Sentences with phrase «of calmodulin»

«The two forms of calmodulin are both powerful, each imposing opposing actions that together maintain exquisite control, akin to the «yin - yang» balance in Chinese philosophy,» Yue says.

Not exact matches

Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + / calmodulin - dependent type I NO synthase of about 150 kilodaltons.

They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

Calmodulin (CaM) is a major effector for the intracellular actions of Ca2 + in nearly all cell types.

The new study revises this viewpoint by devising ways to deliver surges of calcium - free calmodulin to channels.

In so doing, «it can be seen that calcium - free calmodulin is in no way dormant, but instead markedly boosts the opening of calcium and sodium channels to begin with,» Yue says.

In the current model, explains David Yue, M.D., Ph.D., a professor of biomedical engineering and neuroscience at the Johns Hopkins University School of Medicine, calmodulin can do little until it binds to calcium, which changes its shape and snaps it into action.

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.

Now, Dong et al. have investigated the consequences of Dab2 downregulation in a new STEM CELLS Translational Medicine study, demonstrating a novel role for calcium / calmodulin - dependent protein kinase kinase - 1 (CAMKK1) in the modulation of MSC secreted factors and a potential exciting means to enhance MSC - based cardiac repair [2].

Inactivation of the myocyte enhancer factor - 2 repressor histone deacetylase - 5 by endogenous ca2 / / calmodulin - dependent kinase ii promotes depolarization - mediated cerebellar granule neuron survival.

Quantitative Measurement of Ca2 + and Calmodulin - Target Bindings by Fura - 2 and CFP / YFP FRET Imaging in Living Cells.

Molecular interaction and functional regulation of ClC - 3 by Ca2 + / calmodulin - dependent protein kinase II (CaMKII) in human malignant glioma.

Neuron 2013) show that increase in intracellular calcium [Ca2 +] i induced by NMDA receptor activation or membrane depolarization strongly activates AMPK through activatoin of Calcium / Calmodulin - Activated Kinase Kinase 2 (CAMKK2).

NSP2 functions downstream of Nod - factor - induced calcium spiking and a calcium / calmodulin - dependent protein kinase.

Once the cell reaches its destination — the site of inflammation — the calmodulin protein enters the equation to shed the L - selectin protein, allowing it to enter the inflamed tissue.