Sentences with phrase «of cancer marker»

CancerSeq tissue samples provide researchers with a medium for applications including validation of cancer marker mutation related drug candidates

Not exact matches

Weeks later, Yee realized that he didn't have the equipment he needed to pluck out of Ziskin's blood the rare (perhaps one in 100,000) T cells that could identify the subtle peptide markers on the surface of her cancer cells and attack the disease.

The institute's Tumor Neoantigen Selection Alliance, which includes Bhardwaj's team and others from the University of Pennsylvania and to Stanford Medicine, is focusing on discovering «cancer markers» and then making predictions on neoantigens to combat them.

In clinical trials the treatment — which involves extracting individual patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.

Although a considerable body of scientific evidence substantiates the positive correlation between curcumin consumption and a reduction in the risk of cancer, the paucity of suitably designed human clinical trials that clearly demonstrate any direct effect of curcumin on cancer markers may prevent Health Canada from approving a cancer risk reduction claim for curcumin within the current regulatory framework.

Several researchers, however, are tracking chemical markers in the blood and in the breath with the goal of creating screening tools that could someday not just find cancer but also indicate how dangerous it is likely to be.

«Markers for prostate cancer death can identify men in need of more aggressive treatment.»

Emory's Gabram - Mendola and chemists at the Georgia Institute of Technology have found markers in the breath of 20 breast cancer patients that were not present in the breath of 20 control subjects.

Using data from a randomized trial of 206 men treated with either radiation or, radiation and six months of hormonal therapy, researchers compared early markers of prostate cancer death to identify men at risk of dying early.

Abiraterone's ability to lower levels of prostate - specific antigen, a surrogate marker for prostate cancer, was slightly greater for patients in the low - dose with food group when measured at 12 weeks.

«We want to also investigate whether these two enzymes can serve as an early warning system, a marker of pancreatic cancer risk, in patients with pancreatitis,» Dr. Storz says.

The marker of antigens produced by pancreatic cancer has a low positive predictive value for identifying early stage disease.

Roughly 15 percent of all breast cancer patients have triple receptor - negative breast cancer, which lacks markers for a targeted therapy.

Arnold and collaborators then devised a way to make these WGM biosensors sensitive enough to identify even the smallest individual bio-particles from the RNA virus MS2 to single molecules down to 6 zepto - grams (6x10 - 21grams), below the mass of all known cancer markers.

University Professor of Applied Physics Stephen Arnold and his team at the New York University Tandon School of Engineering have made a discovery that could lead to Star Trek - like biosensor devices capable of flagging the barest presence in blood of a specific virus or antibody, or protein marker for a specific cancer; or sniffing out airborne chemical warfare agents while they are still far below toxic levels.

In particular, they measure the «nuclear - to - cytoplasmic - ratio» (NCR): a recognized biological marker for a wide range of cancers.

The researchers showed that the latest approach to epidemiology worked to track both HIV infections and levels of prostate - specific antigen, a molecular marker associated with prostate cancer.

The population - based study of 503 people with colon cancer found that 14 percent of Caucasians and 7 percent of African - Americans had a genetic marker called microsatellite instability, or MSI.

«The phi test helps physicians distinguish prostate cancer from benign conditions by utilizing three different PSA markers (PSA, freePSA and p2PSA) as part of a sophisticated algorithm to more reliably determine the probability of cancer in patients with elevated PSA levels,» said Kevin Slawin, MD, director, Vanguard Urologic Institute at Memorial Hermann Medical Group, clinical professor of Urology at Baylor College of Medicine and director of Urology, Memorial Hermann Hospital ‐ Texas Medical Center, who performed some of the key research that led to the development of the phi test and who also began using the test in February.

CRP is a marker of chronic inflammation and higher CRP levels have been associated with a higher risk of breast cancer mortality.

Effect of weight loss intervention on inflammatory and metabolic markers in breast cancer survivors.

«Cadherin - 22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,» said lead author Prof. Jim Uniacke, Department of Molecular and Cellular Biology.

There has been a lack of reliable markers, early indicators and risk factors associated with pancreatic cancer, but this new way of differentiating between healthy and malignant tissue offers hope for earlier diagnosis and treatment.»

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

They found that women were five times as likely to develop cancer if they had a higher percentage of Ki67, a molecular marker that identifies proliferating cells, in the cells that line the mammary ducts and milk - producing lobules.

«Our research translates this technological development over to the biosciences and offers the possibility of a new biomedical diagnostics technique capable of detecting the presence of even a single cancer marker molecule.»

All had been treated previously with at least one type of androgen deprivation therapy and had rising levels of prostate specific antigen (PSA), a blood marker for prostate cancer, and radiographic evidence their cancers were becoming resistant.

The team then selected a subset of data for developing a panel for differentiating between pancreatic cancer and healthy pancreas tissue and thereafter applied this «Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the macancer and healthy pancreas tissue and thereafter applied this «Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the maCancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the markers.

Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

Clipped H3.3 may be a marker of cells that stop proliferating and has implications for cancer, in particular cancers like melanoma that have a senescence phase.»

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

While a range of cellular markers of exhaustion, such as PD - 1 and TIM3, have been characterized and are even the target of cancer immunotherapy drugs, the molecular details of how CD8 T cells switch gears were unclear.

The concentration of resveratrol was not associated with inflammatory markers, cardiovascular disease or cancer rates.

Our laboratory is doing that, but it's also looking for markers to help determine which ones never have the chance of becoming cancers in the first place.

Examination of gene expression in patients with non-small cell lung cancer (NSCLC) showed the area adjacent to tumors is rich with cancer markers.

Scientists at The Institute of Cancer Research (ICR) used the cells of fruit flies, modified with a fluorescent marker that is activated when the cells are put under stress, to identify the signals responsible for driving up activity of the ER.

The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.

Comparing the markers on these stem cells with those on the surfaces of cancer cells, Johnson adds, will also help scientists determine if stem cells contribute to prostate malignancies.

Sood and colleagues looked at samples from 80 cases of human ovarian cancer grouped according to patient stress using the National Institutes of Health's Center for Epidemiological Studies Depression scale as a surrogate marker.

People have realized that in order to better diagnose diseases like cancer, he says, you need information from a variety of sources, whether it's fluorescence imaging, optical imaging or biochemical markers.

A selection of Joe Davis's colorful «prayer flags,» which are printed with the code for the genetic markers of diseases such as cancer, Parkinson's and Huntington's.

Although the patients» exposure to cigarettes and other hydrocarbon sources was not integrated with the results, the idea of a marker for lung cancer held up.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

The day for cancer markers will come, but it will take more spending, and it will take a much deeper understanding of carcinogenesis.

In the current study, PCA3 was detected in some, but not all of the study samples, suggesting that reliance on a single biomarker may be insufficient for prostate cancer detection, while combining additional markers may increase the specificity and sensitivity of the test.

The researchers believe that they have identified a group of RNA molecules — known as long noncoding RNAs (lncRNAs)-- that hold the potential for serving as better prognostic markers for prostate cancer.

Strikingly, the same signature was discovered in the blood of women without a BRCA1 mutation but who went on to develop breast cancer, making it a potential early marker of women's cancer in the general population.

«You have blood drawn and that one blood sample can be tested for a comprehensive array of cancer cell markers.

He also hopes that the change in levels of the cancer - related proteins can be used as a marker for which patients are likely to develop cancer in the wake of Barrett's syndrome and which are not in the danger zone.