Sentences with phrase «of avermectins»

Those dogs are not only more prone to be sensitive to ivermectin; they tend to be sensitive to the entire family of avermectins which includes many of the drugs veterinarians use to treat parasites.

Perhaps the biggest contribution of the discovery of avermectins in veterinary medicine is the prevention of heartworm disease, which is nearly 100 % preventable with monthly micro-doses of these compounds available in any number of commercial products.

Since it does not readily cross in to the brain of most dogs (with exceptions), pets tolerate doses of avermectins that kill the larval stages of heartworms.

Congratulations to William C. Campbell, Ph.D., who has been jointly awarded this year's Nobel Prize in Physiology or Medicine for the discovery of avermectin, which led to a treatment for river blindness.

KENILWORTH, N.J. --(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, proudly congratulates William C. Campbell, a retired scientist from Merck Research Laboratories, who was jointly named the 2015 Nobel Prize winner in Physiology or Medicine with Satoshi Omura for the discovery of avermectin, which led to Merck's development of Mectizan (ivermectin), a treatment for river blindness (also known as onchocerciasis) in Africa, Latin America and Yemen.

It began with the recognition that one of the avermectin derivative compounds, ivermectin, was effective in treating Onchocerca volvulus, the worm parasite responsible for causing River Blindess, a disease that is spread by the bite of the black fly and infects 16 million people a year world wide.

Ivermectin and other derivatives of avermectin have proven to treat countless worm and other parasites in both human and veterinary medicine.

The amount of body fat that the dog possesses is likely to affect the dynamics of the avermectin in their body (ref).

Not exact matches

On Monday, the 2015 Nobel Prize in Physiology or Medicine went to William Campbell of Drew University in Madison, New Jersey, and AAAS member Satoshi Ōmura of Kitasato University in Tokyo, who will share half the prize for discovering the drug avermectin, which has been used to treat river blindness and lymphatic filariasis as well as other parasitic diseases.

Doramectin — Doramectin, another avermectin, has been used in a study involving 23 dogs that received weekly subcutaneous injections of 600 µg / kg.10, 31 None of the animals showed adverse effects with doramectin; however, this drug should not be used in ivermectin - sensitive breeds of dogs.

Macdonald N, Gledhill A. Potential impact of ABC ± (p - glycoprotein) polymorphisms on avermectin toxicity in humans.

Heartworm preventatives belong to a family of drugs called the avermectins.

Of the current heartworm medications, all contain avermectins except Interceptor / Sentinel (Novartis) which contained a closely related compound, milbemycin oxime.

In that article, the author relies on a concept called «refugia» or selection pressure, to explain why heartworms are unlikely to develop the resistance to avermectins that is occurring in the parasites of livestock.

With this ten-fold increase in incidence of the problem, I am very concerned that the parasites are becoming resistant to the avermectins (EVERY heartworm preventive on the market except for Sentinel and Interceptor) and to milbemycin oxime (the active ingredient in Sentinel and Interceptor).

Some of the other topical flea and heartworm control avermectin products will probably also prevent sarcoptic mange — but they are not currently approved for that use in the United States.

Certain medications the dog might be receiving concurrently (spinosad / Comfortis ®, antifungals medications like itraconazole and ketoconazole, certain antibiotics, corticosteroids, Apoquel ® / oclacitinib, etc.) can make a bad reaction to the avermectins more likely You can read more on the subject of demodectic mange treatment here, here, here and here.