Sentences with phrase «of blood vessels in tumors»

A new study led by scientists at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) suggests that dopamine — an inexpensive drug currently used to treat heart, vascular and kidney disorders — can be safely used in cancer treatment to curb the growth of blood vessels in tumors.

However, when these myeloid cells migrate to tumor sites, they can differentiate to tumor associated macrophages (TAMs), which can in turn stimulate the formation of blood vessels in tumors and promote enhanced tumor cell invasion and motility.

Not exact matches

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

In the presence of these drugs tumors grow faster and develop more extensive networks of the blood vessels they rely on to feed their expansion — a process called angiogenesis, says Jonathan Moss, an anesthesiologist at the University of Chicago (U. of C.) Medical Center.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

We found that the inflammation unfortunately gets hijacked by tumor cells that are able to grow faster and penetrate deeper because the blood vessels in the brain are more permeable than in any other part of the body.

That's because hospitals are equipped with powerful new scanning machines primarily used to identify tumors, ballooning blood vessels, bone fractures, and a wide range of disorders in people.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

With the approval of the local ethics committee, a 16 - year - old boy with a rare type of liver cancer called fibrolamellar hepatocellular carcinoma was given infusions of 3BP into the blood vessels supplying the tumor, formulated in a proprietary and patented fashion.

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

A study published in the journal PLOS ONE reports that the synthetic molecule JK - 31 blocks the signalling of a «growth factor» chemical that promotes the creation of networks of blood vessels to feed tumors.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

Breast tumors have a denser network of blood vessels than those found in a healthy breast.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia AgostiniIn this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostiniin the tumor,» says Patrizia Agostinis.

Less suppression of the immune response and less blood vessel formation in the tumor leads to less tumor growth.

Indeed, tumors contain a lot of specific macrophages that play a decisive role in the formation of blood vessels.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

«We saw the formation of new blood vessels in tumors reduced by 70 percent,» she says.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreaIn earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreain direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

Trebananib (formally known as AMG 386; Amgen) is a first - in - class peptide - Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

One explanation for that, says Iacobuzio - Donahue, is that «Distant metastases have to travel long distances along the «highways» of the blood vessels, land in a good spot and colonize, while local metastases just pinch off the primary tumor and go a short distance on «familiar side roads,» so they are usually more similar to the primary tumor.»

In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.

To demonstrate the potential for treating lung disease, the researchers used the nanoparticles to block two genes that have been implicated in lung cancer — VEGF receptor 1 and Dll4, which promote the growth of blood vessels that feed tumors.

In addition, Zeitels notes, the treatment's mechanism of eradicating the blood vessels supplying a tumor — highly effective for conventional vocal - cord cancer — is even more useful for treating tumors caused by HPV infection, which are characterized by an excessive overgrowth of blood vessels.

Researchers at the University of Mississippi recently found that ethanol — the alcohol in alcoholic drinks — speeds tumor growth by stimulating blood vessel formation.

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

This helped to confirm that in addition to relying on leaky blood vessels for nanoparticles to gain access to the tumor, a major inducible vascular transit pathway is available in the form of the vesicle transport system.

This process requires a fundamental change in the character of cells within the primary tumor, insofar as members of a localized cell mass must be converted into actively migrating cells that invade into the surrounding tissue and blood vessels, and finally settle in distant tissues.

It's thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channeIn an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channein the adjacent channel.

Once Pasqualini and Arap know which blood vessels a peptide latches on to, they can attach a drug to that peptide; in the case of cancer, the drug might destroy the vessels that feed a tumor.

In the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiIn the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiin atherosclerosis.

«This peptide acts as a «zip code» in that it enables the binding of the nanoparticles only to blood vessels within the tumor and not normal blood vessels,» says Alnawaz Rehemtulla, a radiologist and environmental health scientist who co-authored the study.

Therapies that prevent tumor blood vessel growth are often used in clinics to fight cancer — but they are only effective in a particular subset of patients.

Frangioni is also CEO of Curadel, a company he started in 2014 with the purpose of developing NIR contrast agents and imaging systems to help surgeons identify glands, blood vessels, nerves, lymph nodes, and tumors during operations.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

«If we could prevent development of the new blood vessels in the cancer tissue driven by these signals, tumor growth and metastasis can be slowed down or prevented.»

Earlier studies by Basu and others have shown that dopamine blocks the growth of new blood vessels in tumors by inhibiting the action of vascular endothelial growth factor - A (VEGF - A).

Using a mathematical modeling approach, scientists have found that certain parameters of tumor growth in mice can predict the effectiveness of drugs that block formation of tumor - nourishing blood vessels.

The researchers had previously built a mathematical model that simulates the activity of a blood - vessel - growth - promoting protein called VEGF in a mouse tumor.

In this study, NIH scientists used mouse models to show that anthrax toxin proteins work by specifically targeting the cells that line the inner walls of the blood vessels feeding the tumor.

Knowing that insulin can stimulate the growth of blood vessels, «our expectation was that knocking out insulin signaling in these cells might slow the growth of blood vessels and reduce tumor formation in these mice,» Rask - Madsen says.

They discovered that PSMA is strongly expressed in the new blood vessels of all solid tumors.

He previously revealed the existence of spontaneous immune responses in ovarian tumors as well as described how regulatory T cells and tumor blood vessels affect these responses.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

In both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular LyftIn both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyftin three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyfts.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

Instead, cutting levels of VEGF in a tumor actually props up existing blood vessels, making them stronger and more normal, and in some cases the tumors larger.