UCLA scientists used DropSynth to make
thousands of bacterial genes with different versions of phosphopantetheine adenylyltransferase, or PPAT (pictured).
Fierer adds that it may be possible to retrieve useful amounts
of bacterial gene sequences from textured surfaces that won't yield fingerprints.
Ten
sets of bacterial genes have similar, newly discovered defense roles, researchers report online January 25 in Science.
Nine
groups of bacterial genes turned out to be antiphage defense systems, and one system protected against plasmids, another source of foreign DNA, the researchers found.
The structures of the halogenated compounds synthesized by seaweeds are similar to those of these substances so that they cause a blockade of the bacterial receptors and suppress the
switchover of bacterial gene regulation to biofilm formation.
Here's why: When the
DNA of a bacterial gene is being transcribed into RNA, and the molecular machinery of transcription gets stuck at a bulky adduct, Mfd appears on the scene, recruits other repair proteins that snip away the damaged section of DNA, and «un-sticks» the transcription machinery so that it can resume its work.
The message seems clear: antibiotics are losing their magic touch after decades of incautious prescription, improper use and the inevitable
spread of bacterial genes that confer drug resistance.
In previous research, Grice and colleagues illuminated the great diversity of bacteria living on the skin using DNA - based sequence
analysis of bacterial genes.
If the
rhythm of bacterial genes being transcribed was set to music, it might sound like the asymmetric beat of Bartok, a favorite composer of structural biologist and pianist Seth Darst.
The genomes of bacteriodes and enterococcus reinforce something scientists have been concerned about for years: the remarkable
fluidity of the bacterial gene pool.
A
pair of bacterial genes may enable genetic engineering strategies for curbing populations of virus - transmitting mosquitoes.
To show that technique worked, the scientists used DropSynth to make
thousands of bacterial genes — each as long as 669 base pairs in length.