Sentences with phrase «of cancer cell invasion»

Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.

Thus, in a panel of breast cancer samples, we identified tumor cells that did not form part of the bulk tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer cell invasion.

Not exact matches

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

Activation of beta - arrestin - 1 causes lung cancer cells to produce proteins associated with increased motility and invasion.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

By using «gemcitabine» chemotherapy to target cancer cells, and a form of vitamin A to target the surrounding stromal cells, the combined approach led to a reduction in cancer cell proliferation and invasion.

Instead of displaying the full complement of incriminating proteins on the tumor cell's surface, the dog cancer displays just a few, obfuscating the invasion underway.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

A study in The Journal of Cell Biology uncovers one way that p53 acts to prevent cancer cell invasCell Biology uncovers one way that p53 acts to prevent cancer cell invascell invasion.

The U of G researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin - 22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

«Cancer stem cells are capable of self - renewal, cellular differentiation and maintain their stem cell - like characteristics even after invasion and metastasis.»

EMT is important for cell migration and invasion — two characteristic of metastatic cancer cells — strongly suggesting that the link between lncRNAs and EMT contributes to the metastatic progression of ovarian cancer.

The ability of cancer cells to change position within body tissues through cell migration and invasion represents the biggest threat of cancer to human health.

To test this idea, they experimentally reduced the expression of the DNM30S lncRNA, which resulted in reduced ovarian cancer cell migration and invasion.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

The finding, reported by researchers at Harvard T.H. Chan School of Public Health, Northeastern University, and MIT, provides insights into organ formation in an embryo, healing of a wound, and even invasion of cells into surrounding tissue, as occurs in cancer.

Kruppel - like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.

Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.

MicroRNA -140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2.

Regulation of MMP2 / 9 transport to the invadopodia during breast cancer cell invasion.

Inhibition of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].

GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.

Prostate Cancer: CXCR4 is important for the invasion and metastasis of prostate cancer cells to the bone marrow [32, 38] and it is also a prognostic factor for prostate cancer patientsCancer: CXCR4 is important for the invasion and metastasis of prostate cancer cells to the bone marrow [32, 38] and it is also a prognostic factor for prostate cancer patientscancer cells to the bone marrow [32, 38] and it is also a prognostic factor for prostate cancer patientscancer patients [39].

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

Lysophosphatidic acid and sphingosine -1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three - dimensional organotypic models.

The role and regulation of Rab40b — Tks5 complex during invadopodia formation and cancer cell invasion.

Moreover, mebendazole inhibited invasion and migration of cancer cells in vitro, and formation of metastases in vivo in experimental animals.

University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at anCancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at ancancer that can occur at any age.

«The plasma membrane also dynamically changes shape during cell migration, cancer cell invasion, cell division, nutrient uptake, and entry of pathogens and viruses into cells,» Shin explains.

And we can also use what we know about the genetics of the human cancer to make mutations in normal cells, and see how different mutations drive invasion.»

Research fields include translational research, invasion, metastasis, disseminated tumor cells, transcription, tumor - associated proteolysis, targeted therapy, micro-RNA, molecular staging of cancer.

ABL kinases regulate cancer cell invasion (21), but it is unclear whether they play a role in the regulation of subsequent steps of the metastatic cascade.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte ‐ specific integrin ITGB2.

Epithelial - mesenchymal transition (EMT) contributes to the progression of cancer through enhanced invasion and stem - like properties of cancer cells.

They found that only CAFs were able to stimulate invasion of cancer cells.

Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.

Forced expression of fascin1 in colorectal cancer cells increased their migration and invasion in cell cultures and caused cell dissemination and metastasis in vivo, whereas suppression of fascin1 expression by small interfering RNA reduces cell invasion.

The extent of this cell invasion into the ECM is a key medical marker for cancer prognosis.

The penetration of cells through BM barriers, called «invasion», is an important process during normal tissue development and in cancer metastasis.

Their capacity to contract the matrix and induce invasion of cancer cells has been well documented.

The quantification of local contraction at the micron scale, including its directionality and speed, in correlation with other parameters such as cell invasion, local protein or gene expression, can provide useful information to study wound healing, organism development, and cancer metastasis.

In co-culture experiments on coated transfilters, both NAFs and CAFs induced migration and invasion of HT29, which are intrinsically noninvasive colon cancer cells.

Multiple studies have shown that fascin, through its role in formation of cellular protrusions such as filopodia and invadopodia, enhances cancer cell migration and invasion in vitro.

Cooperation of cancer cells and fibroblasts during invasion.

They also show how this interaction can increase proliferation, migration and invasion of tumor cells, three hallmarks of cancer growth and spread.

A «WOW» maple syrup finding: Take this 2015 study reported in Oncology Reports: the researchers examined the effect of three grades of maple syrup (grades are based on the color of the syrup and ranges from light to darker with color being influenced by time of year and processing technique) on the proliferation, migration, and invasion of colorectal cancer (CRC) cells in order to investigate whether maple syrup is suitable as a phytomedicine for cancer treatment.