Sentences with phrase «of cardiac stem»

With age, the chromosomes of our cardiac stem cells compress as they move into a state of safe, semiretirement.

A strong regenerative ability of cardiac stem cells derived from neonatal hearts.

Gladstone scientists have discovered how to make the three types of heart cells — cardiomyocytes, endothelial cells, and smooth muscle cells — out of a new type of cardiac stem cell created in a lab.

When comparing the numbers of cardiac stem cells in previously infected adult mice with uninfected ones, the researchers found significantly smaller numbers in the infected mice.

Not exact matches

Starting in 2007, in the same French Institute of Health and Medical Research (INSERM) lab where he did his Ph.D., Catelain worked to harness the potential of embryonic stem cells for treating cardiac diseases.

This image shows an implanted graft of cardiac cells derived from human stem cells (green) meshed and beat with primates» heart cells (red).

A cadre of scientists and companies is now trying to prevent or reverse cardiac damage by infusing a cocktail of stem cells into weakened hearts.

Additional studies will follow to validate the value of stem cell - based regenerative solutions in addressing abnormal cardiac motion in heart failure, ultimately leading to improved patient care.

«The discovery introduces — for the first time — stem cell - based «biological resynchronization» as a novel means to treat cardiac dyssynchrony,» says Andre Terzic, M.D., Ph.D., senior author of the study.

The day after his disciplinary dismissal from University of Tokyo for «damaging the university's honor or credibility,» Hisashi Moriguchi maintained in an interview with ScienceInsider that he really did participate in a groundbreaking experiment to treat a heart disease patient with cardiac muscle cells derived from the patient's own induced pluripotent stem (iPS) cells.

We have found that exosomes and the cargo they contain are crucial mediators of stem cell - based heart regeneration, and we believe this might lead to an even more refined therapy using the «active ingredient» instead of the entire stem cell,» said Eduardo Marbán, MD, PhD, director of the Cedars - Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.

Investigators at the Cedars - Sinai Heart Institute — whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans — have identified components of those stem cells responsible for the beneficial effects.

Only 35 percent reported an ECG in the previous year and 46 percent said they had an ECG in the previous five years, reducing the possibility that the low number of cardiac events stemmed from at - risk runners being screened out before the race.

Theoretically, such stem cells can form any of the body's cell types and could be used in new treatments for Parkinson's disease, diabetes, multiple sclerosis, cardiac disease, and spinal cord injuries.

Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

To test whether the childhood infection and stem cell depletion had any effect on the adult heart, the researchers exposed infected mice to two different types of cardiac stress.

Detailed analysis of the mice after infection showed that the virus does indeed target the heart and is found in cardiac stem cells.

Directed and step-wised differentiation of embryonic stem cells toward neuronal, cardiac and pancreatic lineages

Researchers assessing the cardiac differentiation potential of several adipose - derived stem cells describe an optimal cell source

Now, Dong et al. have investigated the consequences of Dab2 downregulation in a new STEM CELLS Translational Medicine study, demonstrating a novel role for calcium / calmodulin - dependent protein kinase kinase - 1 (CAMKK1) in the modulation of MSC secreted factors and a potential exciting means to enhance MSC - based cardiac repair [2].

A new study suggests that overexpression of SDF1α leads to enhanced stem cell - based cardiac repair of the infarcted heart

A new study suggests that CAMKK1 overexpression in mesenchymal stem cells can potentiate cardiac repair via the modulation of secreted paracrine acting factors

As part of this effort, Xu and her team discovered that growing stem cells under «simulated microgravity» for a few days stimulates the production of cardiac muscle cells, several times more effectively than regular conditions.

They did this not through a cardiac biopsy, but by converting some of the boy's skin cells into induced pluripotent stem cells, and then into cardiac muscle cells.

Furthermore, stem cells in bone marrow may form not just hematopoietic cells, but cardiac muscle cells, neural cells, and other types of cells; this is an example of stem - cell plasticity.

There are many different types of adult stem cells: umbilical cord blood stem cells, bone marrow stem cells, mesenchymal stem cells, endothelial stem cells, cardiac stem cells, muscle stem cells, and others.

At least three types of stem cells were tested for their ability to improve cardiac function: bone marrow derived stem cells (BMSCs), skeletal myoblasts and mesenchymal stem cells (MSCs).

Dr Stephen Minger, a stem cell expert at London's King's College, said Sir Magdi's team were at the forefront of tissue engineering for cardiac disease.

Where treatment strategies have been exhausted, no - option patients may find hope for improvement of their condition with cardiac stem cell therapy for angina.

We accept referrals from physicians as well as inquiries from patients diagnosed with CAD, and of course welcome calls and questions from both physicians and patients about cardiac stem cell therapy and how the treatment is performed.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin - like growth factor binding protein 4 with elastin - like polypeptides.

Our team of cardiologists follows stringent candidacy protocols for patients with heart disease seeking cardiac stem cell therapy.

Researchers find that Insulin - like growth factor / Insulin - mediated induction of mesodermal differentiation aids the production of cardiac progenitor cells from embryonic stem cells towards a strategy to boost cardiac cell production.

SAN FRANCISCO, CA — Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent.

This strip of cardiac muscle was generated from embryonic stem cells that... (Spencer Platt / Getty Images)

Immunocytochemistry / Immunofluorescence analysis of human cardiac stem cells labeling Ki67 with ab16667 at 1/250 dilution.

Now those early results are pointing researchers toward other types of stem cells that may be better suited to help repair cardiac muscle.

Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.

In the example used in this article of the amelioration of cardiac infarcts, the bone marrow «stem cells» have not been demonstrated to do either of these things.

During that time, she applied her knowledge of the processes governing normal heart development to direct the differentiation of embryonic stem cells into the cardiac lineage.

«Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy,» Sadia Mohsin, one of the study authors and a postdoctoral research scholar at San Diego State University's Heart Institute, explained in a news release from the American Heart Association (AHA).

Another remarkable example of cardiac cell regeneration is through what is known as fetomaternal trafficking of stem cells through the placenta.

Stem cells are the pets own natural healing cells that are capable of differentiating into a variety of tissue types including tendons, ligaments, bone, cartilage, smooth and cardiac muscle, liver and others.

There is active research looking at the use of stem cells to treat liver disease, cardiac disease and renal disease.

Researchers are now able to use induced pluripotent stem cells (iPSC) to form a model of human adult - like cardiac muscle by introducing electric and mechanical stimulation at an early stage.