Sentences with phrase «of calbindin»

We then hypothesized that deltaFosB might be regulating the production of calbindin.»

«We found that seizures can increase the levels of deltaFosB in the hippocampus, which results in a decrease in the levels of calbindin, a regulator of memory processes.

DeltaFosB has a relatively long half - life, therefore even when seizures are infrequent, deltaFosB remains in the hippocampus for weeks acting like a brake, reducing the production of calbindin and other proteins, and disrupting the consequent brain activity involved in memory.

Not exact matches

The scientists found the same changes in deltaFosB and calbindin levels in the hippocampus of Alzheimer's disease patients and in the temporal lobe of epilepsy patients.

«In fact, we found that when the levels of deltaFosB increase, those of other proteins, such as calbindin, decrease.

And when researchers experimentally increased deltaFosB levels in normal mice, calbindin expression was suppressed and the animals» memory deteriorated, demonstrating that deltaFosB and calbindin are key regulators of memory.

Calbindin also has been known for a long time to be involved in Alzheimer's disease and epilepsy, but its mechanism of regulation was not known.

In layer 2, the density of cartridges arising from a transcriptionally - unique subset of chandelier cells containing calbindin was nearly 3-fold higher in the schizophrenia group.

In contrast, there was no difference in the density of chandelier cell cartridges lacking calbindin in layer 2 or in either type of cartridge across layers 3 - 6.

Aged mutant amyloid precursor protein mice with established disease showed a near complete restoration in levels of synaptic and neuronal proteins after exposure to young blood in parabiosis (synaptophysin P =.02; calbindin P =.02) or following intravenous plasma administration (synaptophysin P <.001; calbindin P =.14).