Triclosan: Its efficacy as an antimicrobial agent, the
risk of bacterial resistance and its possible role in disrupted hormonal development remain controversial.
Overuse of antibiotics leads to the
development of bacterial resistance and puts patients at risk for serious infections such as severe diarrheal infection due to Clostridium difficile (C Diff).
The natural human antimicrobial peptide LL37 and the colistin drug each inhibited growth of about 50 percent of the clinical isolates, indicating a high
level of bacterial resistance to these drugs.
But because antibiotics are expensive to develop and don't make much money (after all, over-prescribing simply speeds up the
formation of bacterial resistance), true innovation comes rarely.
For instance, LA and the derivative monolaurin were reported to destroy cell membranes of gram - positive bacteria and lipid - coated viruses, to interfere with main cellular responses as the activation of transduction cascades and gene transcription, to stabilize cell membranes toward the
prevention of bacterial resistance.
Tetracycline use is decreasing due to increasing
incidences of bacterial resistance; however, but many doctors still use them with acne, UTIs, as well as respiratory tract infections.
The problem was likely to have been caused by the plumbing changes or improperly maintained cisterns, opening the
risk of bacterial resistance to disinfectants.