Sentences with phrase «of brain cell death»

This unique pattern of brain cell death causes different symptoms in each disease.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

After 10 days of age, the manipulations reduced the distance flies could climb up tubes and the alterations caused older flies to have signs of neurodegeneration, including higher than normal levels of brain cell death and degradation.

«The bottom line question,» says Christopher Austin, a neurogeneticist at Merck Research Laboratories in West Point, Pennsylvania, is whether this kind of gene therapy can stem the rate of brain cell death.

Not exact matches

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

Which seems to suggest that souls are just wishful thinking and that nothing of our self - awareness survives the cell - death of our brains.

It's sometimes said that nutritional yeast contains compounds similar to monosodium glutamate (MSG), an excitotoxin that overexcites your cells to the point of damage or death, causing brain damage.

The scientists describe that this protein triggers the death of brain stem cells.

Bingwei Lu, a neuroscientist at Stanford University in California, has shown that a microRNA sequence which suppresses certain genes is linked to the death of brain cells in fruit flies.

The results could provide insights into the Zika virus» recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.

This type of inflammation between 18 and 32 weeks of gestation in humans has been linked to preterm birth as well as an imbalance of immune cells in the brain of the offspring and even death of nerve cells in the brains of those children.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

The tremors and other movement impairments of Parkinson's are triggered by the death of dopamine - producing cells in the brain, so the investigators used flies that had been genetically engineered to have their dopamine cells die off as they age.

«Damaging consequences of Zika virus infection in human minibrains: Zika virus reduces growth, induces cell death, malformations in human neurospheres, brain organoids.»

Neurodegenerative diseases are caused by the death of neurons and other cells in the brain, with different diseases affecting different regions of the brain.

«After circulatory arrest, spreading depolarization marks the loss of stored electrochemical energy in brain cells and the onset of toxic processes that eventually lead to death.

The disease is progressive and degenerative, wherein the death of brain cells causes an array of motor and non-motor symptoms, most recognizably tremor, rigidity, slow movement and unstable posture.

These proteins are thought to be a hallmark of Alzheimer's disease, and their formation may trigger other changes that lead to the death of brain cells.

«Shutting off vital tumour growth processes can lead to the death of human brain tumour - initiating cells.

An increased amount of miRNA in brain cells was correlated with a younger age at disease onset and an earlier age at death of the patients.

They also tested other chemicals known to prevent the other two forms of cellular suicide, but only CGP3466B protected mouse nerve cells in the brain from death by cocaine.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

«Severe stress affects the size of the structures in the brain, causes cell death, and affects the number of connections between brain cells,» observes Kalin.

Accumulation of toxic prions triggers the death of nerve cells and literally leaves holes in the brain, causing a spongiform (or sponge - like) appearance.

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

All of the diseases, which cause the death of brain cells involved in controlling body movements, have recently been traced to specific genes.

Dor's own group reports this week that its technique for tracing the origin of circulating DNA detected the expected type of cell death in people with pancreatic cancer, type 1 diabetes, multiple sclerosis, and brain injuries.

«Our studies show that broken - down components of the nuclear transport machinery lead to traffic jams within brain neurons of essential information and eventually brain cell death,» says Grima.

This situation can create a cycle of toxic tau, inflammation and cell death throughout the brain over time.

The researchers studied the brains of people who died from HD and those who died of other, non-neurological diseases and identified a very specific genetic signal that strongly correlates disease severity and extent of neuronal, or brain cell death.

According to the researchers these findings may represent a more effective way to tell whether or not HD treatments may be slowing down the pace of the death of brain cells.

The nerve cell death in Alzheimer s patients is linked to the build - up of plaques in their brains, which consist mostly of an insoluble protein called β - amyloid.

When this happens, molecular nutrients can no longer move to where they are needed and the oligomers produce toxic effects leading to the eventual death of the brain cells.

The Cambodian strain also led to the death of a few brain cells, but perhaps not enough to cause microcephaly.

Other studies have shown that the virus is capable of moving into brain cells, modifying the regulation of the cell cycle, and inducing their death.

PSD - 95 inhibitors interfere with the process that triggers cell death when the brain is deprived of oxygen.

One of those treatments might someday be based on a synthetic protein fragment that Robert P. Hammer of Louisiana State University has developed to disrupt formation of the plaques believed to provoke massive brain cell death in Alzheimer's patients.

The researchers injured the mice retinas with a toxin that causes cell death in retinal ganglion cells and interneurons, another type of retinal cell whose job it is to transmit signals from photoreceptors to the brain.

In the first part of their experiment they simulated the type of cell death that occurs in stroke by adding a chemical to brain cells in a dish.

The invocation of cell death in this disorder would explain the clinical feature, the small heads caused by loss of nerve cells in the brain, the team found.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Through a series of sophisticated experiments, researchers reporting in The American Journal of Pathology suggest that matrix metalloproteinase - 3 (MMP - 3) plays a pivotal role in disruption of the brain / spinal cord barrier (BSCB), cell death, and functional deficits after SCI.

These results collectively suggest that neural stem cells need MSI1 to generate enough neurons for normal brain size, but the presence of MSI1 also increases the vulnerability of these cells to Zika infection, leading to the death of the population which ultimately results in microcephaly.

Animal studies have shown that lengthy or multiple experiences with anesthesia can lead to cell death and problems with the formation of connections among brain cells.

«The Vienna team of Dr. Javier Martinez, also a co-corresponding author on the study, could actually show that mutations in CLP1 affect tRNA biogenesis and that CLP1 mutant brain stem cells become more apoptotic (invoking cell death).

For instance, autonomous vehicles could eventually prevent tens of thousands of road deaths; optogenetics — using genetic engineering and light to manipulate brain cell activity — could help cure or manage debilitating neurological diseases; and materials like graphene could ensure more people than ever have access to cheap clean water.

It appears that Sur1 is involved in many of the most dangerous symptoms in these diseases, including cell swelling, cell death, and the breakdown of the barrier that normally protects the brain and inflammation.

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.