Sentences with phrase «of cadherin»

W. E. Reintsch, A. Habring - Mueller, R. W. Wang, A. Schohl, F. Fagotto, beta - Catenin controls cell sorting at the notochord - somite boundary independently of cadherin - mediated adhesion.

By sequencing the DNA of resistant pink bollworm collected from the field in India — which grows the most Bt cotton of any country in the world — the team found that the insects produce remarkably diverse disrupted variants of cadherin.

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

For both cancer types, the research team used molecular tools to reduce the amount of cadherin - 22.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

The U of G researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin - 22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

Previous studies showed that cells which express the same type of cadherin interact with each other, but cells with different types of cadherins remain separate.

However, two types of cells in the olfactory epithelium (specialized tissue responsible for sense of smell), are mixed together and form a mosaic pattern despite expressing different types of cadherins.

The accumulation of different amounts of cadherins produced different levels of adhesiveness between cell junctions, resulting in a mosaic pattern.

(Right) Cells with different types of cadherins and nectins make a mosaic pattern through partial mingling.

Different roles of cadherins in the assembly and structural integrity of the desmosome complex.

Not exact matches

These findings suggest that the therapeutic protein was able to interact normally with its binding partners among the USH1 molecular complex (the proteins cadherin 23, protocadherin 15, myosin VIIA and harmonin), as required for the mechanoelectrical transduction apparatus of the hair bundle to function correctly.

Not only did they show that N - cadherin was necessary for creating the perfectly clear structure of the lens, they also observed that malformed lenses lacking N - cadherin began to attract immune cells to try to fix the damage.

The study builds on more than a decade of research from Cummings School of Veterinary Medicine and the University of Massachusetts Medical School that in 2010 initially found the neural cadherin (CDH2) gene on canine chromosome 7 appeared to coincide with an increased risk of OCD.

The rheumatoid arthritis drug, an anti-inflammatory, physically binds to cadherin - 11 (CDH - 11) on the surface of cells so that they can't bind together.

Nectins tend to bind heterophilically, meaning that they adhere more strongly to nectins of a different type, and have been shown to serve as recruiters for cadherin molecules.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

«What most of these cancers all have in common is cadherin - 11 and a poor prognosis, with no effective therapies,» Byers says.

All cells in tissues adhere to each other using molecules called cadherins which interact and connect cells of the same type together.

«Cadherin - 22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,» said lead author Prof. Jim Uniacke, Department of Molecular and Cellular Biology.

Studying breast and brain cancer cells in a hypoxia incubator, Uniacke and his team discovered that cadherin - 22 is involved in this process to enable the spread of cancer cells.

The Oncotarget study demonstrated that Brenner's antibody worked in animal models of tumors that made cadherin - 11.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

Dr. Islam's discovery was published [S. Islam, T. E. Carey, G. T. Wolf, M. J. Wheelock, and K. J. Johnson, «Expression of N - Cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell - cell adhesion,» J. Cell Biol.

He explains, «cadherins were mostly known for their role in the maintenance of normal tissue structure.

After completing his PhD, Dr. Islam decided to continue working on the molecular causes of cancer involving cadherins.

Center cells lost the expression of octamer - binding transcription factor 4 (OCT4) and epithelial cadherin (E-cadherin) faster than perimeter cells, which are critical to the development of heart tissue.

Binding of Bt toxin to cadherin is an essential step in the intoxication process.

Researchers at the Mechanobiology Institute have comprehensively described the network of proteins involved in cell - cell adhesions, or the cadherin interactome.

Up - regulated expression of zonula occludens protein - 1 in human melanoma associates with N - cadherin and contributes to invasion and adhesion.

Then they use polymerase chain reaction (PCR) to amplify a 300 - nucleotide Alu insertion into an intron of H - cadherin gene.

PI3K - Rac1 - JNK signaling mediates collagen I - induced cell scattering and up - regulation of n - cadherin expression in mouse mammary epithelial cells.

This gave a mixed population of cells with 20 % expressing CD34, a hematopoietic stem cell marker, with some co-expression of endothelial cell markers (CD31, Flk1, and VE - cadherin).

Connexins and Cadherin Crosstalk in the Pathogenesis of Prostate Cancer: DTIC Document.

Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N - cadherin in rat liver epithelial cells.

Collagen I — mediated up - regulation of N - cadherin requires cooperative signals from integrins and discoidin domain receptor 1.

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

N - Cadherin Dependent Collective Cell Invasion of Prostate Cancer Cells Is Regulated by the N - Terminus of α - Catenin.

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.

Amphimedon cadherins differ from those of Monosiga in having proteins with domain architectures diagnostic for the metazoan - specific classical cadherin and seven pass transmembrane cadherin subfamilies31, 35.

The diagnostic domains of two major cell — cell adhesion superfamilies, the cadherins and the immunoglobulins, are present in Monosiga within the extracellular region of putative transmembrane proteins31, 34 (Supplementary Note 8.8).

To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).

Dynamics between actin and the VE - cadherin / catenin complex: novel aspects of the ARP2 / 3 complex in regulation of endothelial junctions.