Chang X, Wang Z, Zhang J, Yan H, Bian H, Xia M, Lin H, Jiang J, Gao X. Lipid profiling of the therapeutic effects
of berberine in patients with nonalcoholic fatty liver disease.J Transl Med.
In a small study, 9 adults with prediabetes who took 900
mg of berberine daily for 3 months had significant reductions in weight, belly fat, cholesterol, triglycerides and blood pressure (191, 192).
Currently researchers are looking at the benefits
of berberine on fertility and insulin sensitivity in women with PCOS.
No data are available regarding the
safety of berberine in long - term use in young women or in early pregnancy.
Some of the drugs that these enzymes detoxify are tricyclics, MAOIs, SSRIs, opiates, anti-arrhythmics, beta - blockers, Cimetidine, Coumadin, sulfonylureas and most steroid hormones.The
use of berberine during pregnancy is contraindicated.
The use
of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
A Single Arm Pilot Study of
Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome.
Zou K. Advances in the
study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system.
Gut Microbiota - Regulated
Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration — Ru Feng — Frontiers in Pharmacology
To find out if their hypothesis held true, the researchers administered either 100 mg /
kg of berberine or saline (control) to diabetic rats.
24) Sun, Yiyi, et al. «A systematic review of the anticancer
properties of berberine, a natural product from Chinese herbs.»
In a randomized investigation of the
impact of berberine in patients with weakened hearts and congestive heart failure (CHF), there was an increase in heart strength and a decrease in measures of CHF in those assigned to the group taking berberine.
[5] Jiang, X., et al. «Effects
of berberine gelatin on recurrent Aphthous Stomatitis: A randomized, placebo - controlled, double - blind trial in a Chinese cohort.»
What would be the daily recommended
dose of Berberine to obtain results as the ones mentioned in this article?
A 2008 study performed on 36 patients found that 1000 - 1500 mg
of berberine extract per day lowered blood insulin by 44 % and insulin resistance by 28 %, all within a few days.
Supplementation of berberine is shown to stop diarrhea which contributes to the spread of bacteria, directly inhibits the growth of E. coli and Pseudomonas (P.) aeruginosa and act as an anti-adhesive agent along the urinary tract (16).
However the
powers of berberine are still extremely interesting regarding the insulin and also the testosterone connection which Alexander pointed above.
The different
mechanisms of berberine are complicated, but one of the main functions is to activate the AMPK enzyme (6).
In a recent 2014 study, researchers compared the
effectiveness of berberine and metformin in PCOS women scheduled for IVF treatment.
Repeated use
of berberine down - regulates several important liver enzymes (P450 cytochromes) that the body uses to eliminate drugs especially CYP2D6, CYP2C9, and CYP3A4.
The
addition of Berberine relaxes the arteries, increases blood flow, lowers blood pressure and protects against atherosclerosis.
The therapeutic
dosage of berberine to improve insulin and other proven health benefits based on published studies is 500 mg, 3 times each day (similar to that of metformin dosing).
The second study was for 3 months, during which 37 individuals with metabolic syndrome were given 300
mg of berberine 3 times per day.
The potent
effect of berberine on diabetes was highlighted even further in a meta - analysis of 14 trials that involved a total of 1,068 participants.
It also contains bayberry bark and grapefruit seed, which complement the
actions of berberine to support healthy microbial activity, stimulate circulation, and promote mucous membrane health.
In a well - known study called «
efficacy of berberine in patients with type 2 diabetes mellitus», scientists gathered 36 patients newly diagnosed with type 2 diabetes.
A big
benefit of berberine is that it specifically targets fat cells to reverse fat storage, especially in the central part of the body.
Li Y1, Ma H, Zhang Y, Kuang H, Ng EH, Hou L, Wu X. Effect
of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial.
A clinical study on the short - term effect
of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.
Meta - analysis of the effect and safety
of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension.
Raising SCFA levels in the intestine contributes to the beneficial effects
of berberine to lower insulin resistance, obesity, diabetes, and other metabolic disorders.
The effects
of berberine have been compared to metformin in women with PCOS.
Patients were randomly assigned to take either 500 mg
of berberine two or three times a day for 3 months, or the common diabetes drug metformin.
They fed 100 mg
of berberine or a placebo to rats for several weeks and noted that «berberine treatment not only augments GLP2 secretion and improves diabetes, but is also effective in repairing the damaged intestinal mucosa, restoring intestinal permeability and improving endotoxemia».
We use GI Regulator, which has therapeutic dosages
of berberine, zinc and grapefruit seed extract within it.
In a 12 week long study of obese individuals that were given 500 mg
of berberine 3 times a day, they lost an average of 5 pounds, and 3.6 % of their body fat (17).
In a 2012 study published in the European Journal of Endocrinology, researchers evaluated the effects
of berberine in comparison to metformin in women with PCOS.