Sentences with phrase «of calcium signaling»

This organic acid has many fundamental biological roles such as conjugation of bile acids, antioxidation, osmoregulation (fluid regulation), membrane stabilization and modulation of calcium signaling.

«A simple trick for modeling calcium: A straightforward technique allows for accurate computer simulations of calcium signaling, a key part of countless biological processes.»

The experiments revealed that the creation of a wound generates a complex series of calcium signals in the surrounding tissue:

Specifically, the bipolar neurons expressed more genes for membrane receptors and ion channels than non-bipolar cells, particularly those receptors and channels involved in the sending and receiving of calcium signals between cells.

Surprisingly, the application of larval oral secretions inhibited the transduction of calcium signals to neighboring leaves in the experiment.

Not exact matches

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

It Is a great source of saturated fat which helps with cardiovascular health, weight loss, absorption of calcium, liver health, nerve signaling (which helps with metabolism and insulin release), supports the immune system, brain and lungs!

The burning in your belly for a double helping of chocolate double latte ice cream may be signaling a need for more calcium or fat.

The speed with which the wave moves suggests that it travels through gap junctions and is made up either of calcium ions or some other small signaling molecule.

«When you measure the two of them together, you can use the strontium - calcium ratio to take away the temperature and that gives you a clear rainfall signal,» explains paleoclimatologist Nerilie Abrams of the British Antarctic Survey.

• What do we know about the nature of the death of massive stars — signaled by Type II supernovae — that fashion crucial elements such as calcium and oxygen?

However, with repeated short - term exposure to capsaicin, those calcium ions essentially close the receptor door behind them, inhibiting further transmission of pain signals.

Toshihiro Sassa and Takashi Murayama, the first and second authors of the paper, respectively, say, «we would like to identify the other genes involved in downstream signaling from this calcium channel to understand how the signal leads to aversion to high pH.» Sensing alkaline environments is only the first step; the worm must then quickly react to the stimulus by moving away.

Latest research from the National Centre for Biological Sciences (NCBS, Bangalore), now shows that maintaining Calcium balance in cells is also needed for another purpose — it may be regulating the levels of an important signalling molecule called dopamine in the brain.

They find that two different stimulus signals can produce two different patterns of calcium waves (that is, two different responses) in an astrocyte.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signaling.

Calcium is a «promiscuous» signal used by all cells for a wide variety of processes, he notes, and thus drugs that target it could have major side effects.

First, looking at a study of 185 cases of childhood epilepsy, Wittkowski's team found that mutations in genes that control axonal guidance and calcium signaling — both of which are important early in the developing brain when neurons are forming the appropriate connections — led to increased chances of having the disorder.

However, Feske and his colleagues found that calcium signals also are required for the development of iTreg cells and that their numbers are strongly reduced in the lungs of the infected STIM1 - deficient mice.

The close temporal association of the [Ca2 +] i transient with the onset of anaphase suggests that calcium may have a signaling role in this event.

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

Neural signals are transmitted within neurons by changing calcium concentrations, so the researchers used this technique to measure the amount of calcium contained within the Purkinje cells in real time.

«What we have found is that the Purkinje cell fills with more calcium when its corresponding climbing fiber sends a signal associated with that kind of sensory input, rather than a spontaneous one,» Medina said.

How calcium signals are elicited in different and separate areas of plants is not yet fully understood.

It was this calcium signal that researchers identified as the trigger of a genetic programme that controls the production of «memory proteins.»

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

Of general importance for systemic calcium signaling is the wounding of the vascular system of the leaf, which is also responsible for the internal transport of water and nutrients in the planOf general importance for systemic calcium signaling is the wounding of the vascular system of the leaf, which is also responsible for the internal transport of water and nutrients in the planof the vascular system of the leaf, which is also responsible for the internal transport of water and nutrients in the planof the leaf, which is also responsible for the internal transport of water and nutrients in the planof water and nutrients in the plant.

Calcium ions are important messengers for the processing of wound signals in plant cells.

Enikolopov says: «If the calcium signal coincides in time with a wave or a puff of nitric oxide — which might be produced even by a neighbouring cell — then this weak calcium signal effectively becomes a strong signal, in terms of its consequences.»

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal because of an outer shield of amino acids called a turret situated above the channel's entrance.

«We succeeded in visualizing the dynamic signal processing of intracellular calcium as a secondary messenger which is elicited by insect feeding and transmitted systemically to unattacked areas of the plant,» Axel Mithöfer, the leader of the project group «Physiology of Plant Defense» in the Department of Bioorganic Chemistry, summarizes the results of the study.

Visualization revealed that calcium signals occur systemically and wander from attacked to neighboring leaves within a short period of time, and ultimately put the whole plant into a state of defense readiness.

The induction of synapses required signaling through GABAA receptors and voltage-gated calcium channels and the newly formed synaptic structures rapidly gain functions.

«Surprisingly, we found that calcium avoidance occurred through two mechanisms: activation of a unique class of GRNs, distinct from those that sense bitter compounds and which cause a stop - feeding signal when activated.

The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells transmit itch signals from the skin to other cells in the spinal cord.

Kummer's group is working in an area that has intrigued biochemists for decades — the role of calcium in hormone - induced cell signalling.

Uncontrolled calcium signaling and ROS in the mitochondria is behind a number of common diseases, such as stroke or heart attack, and is thought to play a role in diseases of aging such as neurodegenerative disease.

The researchers also identified the molecular mechanisms — particularly the role of signals from calcium ions — involved in this effect.

Since calcium ions spike when neurons fire a signal, Yuste and Dupre were able to relate behaviour to activity in glowing circuits of neurons.

Researchers have used this strategy to probe how cells react to the sudden release of signalling molecules, such as the neurotransmitter glutamate and calcium ions.

«Bacterial and host cell proteins interact to regulate Chlamydia's «exit strategy»: New research suggests major role for calcium ion signaling in release of Chlamydia from infected cells.»

Potential future options include solutions that would mimic either benign cysts or tiny bits of calcium called microcalcifications, which can signal cancer.

Therefore, even after genetic elimination of the 5 - HT3 receptor, no other serotonin receptors were capable of generating a calcium signal in the ganglion cells.

Additional experiments showed that genetic disruption of MrcA, depletion of ITPR3, and depletion of STIM1 all significantly inhibited extrusion in infected cells, as did chemical disruption of calcium ion signaling.

These findings suggest an important role for calcium ion signaling in regulating extrusion and could help improve understanding of how the bacterium leaves an infected cell and spreads within the body of an infected person of animal.

As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells.

In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR - driven calcium mobilization and activation of the kinase Erk.

The work combines remote control of action potential firing and synaptic signaling combined with imaging of activity with genetically encoded calcium and voltage sensors and electrophysiology.

Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.

Many functional categories of genes were represented in these analyses, including calcium signaling, cytokines, and growth factor pathways.