Neuroscientists have documented that the earliest days, weeks and months of life are a period of unparalleled growth when trillions
of brain cell connections are made.
The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to «synaptic pruning» — the healthy reduction during adolescence
of brain cell connections that are no longer needed.
The research effort he directs focuses on entirely new compounds that might slow the loss
of brain cell connections, which may play a role in schizophrenia biology.
Not exact matches
That's because the
brain is involved, and — as an astoundingly complex network
of 100 billion
cells and their 100 trillion
connections — the organ does not easily loose its secrets.
Maybe one day someone may construct an exact copy
of the millions
of cells in the
brain with billions
of connections with microchips and whatever, then set electronic currents flowing.
A newborn baby has over 2 billion
brain cells, but
connections between these
brain cells have not yet been developed and will constitute the majority
of the 75 percent
of the
brain left to grow after birth (Sunderland, 2006).
Although infants have most
of the
brain cells they need for learning when they are born, the
cells still need to form
connections.
After a baby is born, there continues to be a building
of important
brain cell connections and the introduction
of stimulants like sound, color, touch and toys greatly enhances that development.
The problem is that they have a lack
of Synapses (
brain cell connections).
«Exposure to different sounds and scenes is essentially what helps establish
connections from one set
of neurons — the nerve
cells of the
brain — to another.
The authors
of the study referenced in the article found there was no causal
connection between light and
cell division in the
brain of mice if they had artificial light shined at them at one - hour intervals.
Disruptions to the ability
of developing
brain cells to form branching
connections with other
cells, using a specific microRNA — miR - 9, was associated with an increase in the strength
of fear - related memories in adulthood.
Their
brains differed in the activity
of over a hundred genes that provide
cells with energy, influence chemical communications in the
brain and strengthen the
connection between nerve
cells.
About five years ago, a team
of Stanford University scientists set out to determine how the developing
brain establishes its final set
of synapses,
connections through which
cells of the nervous system communicate with one another and with nonneural
cells.
Scientists have discovered why a single mutated protein can lead to serious mental retardation in men with a common genetic disorder called fragile - X syndrome: The healthy protein is essential for establishing during childhood the adult pattern
of connections between nerve
cells in the
brain.
Unfortunately, many
of these
connections will be to wrong areas, parts
of the
brain where the ganglion
cell doesn't need to go.
She found that
cells born early reach for many areas
of the
brain and make lots
of connections.
In a human
brain, 85 billion nerve
cells communicate via trillions
of connections using complex patterns
of electrical jolts and more than 100 different chemicals.
Last month, researchers led by Beth Stevens
of Boston Children's Hospital reported that a process in which microglia prune excess synapses in the
brain during early life can turn on inappropriately later on, possibly triggering Alzheimer's or other disorders marked by damage to
connections between
brain cells.
First she deprived juveniles
of vision in one eye so that the corresponding
brain cells failed to make
connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern
of fine lines to find a floating platform.
Steve: And that the thickness is networks
of nerve
cells joining together and then the thinness is discarding
of some
of those
connections when the
brain figures out they don't need them.
«It was like neighborhoods
of nerve
cells in the eye were placing phone calls to the
brain to check
connections,» Shatz recalls.
The researchers used a technique called laser scanning photostimulation to map the
connections between individual subplate neuron
cells in the
brains of the mouse pups.
GLP - 1 receptors are also found in the
brain, and prior research has shown that activating them can boost the function
of dopamine
connections, act as an anti-inflammatory, improve energy production, and switch on
cell survival signals.
Modha's new chips contain silicon components that crudely mimic the physical layout
of, and
connections between, microscopic carbon - based
brain cells.
USE it or lose it: a class
of immune
cell demolishes idle circuits and
connections in the
brain, even a healthy one.
By examining the
brains of bees trained to different tasks, the researchers found that the number
of connections between nerve
cells may hold the answer to questions about individual cognitive differences.
But in the case
of synapses, which are the
connections between
brain cells, too many or too few can both disrupt
brain function.
«Severe stress affects the size
of the structures in the
brain, causes
cell death, and affects the number
of connections between
brain cells,» observes Kalin.
And that could influence the progression
of Alzheimer's, he adds, by influencing how
brain cells react to the loss
of connections between neurons that accompanies the disease.
Kenyon
cells make up only about 4 %
of the entire fly
brain and are extremely sensitive to inputs triggered by odors, in which only two
connections between neurons, called synapses, separate them from the receptor
cells at the «front end»
of the olfactory system.
Variants
of a protein that helps snip
connections between nerve
cells in the
brain may contribute to the disorder, scientists report January 27 in Nature.
At a symposium at The American Society
of Human Genetics here last month, they reported zooming in on the genes expressed in a single
brain cell, as well as panning out to understand how genes foster
connections among far - flung
brain regions.
A renowned neuroscientist sees ideas
of selection as describing the honing
of connections among
brain cells.
Instead, it's the largest map to date
of the
connections between
brain cells — in this case, about 200 from a mouse's visual cortex.
She hopes to pinpoint which genes are expressed in each
cell type when
brain cells make long distance
connections, and to make similar maps in other primates to chart what changed as
brains rewired over the course
of evolution.
His work suggests that deep -
brain stimulation — whether electrical or optical — may be most effective when it targets not the neurons themselves but the
connections between
cells, thereby affecting the flow
of activity between
brain regions.
The report highlights the need for cheaper, faster technologies that can trace
connections between individual
brain cells and record large networks
of cells acting in synchrony.
And the images he's creating are part
of an ambitious attempt to understand how the
connections between those
brain cells give rise to the mind.
«Synapse discovery could lead to new treatments for Alzheimer's disease: Scientists have discovered how
connections between
brain cells are destroyed in the early stages
of Alzheimer's disease.»
Mapping the structure
of the human
brain is a daunting task: Billions
of cells make vast numbers
of connections, and tracing these tangled fibers is so labor - intensive that analyzing just one square millimeter
of tissue takes years.
A new in vitro model Scientists developed a new research tool for this study that enabled them to monitor the spread
of Tau aggregates whilst changing the synaptic
connections between
brain cells.
Researchers from Hiroki Taniguchi's lab at the Max Planck Florida Institute for Neuroscience (MPFI) published a study in eNeuro in May 2017 showing for the first time that a unique type
of inhibitory interneuron called chandelier
cells — which are implicated in several diseases affecting the
brain such as schizophrenia and epilepsy — seem to develop their
connections differently than other types
of neurons.
While most researchers use Brainbow to visualize
connections between nerve
cells in the
brain, Alain Chédotal
of the Institut de la Vision in
A team
of researchers led by UNSW Australia scientists has discovered how
connections between
brain cells are destroyed in the early stages
of Alzheimer's disease — work that opens up a new avenue for research on possible treatments for the degenerative
brain condition.
Almost all theories
of memory propose that memory storage depends on synapses, the tiny
connections between
brain cells.
There are more than a trillion
cells called neurons that form a labyrinth
of connections in our
brains.
«This study suggests that amyloid deposition in the gray matter affects the associated white matter
connections, which are essential for conducting messages across the billions
of nerve
cells in the
brain, allowing for all aspects
of mental function.»
The team, led by Stephen Liberles, Harvard Medical School associate professor
of cell biology, has effectively deconstructed the vagus nerve, a key
connection between body and
brain that is important because it controls not only breathing but also heart rate, feeding behavior and responses to illness.
The substance, which naturally supports
brain cells throughout life, also amplified the numbers
of connections, or synapses, between neurons.