Sentences with phrase «of axon regeneration»
In Aim 2, we will examine whether the rate and pattern of axon regeneration in these knockout mice are affected.
https://www.glaucoma.org/
Paxillin phosphorylation counteracts proteoglycan - mediated inhibition of axon regeneration.
The study, «Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits,» which has been published in The Journal of Cell Biology, suggests potential new strategies to stimulate the regrowth of human neurons damaged by injury or disease.
Not exact matches
But exploring the role of PPM - 2 in controlling DLK - 1 and axon regeneration could be worthwhile — and could have implications in neurodegenerative diseases.»
The study describes how RPM - 1 regulates the activity of a single protein known as DLK - 1, a protein that regulates neuron development and plays an essential role in axon regeneration.
«This clearly refuted the assumption that getting rid of scars would permit spontaneous regeneration of injured axons,» Sofroniew said.
Sheng and his research fellow Bing Zhou, the first author of the study, initially found that when mature mouse axons are severed, nearby mitochondria are damaged and become unable to provide sufficient ATP to support injured nerve regeneration.
We are further exploring the molecular network in which the Tsc proteins function, and have found that modulation of the growth - promoting mTOR pathway, which is regulated by TSC proteins, can promote axon regeneration in the adult central nervous system.
During his doctoral and post-doctoral work under the mentorship of Jeffrey Goldberg, MD, PhD, and Larry Benowitz, PhD, Dr. Trakhtenberg discovered (1) how Set - β and PP2A proteins regulate axon growth; (2) the role of serotonin receptor 2C in neurite growth and processing of visual information; and (3) that inhibiting the transcription factor Klf9 acts synergistically with zinc chelation in stimulating axon regeneration.
Our approach is innovative in that we propose to study a novel group of bioinformatically - predicted factors, which we hypothesize cooperate in controlling RGC axon growth and regeneration.
They promote regeneration of those axons.
What his group found is that not only does that promote axon regeneration all the way back down the nerve, but in fact those axons go back to the right areas that they're supposed to get to in the brain — the right brain nuclei — and restore some measures of visual function.
Summary: Poor regeneration and reconnection of retinal ganglion cell (RGC) axons is a major obstacle for treating ocular trauma and diseases including glaucoma.
Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury.
The Yale team found more than 580 different genes that may play a role in regeneration of axons in nerve cells, something that rarely occurs in adult mammals but is of vital interest to scientists hoping to repair injuries to the central nervous system.
The researchers also reported that eliminating one of those genes, Rab27, led to regeneration of axons in the optic nerve or spinal cord of mice.
His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.