Sentences with phrase «of calcium channel»

Pimobendan — is an example of a calcium channel sensitiser.

Gingival hyperplasia may also be associated with the use of calcium channel blockers (used to treat cardiovascular disease) and phenytoin derivatives (used to control seizures), though these medications are used far less frequently than cyclosporine in veterinary patients.

Researchers have discovered that a specific type of calcium channel — a pore - like protein that nestles in the cell membrane and controls the flow of calcium into the cell — regulates the relaxation of...

Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.

The pathogenic IgG modified neither kinetics of calcium channel activation nor elementary channel activity, suggesting that a reduction in the number of functional calcium channels underlies the IgG - induced effect.

A study co-led by Ryuichi Shigemoto, Professor at the Institute of Science and Technology Austria (IST Austria), with Alain Marty, Professor at Université Paris Descartes, uncovers that a single docking site may use a single cluster of calcium channels and that both the number of docking sites and the number of calcium clusters change in parallel with brain age.

A cryo — electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.

Not exact matches

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

The researchers found that puffing activated a mechanosensitive channel protein called TRPV4, which is enriched in the membrane of neuronal axons and allows calcium ions to enter the cell.

«It is not yet known whether there's actually an increase or decrease in the flow of calcium ions through the channel,» Olesen says.

Therefore, Lambert - Eaton syndrome IgG reacts with voltage - dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder.

If one component was missing in this triplet consisting of auxin transporter, receptor or calcium channel, there was no cellular response.

This leads to a large increase in the amount of a special calcium ion channel in the nerve cells and overall, this significantly boosts the risk of epileptic seizures.

In fact, the study of additional auxin mutants suggested that both a special receptor complex and a calcium channel were involved.

The N - methyl d - aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage - dependent sensitivity to magnesium and is modulated by glycine.

The researchers also identified the specific neuron responsible for detecting high pH. They did this by showing that when a specific sensing neuron, called the ASH neuron, was destroyed by laser microsurgery, the worms no longer avoided high pH. Going another step further, the researchers also identified some of the proteins involved in the response to high alkalinity, which make up a calcium channel.

Toshihiro Sassa and Takashi Murayama, the first and second authors of the paper, respectively, say, «we would like to identify the other genes involved in downstream signaling from this calcium channel to understand how the signal leads to aversion to high pH.» Sensing alkaline environments is only the first step; the worm must then quickly react to the stimulus by moving away.

The pepper - derived compound creates a sensation of heat in patients who apply the cream by binding to TRPV1s, heat - activated calcium channels that are located on the surface of pain - and heat - sensing neurons.

Calcium ions then travel through the channel, switching on a synthetic piece of DNA the scientists developed to turn on the production of a downstream gene, which in this study was the insulin gene.

Seven of 10 mice exposed to the virus and inoculated with Zoloft one hour later survived, as did all 10 given Vascor, a calcium channel blocker also called bepridil.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signaling.

The team found that the main calcium influx pathway involved in the mineralization of enamel [called the CRAC (Ca2 + release - activated Ca2 +) channel — the main type of SOCE (Store - operated Ca2 + entry) channel — is critical for controlling calcium uptake, which is necessary for the development of tooth enamel.

A team of researchers led by Rodrigo Lacruz, MSc, PhD, assistant professor in the Department of Basic Science and Craniofacial Biology at NYU College of Dentistry, has published a paper in Scientific Reports (5:15803) titled «Dental enamel cells express functional SOCE channels,» which reports the results of a study showing for the first time the mechanism of calcium transport essential in the formation of dental enamel.

The binding of positively charged calcium ions in its vicinity opens the channel and allows negatively charged chloride ions to permeate across the membrane.

The mutation resulted in a lower single channel conductance for calcium and a strongly increased conductance for sodium and potassium, indicating that glutamic acid - 95 is a crucial constituent of the ion selectivity filter.

Structure of the calcium - activated chloride channel TMEM16A.

Coauthor Dr. Stefan Feske, of the New York University School of Medicine Department of Pathology, in 2006 discovered ORAI channels, which open and close to allow calcium into cells.

Prenucleation - stage calcium carbonate clusters provide an early precursor species of different ACC phases giving rise to an alternative crystallization - reaction channel.

The authors show that the voltage gated calcium channels are present on the lysosomes that dispose of proteins.

Voltage-gated calcium channels can not form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release.

This led the researchers to a major conclusion, as Shigemoto explains: «Based on our results, we suggest that for each docking site, there is a corresponding cluster of voltage-gated calcium channels.

«A docking site per calcium channel cluster: Researchers find link between morphology and function of synapses.»

The study is meaningful in respect to the fact that it calls into question the role of the T - type calcium channel in the reticular thalamus, and is expected to provide an important theoretical foundation for understanding its role in the mechanism of absence seizures, as well as developing effective treatment methods for absence epilepsy.

Absence seizures are believed to be elicited by T - type calcium channels in the thalamic reticular nucleus of the brain that regulate influxes of calcium.

«Our study highlights the important role of STIM1 and calcium channels in shutting down the immune response to chronic infection and in preventing injurious inflammation,» Feske says.

They found that the number of functional docking sites matches the number of clusters of voltage-gated calcium channels in the presynaptic terminal.

Specifically, the bipolar neurons expressed more genes for membrane receptors and ion channels than non-bipolar cells, particularly those receptors and channels involved in the sending and receiving of calcium signals between cells.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

«Like in all immune modulatory therapies,» Feske adds, «the benefits of incomplete calcium channel inhibition need to be balanced against the dysregulation of the immune response that results when these channels are blocked completely,»

Researchers at Johns Hopkins have spotted a strong family trait in two distant relatives: The channels that permit entry of sodium and calcium ions into cells turn out to share similar means for regulating ion intake, they say.

The implications of a common control element in sodium and calcium channels are vast, Yue says, including unified understanding of conditions that spring from defects in the calcium control of these channels.

«When we exposed a near - infrared laser beam to these animal models injected with both the nanoparticle and the genetically engineered immune cells, this caused calcium channels on the dendritic cells to open and we saw a corresponding increase in the number of T - cells that were activated,» said Han.

They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal because of an outer shield of amino acids called a turret situated above the channel's entrance.

The induction of synapses required signaling through GABAA receptors and voltage-gated calcium channels and the newly formed synaptic structures rapidly gain functions.

Researchers have known for decades that some microorganisms, such as single - celled green algae, have proteins that respond to light by opening a channel in the microbe's membranes, allowing the passage of electrically charged ions (such as calcium and sodium).

Further research determined that certain components of the cone snail venom, called conotoxins, targeted voltage-gated calcium channels, which, like sodium channels, handle communication between pain - sensing neurons and the brain.

Using a device engineered by Nan Marie Jokerst, Ph.D., a professor of electrical and computer engineering at Duke's Pratt School of Engineering, the researchers showed that UVB caused calcium to flow into the skin cells, but only when the TRPV4 ion channel was present.

Their venom peptides hit a wide variety of pain targets, including sodium channels, calcium channels and other receptors.

«Biochemists uncover structure of cellular memory mechanism: Calcium channel controls thought, movement and metabolism.»