Sentences with phrase «of calcineurin»

This is a significant finding because the loss of control of calcineurin signalling seems to play a role in many diseases, including neurodegenerative disease, cardiac disease and cancers.

Dosage reduction may decrease toxicities; however, additional pharmaceutical drugs are often required to counteract the adverse effects of calcineurin inhibitor therapy.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Studies from a group at the University of Glasgow, which are published in the same issue of the journal, show the importance of calcineurin through different stages of the malaria life - cycle, implicating the protein as a potential target for blocking malaria transmission.

The research team at Harvard Chan School used cutting edge genetic and cell biological methods to provide definitive evidence of the essentiality and function of calcineurin in parasite invasion.

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

We also characterized the function of a family of endogenous inhibitors of calcineurin, originally termed MCIP but subsequently renamed as RCAN proteins.