Sentences with phrase «of biologic therapies»

The chronic leukemias have very effective treatments in the form of biologic therapies (such as Gleevec for CML), which are designed to stimulate the body's immune system to target cancer cells.

The research team evaluated the combination of the biologic therapy brentuximab vedotin (Adcetris), a monoclonal antibody - drug conjugate, with the chemotherapy drug gemcitabine (Gemzar) in 42 pediatric and young - adult patients with Hodgkin lymphoma, the most common cancer in young people ages 15 to 29.

Interferon is a type of biologic therapy.

Clinical trials are studying different combinations of biologic therapy, chemotherapy, steroid therapy, and drugs.

The antibody targets a peptide on cancer cells, and is a form of biologic therapy, an increasingly appealing alternative to chemotherapy.

Not exact matches

Samsung's Bioepis arm has been on a quest to create biosimilars — or copycats of biologic drugs that are usually priced at deep discounts — of some of the world's top therapies.

The Chiesi fund will consider a wide range of opportunities, from traditional small molecules and biologics, to gene therapies and cell therapies, to diagnostic and disease management technologies.

The med significantly upped the proportion of patients to achieve a 20 response at week 16 when compared with placebo in patients who hadn't yet received a biologic therapy.

The ability to identify those patients unlikely to respond to first - line biologic anti-TNF therapies prior to their treatment would allow these patients to be prescribed alternative therapies, providing faster relief of symptoms and reducing the risk of future complications.

Faced with an increasing choice of different biologic therapies, rheumatologists have a critical need for better tools to inform their management of RA.

Next, the scientists identified which of these patient populations had joints that were getting better and what biologic therapies they were taking.

The study found no clear change in blood eosinophils with dupilumab therapy; however, other biomarkers decreased, including fractional exhaled nitric oxide, thymus and activation regulated chemokine, immunoglobulin E and eotaxin - 3, confirming the biologic activity of dupilumab.

Better control of inflammation with biologic therapy might reduce not only the rate of heart attacks, but potentially also affect the size of myocardial infarctions.»

Whilst established to examine possible safety issues with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior clinical lecturer and honorary consultant rheumatologist; Arthritis Research UK Epidemiology Unit, The University of Manchester; and an investigator in the study.

Stepping up to biologic therapy when methotrexate monotherapy fails offers minimal incremental benefit over using a combination of drugs known as triple therapy, yet incurs large costs for treating rheumatoid arthritis (RA).

Results of a comprehensive cost - effectiveness analysis suggest that patients who have RA and no contraindications to triple therapy should use it prior to a biologic as the next regimen.

The authors cite literature showing this is a strategy that many patients would prefer anyway, since it could reduce their out - of - pocket costs, and would not expose them to the risk of serious side - effects associated with biologic therapy.

These biologic therapies use an antibody class called immunoglobulin - G (IgG) to bind to and prevent the activity of specific proteins or growth factors.

After discontinuation of triple therapy according to either definition, 59.3 percent tended to switch to or add another DMARD, while 41.2 percent added a biologic drug.

Data on 10,156 RA patients from 1998 to 2012 were analyzed to determine what percentage of patients discontinued triple therapy, and how long they took the combination of drugs before discontinuing or adding a biologic drug.

Michigan Medicine and MedImmune, the global biologics research and development arm of AstraZeneca (NYSE: AZN), have entered into a three - year research alliance to identify potential new therapies for the prevention and treatment of diabetes, obesity and related metabolic disorders.

His track record includes biologics and gene therapies, which were new technologies to both U.S. and European regulators at the time of their development.

With continued growth in development and approval of biologic drugs and cell therapies comes a need for more robust and predictive cell - based assays.

select the most effective therapy based on the unique biologic characteristics of the patient and the molecular properties of a tumor or other disease

Paris, France, April 3, 2018, 5.35 pm CET — GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA - PME eligible), a biopharma company focused on discovering and developing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced topline results from the REVERSE Phase III clinical trial evaluating the safety and efficacy of a single intravitreal injection of GS010 (rAAV2 / 2 - ND 4) in 37 subjects whose visual loss due to 11778 - ND4 Leber Hereditary Optic Neuropathy (LHON) commenced between 6 and 12 months prior to study treatment.

The KININ meeting occurs every three years, assembling scientists and clinicians involved in the field of bradykinin (kinins) and its related proteins (enzymes, cofactors, substrates, receptors, proteolytic systems, disease states, and developing therapies) for presentation of the latest ideas, research, drug development and therapeutics in these biologic systems.

Focused on meeting this urgent unmet medical need, ALS TDI executes a robust target discovery program, while simultaneously operating the world's largest efforts to preclinically validate potential therapeutics; including a pipeline of dozens of small molecules, protein biologics, gene therapies and cell - based constructs.

Sean has more than 20 years of regulatory experience across a range of categories including biologics, gene therapy, chemistry, manufacturing and control (CMC) and medical device

LHV is co-founder, shareholder, member of the Scientific Advisory Board, and consultant of GenSight Biologics, an ophthalmology gene therapy company.

She is proud to be one of the few rheumatologists who does not routinely start her patients on biologic and DMARD therapies.

A report published in Dermatologic Therapy, [15] shows that «the use of topical antioxidants is gaining favor among dermatologists because of their broad biologic activity.»

Treatment options for these include surgery, chemotherapy and other biologics (specific types of drugs), hormonal therapy and radiation.

The cohort included 9 patients with symptomatic Crohn's disease (CD) and 6 with ulcerative colitis (UC), half of whom were on biologic therapy, with an average disease duration of 19 years (1).

The biologic treatments of anabolic stimulation of the tissues with injections, exercise, physical therapy and activity coaching are becoming more effective, more targeted and more widespread.

Due to its advantages of both safety and affordability, it's non-invasiveness, and the fact that it's drug - free, Stem Cell Therapy by MediVet Biologics is the most logical cell therapy choice for the treatment of the folTherapy by MediVet Biologics is the most logical cell therapy choice for the treatment of the foltherapy choice for the treatment of the following:

Canine TCC is almost identical to human invasive TCC (invasive urothelial carcinoma) in histopathologic characteristics, molecular features studied to date, biologic behavior (sites and frequency of metastasis), and response to medical therapy.

Thanks to use of biologic line products Comfort Zone our therapists promote the mountain well - being with specific therapies signed Nira SPA.

Preparation and global prosecution of patent applications directed to diagnostic and therapeutic products including antibodies, gene therapies, vaccines, stem cells, pharmaceutical formulations, nanotechnology, nucleic acid molecules, biologics, medical devices, mouse platforms for antibody development, and methods of treating diseases.