Not exact matches
At rest, women have greater storage
of free FAs than men, but during exercise and conditions
of sustained increased demand, women were shown to exert higher
oxidation of lipids in relation to
carbohydrates.
The adjustment
of energy expenditure and
oxidation to energy intake: the role
of carbohydrate and fat balance.
It is far more likely that other factors, such as the high refined
carbohydrate content
of the Western diet, which triggers inflammation and
oxidation throughout the body, is the most important difference.
To conclude, based on the scientific literature, if your goal is to boost your mitochondrial density and the corresponding degree
of fatty acid
oxidation (fat loss), focus your exercise program around resistance training and HIIT, and formulate a diet that is rich in protein, and low - glycemic
carbohydrates.
The mean fatty acid
oxidation rate was OVER twice the rate
of the high
carbohydrate cohort (1.54 gm / min vs. 0.67 gm / min).
This was a significant concern
of mine as effectively, however the analysis says in any other case: «Coaching with restricted
carbohydrate availability can stimulate diversifications in muscle cells to facilitate vitality manufacturing through fats
oxidation.»
Suffice it to say there is a lot
of biochemistry happening increasing or decreasing the use
of carbohydrates versus fat
oxidation.
Prior to the FASTER study where ALL
of the low carb athletes burned over 1g / min
of fat and NONE
of the high carb athletes reached 1g / min, it was thought that 1g / min
of fat
oxidation limited high performance and the use
of body fat, necessitating carbo loading and a constant stream
of carbohydrate during activity.
A low ratio
of fat to
carbohydrate oxidation is a solid predictor
of future weight gain.
During periods
of high volume and / or intensity
of training including competition concentrated forms
of carbohydrates are brought back into the diet and fueling «strategically» in conjunction with VESPA use to retain the benefits
of high rates
of beta -
oxidation and ketosis while benefiting from the fast metabolizing glucose from the
carbohydrates.
Dr. Brent Ruby was the senior author on a study demonstrating that
carbohydrate utilization is decreased and fat
oxidation is increased during exercise when women are in the luteal phase
of their cycle (1).
When there aren't anymore
carbohydrates left to process (aka all the glucose is gone) your body switches from glycolysis, the pathway by which sugar is converted to energy, to beta -
oxidation, the pathway by which fats, in the form
of fatty acids and glycerol, are transformed into energy.
Consensus statements from leading governing bodies generally recommend that
carbohydrate quantities should range from 3 to 12 g kg 1 body weight.9 - 10 However, recent work suggests that LCHF diets that raise blood ketone levels can increase fat
oxidation rates and markers
of health and exercise performance.11 - 12 In addition to increased fat
oxidation, other potential benefits
of LCHF eating plans for endurance athletes include improved training and racing energy, lowered incidence
of delayed onset
of muscle soreness, reductions in exogenous caloric requirements during training and competition, and the reduced incidence
of serious gastrointestinal complaints.13 Although nontraditional, an LCHF eating plan approach has been recommended for athletes in a variety
of sports for nearly 40 years, 14 and this report is representative
of other cases.
There are also increasing numbers
of reported performance benefits
of lowering dietary
carbohydrate.12, 19,20 Phinney et al. 21 showed enhanced fat
oxidation rates in cyclists who reduced dietary
carbohydrate to less than 50 g per day and substituted calories with dietary fat over four weeks.
Both factors may elicit a sympathetic and hypothalamic — pituitary — adrenal (HPA) axis response, which drive increased systemic reactive oxygen species production, chronic inflammation, and a metabolic substrate shift toward
carbohydrate and away from fat
oxidation, manifesting in an array
of signs and symptoms often labeled as the overtraining syndrome.16
[1] Ketogenic diet benefits body composition and well - being but not performance in a pilot case study
of New Zealand endurance athletes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506682 [2] Ketogenic low -
carbohydrate diets have no metabolic advantage over nonketogenic low -
carbohydrate diets https://academic.oup.com/ajcn/article/83/5/1055/4649481 [3] Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men https://academic.oup.com/ajcn/article/104/2/324/456464 [4] Ketones block amyloid https://www.ncbi.nlm.nih.gov/pubmed/26923399 [5] Ketones Inhibit Mitochondrial Production
of Reactive Oxygen Species Production Following Glutamate Excitotoxicity by Increasing NADH
Oxidation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865572/ [6] The ketogenic diet may have mood - stabilizing properties https://www.ncbi.nlm.nih.gov/pubmed/11918434 [7] The antidepressant properties
of the ketogenic diet http://www.ncbi.nlm.nih.gov/pubmed/15601609
The human metabolic response to chronic ketosis without caloric restriction: preservation
of submaximal exercise capability with reduced
carbohydrate oxidation
The traditional or modified ketogenic diets should not be used in individuals who have fatty acid
oxidation defects, pyruvate carboxylase deficiency, primary carnitine deficiencies, organic acidurias, defects in ketone metabolism, disorders that require high dietary
carbohydrates as part
of their treatment, severe liver disease or hypoglycaemia under investigation (4).
The experimental data gathered by Venables et al. measured
carbohydrate and fat
oxidation in both men and women at various levels
of exercise intensity, where exercise intensity was measured as a percentage
of VO2max.
The investigators wrote, «After 14 d on this [0 %
carbohydrate, 11 % protein, and 89 % fat] diet, 3 h
of hyperinsulinemia were not sufficient to suppress fat
oxidation and increase glucose
oxidation.
I think it is most appropriate to borrow the words from someone far smarter and well versed on this topic here (Dr. Kevin Hall), «A logical consequence
of the
carbohydrate - insulin model is that decreasing the proportion
of dietary
carbohydrate to fat without altering protein or calories will reduce insulin secretion, increase fat mobilization from adipose tissue, and elevate
oxidation of circulating free fatty acids.
The limited number
of studies available suggest that whilst the infused tea might help to improve relative fat to
carbohydrate oxidation, it has no effect on metabolic rate or energy expenditure.
Timmons, B.W., Bar - Or, O. and Riddell, M.C. (2003)
Oxidation rate
of exogenous
carbohydrate during exercise is higher in boys than in men.
Oxidative phosphorylation refers to the complete
oxidation of carbohydrates, fats or proteins.
Many high -
carbohydrate foods common to Western diets produce a high glycemic response, promoting postprandial
carbohydrate oxidation at the expense
of fat
oxidation, thus altering fuel partitioning in a way that may be conducive to body fat gain.
Lactate, which increases during starvation, can induce hepatic ketogenesis.2 Low -
carbohydrate, fat - rich meals can enhance alpha - cell secretion
of glucagon and lower insulin concentrations.3, 4 Plasma fatty acid concentrations can be twice as high during low -
carbohydrate diets as compared with the usual
carbohydrate intake in the postabsorptive period.5 Increased concentrations
of free fatty acids in the absence
of carbohydrate - induced inhibition
of beta -
oxidation of fatty acids and in the presence
of an abnormally high ratio
of glucagon to insulin and elevated concentrations
of lactate may have caused ketoacidosis in our patient, who was trying to avoid all dietary
carbohydrates.
After a few days
of fasting, or
of drastically reduced
carbohydrate consumption (below 50 g / day), glucose reserves become insufficient both for normal fat
oxidation via the supply
of oxaloacetate in the Krebs cycle (which gave origin to the phrase «fat burns in the flame
of carbohydrate») and for the supply
of glucose to the central nervous system (CNS).4
Effect
of diets high or low in unavailable and slowly digestible
carbohydrates on the pattern
of 24 - h substrate
oxidation and feelings
of hunger in humans
While plasma glucose, insulin, and
carbohydrate oxidation did not change significantly, plasma free fatty acid levels rose from 432 ± 31 to 848 ± 135 µEq / liter and were accompanied by significant increases in fat
oxidation during the last hour
of the test.
High rates
of exogenous
carbohydrate oxidation from a mixture
of glucose and fructose ingested during prolonged cycling exercise.