatively crude images of tissue, muscles and organs.

This reduces the concentration of oxygen available in the tissue, which may aggravate conventional PDT.

Now Yamanaka and his colleagues report in the journal Cell that the same combination of genes induced pluripotency in commercially available human fibroblasts (connective tissue cells that play a crucial role in healing) derived from the facial skin of a 36 - year - old woman, the joint tissue of a man, aged 69, and a newborn, respectively.

This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone.

The technique of using sodium ions in the body as a biomarker for imaging is very challenging because of the lower detectability of the sodium signal in biological tissue by currently available MRI scanners.

«Given the limited number of successful therapies available today for repairing lost tissues, we need to look to animals like zebrafish for new clues about how to stimulate regeneration.»

«The ability to suture a thread - based diagnostic device intimately in a tissue or organ environment in three dimensions adds a unique feature that is not available with other flexible diagnostic platforms,» said Sameer Sonkusale, Ph.D., corresponding author on the paper and director of the interdisciplinary Nano Lab in the Department of Electrical and Computer Engineering at Tufts University's School of Engineering.

Unfortunately, organs aren't always available, and recipients win a second chance at life only through luck - of - the - draw tissue compatibility.

Najafabadi and McGill graduate student Rached Alkallas then applied the mathematical method to analyze publicly available data on the brain tissues of people who died from Alzheimer's.

Of 191 workers with available CT scans, 53 percent had asbestos - related changes of the tissue lining the lungs (pleura), while 13 percent had changes of the lung substance (parenchymaOf 191 workers with available CT scans, 53 percent had asbestos - related changes of the tissue lining the lungs (pleura), while 13 percent had changes of the lung substance (parenchymaof the tissue lining the lungs (pleura), while 13 percent had changes of the lung substance (parenchymaof the lung substance (parenchyma).

Using a very sensitive DNA analysis technique that can also be employed when only very small amounts of DNA from old tissue are available, the researchers could compare the two current cell lines with the tumor from which the cell line was established.

Depending on the tissue type and what jobs that tissue is doing, distinct portions of DNA are unspooled to become available for activity through a structure called open chromatin, said Gregory Crawford, an associate professor of pediatrics and expert on gene expression.

A study in rats published August 25 in Cell Reports suggests that a different approach that targets delta opioid receptors on sensory neurons in peripheral tissues might avoid the side effects and high abuse potential of currently available pain relievers.

«It is the best source of fresh human brain tissue available at the moment,» says Jucker, who plans to scrutinize it carefully under the microscope for anything that might resemble tiny clumps or seeds of amyloid - β.

Although Khaitovich thinks that the Neandertal genes affect the composition of fat throughout the body, the researchers focused on brain tissue first because it contains so many fatty acids — and was available from a brain tissue bank.

Total RNA was extracted from the perigonadal (epididymal or parametrial) adipose tissue of individual mice using a commercially available acid - phenol reagent (TRIzol; Invitrogen Corp., Carlsbad, California, USA).

Fixation of tissues via thoracotomy is also available to investigators.

The major goal of the Animal Models and Cell Isolation Core will be to make available to members of NOAC tissue and cellular samples from control and ethanol - exposed animals.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

If data are available, use physiological studies of dominant corals to assess likely resistance and tolerance based on zooxanthellae type, photo - protective pigments, or tissue condition (lipid levels), and / or heterotrophic capacity.

Limited information is available for metabolic profiles of eye tissues, and the mechanistic links between RPE metabolomics and retinal degeneration are yet to be determined.

Similar to other Unyvero Applications, Unyvero UTI allows the rapid detection of pathogens and genetic resistance markers in a broad range of routinely available patient sample types, such as midstream urine, catheter urine, suprapubic aspiration, and tissue.

Patients often have available tissue blocks from nephrectomy specimens, but not from metastatic sites for analysis of biomarker expression, yet metastatic specimens are typically treated with systemic therapy, after nephrectomy.

In a disease where human tissue is an essential resource, standardisation of cell lines and making them available to the community is incredibly important.

WISH The ideal way to do this kind of analysis would be with large family data sets with diverse tissue types, so that the researchers know the parental genotypes, but Lappalainen says only data sets from blood samples are currently available.

[25] Seeing that in metastatic patients the only available tumor is often core biopsies rather than whole tissue blocks, we next attempted to determine whether the degree of heterogeneity varies between primary and metastatic sites, using the TMA cores as surrogates for core biopsy specimens.

Researchers suggest that this liver tissue could be used in place of donor organs during liver transplantation or during the bridge period until a suitable donor is available for patients with acute liver failure.

In this document, openly available for download, we provide an overview of the effort; our framework for the first draft of the atlas; descriptions of the technology and data analysis tools available to build the atlas; an introduction to the Data Coordination Platform that will host the data for researchers worldwide; a deeper look at biological systems we plan to explore and map; and details on the organization and governance of the HCA consortium and its relationships to the public (including ethical considerations regarding organ and tissue donors) and to funding support.

Gene mutation data were available for 73 and 52 patients of the training and validation cohorts with available tissue samples, respectively (Figure 1A).

In fact, the FDA has recommended that newer technologies be employed as soon they become available, to reduce the possibility of very serious off - target effects of therapeutic antibodies that bind to antigens in non-target tissues.

To make available a centralized resource of standard operating procedures and protocols used by our networked sites in the acquisition, preparation, and distribution of tissue

A White Paper, openly available for download, provides an overview of the effort; our framework for the first draft of the atlas; descriptions of the technology and data analysis tools available to build the atlas; an introduction to the Data Coordination Platform that will host the data for researchers worldwide; a deeper look at biological systems we plan to explore and map; and details on the organization and governance of the HCA consortium and its relationships to the public (including ethical considerations regarding organ and tissue donors) and to funding support.

The protein atlas now also includes a Dictionary that aims to facilitate the interpretation and use of the image - based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding tissue histology, pathology and cell biology.

To do this, scientists will examine part of the more than 30 tissue types available, which were collected through autopsies or organ and tissue transplant programs.

The remaining brain and spinal cord tissue will be banked and made available for future NIH - sponsored studies of the central nervous system.