Sentences with phrase «of cancer stem»

Grant Title: 01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma

Such diets provide a broad approach to cancer prevention because they contain many different compounds that can attack the multiple pathways of cancer stem cell survival.

This theory predicts the existence of cancer stem cells (CSCs) that possess properties characteristic of normal stem cells, such as self - renewal, multipotency and quiescence.

The existence of cancer stem cells has been amply demonstrated for a number of cancer types, including breast cancer (20, 21).

However, scientists disagree on whether the phenomenon of cancer stem cells extends to different kinds of cancer and what is the best way to target them.

We are now studying the mechanics of LepR regulation of cancer stem cell self - renewal.

Sorting breast cancer cells using a new reporter construct allows the interrogation of a highly pure population of cancer stem cells and may allow for the discovery of new therapeutic targets

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

«Using a new technique, we were able for the first time to separate low - PSA and high - PSA prostate cancer cells, which led to the discovery of a low - PSA population of cancer stem cells that appears to be an important source of castration - resistant prostate cancer,» says Tang.

Fighting Cancer: Stem cells have also helped us better understand cancer, through investigation of the emerging idea of the cancer stem cell and the many similarities cancer shares with different members of the stem cell family.

Cancer stem cell database Overview of new public database for identification of characterization of cancer stem cell is described this week in Stem Cells TM.

Herein, we describe the Cancer Stem Cells Therapeutic Target Database (CSCTT), the first online database to provide a rich bioinformatics resource for the display, search, and analysis of structure, function, and related annotation for therapeutic targets of cancer stem cells.

«They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice,» says Friedmann - Morvinski.

«As well as targeting cancer stem cells, we also need to think about how we can prevent the non-cancer stem cells from continually replenishing the pool of cancer stem cells.

The Wnt / beta - catenin pathway regulates self - renewal of cancer stem - like cells in human gastric cancer.

We report the presence of cancer stem cell like Side Population and their survival and enrichment post treatment with bleomycin in HCT116 cell line.

Chemotherapeutic resistance post-surgical management may be linked to an efficient DNA repair mechanism and survival of cancer stem cells.

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

Doubts about the existence of cancer stem cells may have been washed away in 2012, but that has not made things much easier.

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

The characteristic aggregation of lipid - containing structures around the embryonic nuclei clearly detected in C. elegans embryos by CARS microscopy are reminiscent of lipid droplets recently reported to be a characteristic feature of cancer stem cells in colorectal carcinomas (Tirinato et al., 2015).

Our laboratory is interested in exploring the molecular mechanisms that drive the production of cancer stem cells and specifically in dissecting the microRNA / transcription factor circuitry that connects such differentiation metastability to tumour aggressiveness.

Researchers studying the heterogeneous nature of cancer stem cell - containing skin tumors may have discovered new therapeutic targets

Hypoxia - induced Jagged2 promotes breast cancer metastasis and self - renewal of cancer stem - like cells

Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance.

A section of a head and neck tumor — red and green markers show the proliferation of cancer stem cells — that formed when one of several newly characterized genes, Myh9, was suppressed.

A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells.

Since the specific inducers of cancer stem cells, which are key drivers of metastasis, remain elusive, our current findings are a significant advancement in this area.»

Targeting this «wound response» of cancer stem cells can potentially provide a novel approach for therapeutic invention, said researchers from the National Cancer Institute - designated Dan L. Duncan Cancer Center at Baylor College of Medicine.

Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact tumour in a patient.

«This is conclusive evidence for the existence of cancer stem cells in myelodysplastic syndromes,» says Dr Woll.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

We found that the disappearance of protein H1.0 is characteristic of cancer stem cells and it is necessary to maintain the ability of partition and the potential for growth creation.»

«Many chemotherapy drugs leave a small amount of cancer stem cells that cause a renewed outbreak of the disease after a few years.

These findings provide further evidence of ONC201 as an inhibitor of cancer stem cells and support ongoing clinical trials in prostate cancer and glioblastoma that have shown evidence of tumor shrinkage.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancer.

Antibiotics are cheap and readily available and if in time the link between their use and the eradication of cancer stem cells can be proved, this work may be the first step towards a new avenue for cancer treatment.

If the stem cells lose Numb, however, p53 levels plunge and the cells proliferate uncontrollably, leading to the emergence of cancer stem cells that drive the growth of breast tumors.

However, she argues that the results are a breakthrough in cancer research as it may be the first step towards effective treatment of cancer stem cells, i.e. the cells believed to cause metastases.

«Both the natural and the synthetic substances inhibit the growth and spread of cancer stem cells in breast cancer cell lines.

This, in turn, stimulates proliferation of cancer stem cells.

«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.

But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

They find that tumors lacking Numb have increased numbers of cancer stem cells, thus providing the tumor with a higher potential to spread and grow.

The regrowth of cancer stem cells is responsible for the drug resistance that develops in many breast tumors and the reason that for many patients, the benefits of chemo are short - lived.

There is increasing evidence that this is due to the presence of cancer stem cells — cells that reproduce indefinitely and may seed new tumors.

When they prevented the cells from making ALKBH5, NANOG levels and the number of cancer stem cells decreased.