Sentences with phrase «of brain plaques»

The research focused on the biomarkers involved in the buildup of brain plaques in the caudate and hippocampus.

The overabundance of this protein leads to the formation of the brain plaques associated with Alzheimer's, the researchers believe.

«Structure of brain plaques in Huntington's disease described.»

After three months of feeding, the mice had reductions in Aβ plaques of up to 70 percent in the hippocampus and up to 40 percent in the cortex, whereas mice fed capsules that contained lettuce leaves without CTB - MBP added and mice that were not fed any capsules did not have any reduction in evidence of brain plaques.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Nature.

The «amyloid hypothesis» figures that a buildup of brain plaque is what leads to the cognitive decline that Alzheimer's patients experience.

Not exact matches

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

Mice that were given the drug showed reduced plaque buildup in the brain (a sign of Alzheimer's) and overall improved memory.

After the night with disrupted sleep, the researchers found people had higher levels of beta - amyloid proteins, the proteins that clump together and form the plaque found in Alzheimer's - afflicted brains, in the volunteers» spinal fluid.

A polyphenol called punicalagin is the anti-inflammatory agent in the fruit that vanquishes traces of plaque that accumulates in the brain cells.

It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression of multiple sclerosis, it has the ability to regenerate brain cells after a stroke, it has the ability to cross the blood - brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque from the brain (which studies haves linked to Alzheimer's), it may help to prevent certain types of cancer, and studies have shown that it inhibits cancer cell growth and metastases (meaning it keeps cancer from spreading).

Recent studies even show that plaque that builds up in the brain from unhealthy levels of cholesterol may be one of the most common reasons for Alzheimer's disease.

IN BRIEF Scientists have new evidence that suggests that THC inhibits the formation of amyloid plaques by blocking the enzyme in the brain that produces them.

An essential factor for preventing the buildup of this plaque will be ensuring the brain health throughout a person's life.

The actual process of vascular aging may predispose a person's brain to the increased amount of amyloid plaque buildup.

Studies at autopsy of people who had dementia have detected many of these so - called microvascular infarcts either by themselves or along with the plaques and tangles more typical of Alzheimer's in the brains of people with dementia.

Ongoing studies at Uppsala University in Sweden have shown that the chemical agent dubbed Pittsburgh Compound - B, or PIB, is a highly accurate marker of plaque buildup and that its abundance in the brain can predict whether patients with mild cognitive impairment will develop Alzheimer's — and when that decline will likely start.

LACK of sleep could accelerate the onset of Alzheimer's disease by encouraging toxic plaques to develop in the brain.

«Amyloid is one of many substances that builds up in plaques as a result of dying cells and atrophy in the brain,» he says.

«Brain cells from mice fed diets enriched with extra-virgin olive oil had higher levels of autophagy and reduced levels of amyloid plaques and phosphorylated tau,» Dr. Praticò said.

Rats with brain plaques develop further symptoms of Alzheimer's when given nicotine.

In addition, compared to mice on a regular diet, brain cells from animals in the olive oil group showed a dramatic increase in nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.

A composite biomarker score, created by combining two different ratios, predicted the presence or absence of A-beta plaques in the brain with about 90 percent accuracy in both groups of patients, the researchers found.

When Deter died five years later, an autopsy revealed that her brain was riddled with strange tangles and plaques of a fibrous material containing the remnants of dead brain cells.

In a study published online June 21 in the Annals of Clinical and Translational Neurology, the researchers show that the consumption of extra-virgin olive oil protects memory and learning ability and reduces the formation of amyloid - beta plaques and neurofibrillary tangles in the brain — classic markers of Alzheimer's disease.

But the brains of 10 - month - old Alzheimer's mice that had a severely reduced amount of an enzyme called BACE1 were essentially clear of new and old plaques.

A mouse engineered to have Alzheimer's disease and a gradual reduction in levels of the brain enzyme BACE1 stopped forming plaques (arrows in the first panel) as it aged.

If a clump of this tissue, called plaque, breaks free, it can travel into the brain and block a smaller blood vessel, causing a stroke.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Alzheimer's mice with normal BACE1 levels experienced a steady increase in plaques, clearly seen in samples of their brains.

Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers.

IRON overload may accelerate Alzheimer's disease, according to research that also reveals the role of beta - amyloid precursor protein (APP), which forms plaques in affected brains.

The HSP70 - boosted mice were much better than the others at finding their way around mazes, and post-mortems showed their brains to be free of the characteristic beta - amyloid plaques that clog the brains of people with Alzheimer's.

Subsequent analyses of the brains of these animals revealed that the drug reduced the plaques and tangles in the hippocampus, which is known to play a key role in learning the water maze, but not in the amygdala, which figures importantly in the dark chamber test.

Previously, researchers have focused on the role of protein deposits called amyloid plaques that lodge in the brain of Alzheimer's affected people.

Accumulations of plaques and tangles in the brains of patients with Alzheimer's disease were first observed more than a century ago.

The normal mice's brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.

But these plaques were also inside the brains of the normal mice in the joined pairs.

Until recently, the only way to look at human plaques was by analyzing the brains of people who died from the disease — a challenge one scientist compared to looking at a car wreck and trying to puzzle out the accident's cause.

This aberrant brain circuitry — the amyloid plaques and tau tangles — became the twin hallmarks of the disease that bears his name.

«Two individuals may harbor similar amounts of amyloid plaques and tau tangles in their brains, but one may be completely healthy while the other may have severe memory loss and dementia,» he says.

Recent research also has illuminated how the deadly cascade that leads to brain atrophy is set in motion: The buildup of amyloid plaques, working in tandem with certain gene mutations, sparks the formation of the renegade tau proteins.

The pathological form is a misfolded version of this molecule and known to initiate the formation of toxic plaques in the brain.

To treat humans, researchers must still find a way to deliver the protein fragments past the blood - brain barrier, which prevents circulating proteins from entering the brain, and to the site of the plaques.

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons.

Because the protein is normally found outside of blood vessels in the human brain, this suggests that plaques may form in a different way in chimps.

But Holtzman and other researchers previously demonstrated that plaques of amyloid - beta protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).

Rats with Alzheimer's brain plaques go on to develop additional signs of the disease when they are given nicotine

«Although previous research has shown that some head injury patients have these amyloid plaques shortly after the incident, these findings suggest these plaques are still present in the brains of patients over 10 years later.