Sentences with phrase «of biological therapies»
A fact sheet that provides an overview of how the immune system functions and describes the actions of biological therapies, such as monoclonal antibodies, cytokines, therapeutic vaccines, the bacterium bacillus Calmet - Guérin, cancer - killing viruses, gene therapy, and adoptive T - cell transfer.
https://www.cancer.gov/
Maini's work as a rheumatologist has made dramatic improvement in the quality of life of sufferers of rheumatoid arthritis through the development of the biological therapy, anti-TNF.
Not exact matches
And a third, different kind of gene therapy from Spark Therapeutics — to treat a rare inherited form of blindness — is likely to be approved by the end of 2017, too, making this year a landmark for treatments that manipulate the body's own biological mechanisms in novel new ways to fight deadly diseases.
Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.
Unlike many clinical trials that emphasize relief of symptoms as their primary objective, the ezogabine study's goal is to gauge how well the therapy addresses some of the biological underpinnings of depression — in this case, whether the drug lessens the hyperactivity of the reward circuit that includes VTA neurons.
Steve: So that if the underlying biological situation seems to be a dearth of GABA receptors, perhaps a therapy that increases, that amps up the levels of the GABA receptors might be efficacious?
The outcomes of this work open new avenues of research with the goal of elucidating the biological mechanisms underlying asthma in relationship with environmental exposures and to promote the development of new therapies.
«Our results suggest that we've been looking at these cancer drugs the wrong way — as tumour - targeting drugs — instead of what we now feel is their most important biological role: as immune stimulating therapy.»
The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies than currently available.
«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.
Ultimately the aim is to better understand the psychological and biological effects of treatment — in order to develop more effective therapies.
After decades of hopes raised and dashed, pediatricians, immunologists, and others are cautiously hopeful that new biological insights and a push for treatment from parents - to - be could turn the tide for prenatal stem cell therapy.
This matters for the optimisation of ion - beam cancer therapy, which requires a thorough understanding of the relation between the physical characteristics of the incoming ion beam and its effects on biological tissues.
«We are joining everyone who spends their days thinking about preventing cancer, about better understanding its biological basis, about bringing early detection and education to all communities, about developing new treatments and therapies and about caring for patients and their families through some of the hardest days anyone faces.»
The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»
«The paper by Dunsmoor and colleagues highlights that we are still learning important information about how to maintain the benefits of cognitive behavioral therapy,» said Dr. John Krystal, Editor of Biological Psychiatry.
At a meeting last week of the International Society for Biological Therapy of Cancer in San Diego, California, Oncolytics Biotech of Calgary in Alberta, Canada, reported positive results from two trials of its drug Reolysin, which contains reovirus.
Learning more about the genes and biological processes may guide the development of weight - loss therapies, and help doctors tailor the health advice they give to patients.
«Science is pleased to partner with Sartorius to recognize leading work in the rapidly developing fields of regenerative medicine and cell therapy», said Science Editor - in - Chief Jeremy Berg, «These fields and the inaugural awardee review how decades of work on basic biological mechanisms might be harnessed to yield new therapies.»
The new Salk tool, called CasRx, opens up the vast potential of RNA and proteins to genetic engineering, giving researchers a powerful way to develop new gene therapies as well as investigate fundamental biological functions.
Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy of Parkinsonism (DATATOP) study, which is the largest cohort assembled to date with longitudinal collection of biological fluids and clinical data from PD patients.
«Learning more about the biological impact of the HOXA5 protein, which is absent so frequently in breast cancers, may eventually help scientists develop new therapies to treat this disease,» says Sukumar.
«This camera has the potential to greatly enhance our understanding of very fast biological interactions and chemical processes that will allow us to build better models of complex, dynamical systems such as cellular respiration, or to help doctors better deliver and monitor light - based therapies,» says Richard Conroy, Ph.D., program director for Optical Imaging at NIBIB.
For people, substitution therapies, which include slow acting opioids (methadone), opioids that produce a partial biological response (buprenorphine) or antagonists that block the opioid receptor (naloxone), are the only available treatments for opioid addiction are often leading to high rates of relapse.
Their findings could help to improve breast cancer prevention by targeting these specific biological mechanisms with cancer therapies in at risk patients and potentially lead the way for a new strategy for the use of preventative treatments.
The next step will be to optimize the approach and to extend it to protein - protein interactions, protein - gene interactions, disease - protein interactions, disease - drug interactions all with a view to improving diagnostics and tailoring therapy for the individual patient based on the outcomes of their personal biological network analysis.
CRISPR - Cas9 has supercharged biological research in a mere six years, speeding up exploration of the causes of disease and sparking many potential new therapies.
Next Wave asked: If research on gene vectors can be used not only to further gene therapy but also — potentially — to aid in the development of biological weapons, should scientists be concerned about the potential applications of their research in genetics (as Joseph Rotblat suggested in a 19 Nov 1999 editorial in Science magazine?)
Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.
In their «Editorial comment to the «NIA - AA Research Framework: Towards a Biological Definition of Alzheimer's Disease,»» Nina Silverberg, Ph.D., Cerise Elliott, Ph.D., Laurie Ryan, Ph.D., Eliezer Masliah, M.D., and Richard Hodes, M.D., of NIA point out that the Framework — in addition to improving early detection and the development of new therapies — could potentially «allow more precise estimates of how many people are at risk [for or living with] Alzheimer's disease, how best to monitor response to therapies, and how to distinguish the effects of Alzheimer's disease from other similar pathologies.»
An improved understanding of the biological background of musical aptitude can contribute new insights into, for instance, genes that affect normal brain functions, the interactions between genes and the environment and the significance of music as a form of therapy.
«This research shows that it is possible to promote psychological well - being in middle childhood through an integrated school - based intervention programme informed by concepts of positive psychology and cognitive behavioural therapy,» said first author Dr Michael Pluess from QMUL's School of Biological and Chemical Sciences, who led the research while previously based at University of East London.
We will next consider the methods available to analyze biological networks, demonstrate the application of these principles to selected problems in biology and medicine, and discuss the implications of biological network theory as a construct for characterizing human disease and defining novel therapies.
«The identification of NMD's role in longevity opens the door to the development of new therapies to prolong lifespan,» said Kevin Strange, MDI Biological Laboratory president.
Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.
The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.
As a result, they are of great interest for fields such as biological imaging, medical diagnostics, drug delivery, and gene therapy.
BAR HARBOR, MAINE — Recent research by Sandra Rieger, Ph.D., of the MDI Biological Laboratory identifying the underlying mechanisms of peripheral neuropathy, or nerve damage, has raised the prospect that drug therapies can be developed for the treatment of this condition, which causes pain, numbness and / or tingling in the hands and feet.
«In particular, his approach can be thought of as a very advanced biological therapy for the treatment of breast cancer; one that uses viruses, which are better recognized to cause disease, to treat human breast cancers.»
Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.
LA JOLLA — Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies.
The ultimate goal is to increase the number of new diagnostics and therapies for patients while reducing the time and cost of developing them, by jointly identifying and validating promising biological targets for several diseases, including type 2 diabetes.
Researchers continue to decode the mysteries of hematologic malignancies, and the most successful therapies target the genetic or biological abnormality that is spurring the growth of cancer cells.
«We are focused on the discovery and development of new regenerative medicine therapies,» said Kevin Strange, Ph.D., MDI Biological Laboratory president.
The MDI Biological Laboratory has a partnership agreement with ARMI to promote research and education on regeneration and the development of new therapies to improve human health.
In March 2006, the Burnham Biomedical Research Institute (subsequently renamed the Sanford Burnham Prebys Medical Discovery Institute), the Salk Institute for Biological Studies, The Scripps Research Institute and the UC San Diego formed San Diego Consortium for Regenerative Medicine and adopted the mission of expanding collaborative stem cell research and translating discoveries into clinical therapies and cures.
LA JOLLA, CA — Using a gene therapy delivery system developed in the laboratory of Inder Verma at the Salk Institute for Biological Studies, an international team of researchers successfully treated two...
By emulating biological principles of self assembly, organization and regulation, we are developing disruptive technology solutions for healthcare, energy, architecture, robotics, and manufacturing, which are translated into commercial products and therapies through formation of new startups and corporate alliances.
Simona thinks that this cell biological approach could help make sense of the heterogeneity of gliomas and improve our understanding of invasion overall: «These are key questions — we need to know how invasion is driven as it could have profound implications for therapy».
Given the tailored inhibition of selected genes and the added precision brought by targeted delivery systems, RNAi - based therapies are thought to carry lower risk of failure than traditional approaches as the biological effects are more predictable.