Sentences with phrase «of cell cycle»

Identification of cell cycle - related regulatory motifs using a kernel canonical correlation analysis

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

Today, we know that the retinoblastoma gene product, the RB protein, is a master regulator molecule of the cell cycle.

45) * Coe BP, * Lockwood WW, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer.

After twenty years of research, the cohesin complex still manages to surprise us regularly, as new functions in new areas of cell cycle regulation come to light.

In the 1990s, researchers were beginning to understand the ways cells regulate transitions into the four phases of the cell cycle: G1, synthesis (S) phase, G2, and mitosis.

In my blog post about mitosis (http://www.myscizzle.com/phases-of-mitosis/), I explained some of the challenges a human cell faces when it tries to disentangle its previously replicated chromosomes (for an overview of the cell cycle, see also http://www.myscizzle.com/cell-cycle-introduction/) and segregate them in a highly ordered fashion into the newly forming daughter cells.

Forman - Kay has also found cases where disordered proteins provide precise tuning of cell cycle regulation and protein degradation.

Single - cell transcriptomics on pluripotent stem cells has provided new insights into cellular variation, subpopulation structures and the interplay of cell cycle with pluripotency.

the metabolism of cancer cells, the responses of cancer cells to stress, and mechanisms involved in control of the cell cycle

This blocks promotion of the cell cycle from the G1 to the S phase.

BSI member and senior author, Dr Martin Turner, said, «Our findings shed light on the intricate control and coordination of the cell cycle and show that these binding proteins probably form part of a common mechanism to regulate quiescence, not just one specific to developing B cells.»

ActD has been shown to have a reversible cytostatic effect and the ability to arrest cells in both the G1 and G2 phase of the cell cycle [17].

Validation of a cell cycle progression score for five - year mortality risk in patients with stage I lung adenocarcinoma.

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

Quantification of this data showed that hNSC - derived iPS cells were more similar to hESCs in the percentage of cells in the G2 / M phase of the cell cycle than were hNSCs (Figure S1b).

Topics spanned the entire field of cancer research, from molecular studies of cell cycle proteins to the role of vegetable consumption in cancer prevention.

Here, we are focusing on the regulation of the cell cycle that seems to prevent clonal growth of premalignant stages compared to active myeloma.

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

The large variability associated with the Timer mechanism is well known in the context of the cell cycle, and because of it, the Timer mechanism is not thought to be an appropriate way, on its own, to set stereotyped sizes (Amodeo & Skotheim, 2016).

(B) FACs analysis of the cell cycle in proliferating hNSCs, hESCs, and iPS cells with a chart showing percentages of cell types in the G2 / M phase of the cell cycle.

I am a postdoctoral fellow with the Garner lab employing high - resolution microscopy in live bacteria and archaea towards the understanding of the cell cycle fate.

This system is used to obtain the percentage of cells in each phase (G0 / G1, S and G2 / M) of the cell cycle for each sample.

In the correlation between the Cyclin D1 IOD and the different phases of the cell cycle it was noticed that, there was no any statistically association between Cyclin D1 - IOD and G1 phase % or S phase % in the all of individual groups.

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle.

To address the mechanism of growth inhibition by DDX3, we examined whether the promoter activity and the expression level of the cell cycle regulator p21waf1 / cip1 are regulated by DDX3.

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).

Recently, several RNA helicases, such as RNA helicase A and CHAMP, have been shown to modulate the expression of cell cycle regulator p16INK4a or p21waf1 / cip1 (32, 33).

The Galli group studies the regulation of the cell cycle during development and tissue formation.

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

According to Wikipedia, old pores are disassembled and assembled during different phases of the cell cycle.

Ninov N., Manjón C., and Martín - Blanco E. Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts.

ClC3 is a critical regulator of the cell cycle in normal and malignant glial cells.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1 - Cdk4 controls glucose metabolism independently of cell cycle progression.

Overgrown cultures stimulate quiescence, the resting phase of the cell cycle; quiescent cells do not take up nucleic acid or express transgenes as well as actively dividing cells resulting in lower lentiviral titers.

Ralf Kittler (Buchholz, MPG)-- «Functional genomic analysis of cell cycle progression in human tissue culture cells» (2006)

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

In this new study, licensing refers to origin licensing, the process of helicase loading onto DNA for genome duplication purposes during the G1 phase of the cell cycle.

It is currently suggested that HCECs are held in the G1 phase of the cell cycle and can not pass readily into the S phase prior to cell division [14].

How the vital processes of cell cycle control (with the final event of cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.

[11] Since ABL activates a number of cell cycle - controlling proteins and enzymes, the result of the BCR - Abl fusion is to speed up cell division.

Expression of cell cycle - associated proteins in human and rabbit corneal endothelium in situ.

Check a review on integrative view of cell cycle control in E. coli by L. Dewachter, an article on the return of cultures in microbiology by V. Marx, an article on microbial altruism and cheating in social amoebas by S. Noh.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

In 2001 he was jointly awarded the Nobel Prize for Physiology or Medicine for discoveries of key regulators of the cell cycle.

Bacteria that were smaller at birth and ones that were at the beginning or end of their cell division cycles were most susceptible to antibiotics, while larger cells in the middle of a cell cycle were the most tolerant.

Other studies have shown that the virus is capable of moving into brain cells, modifying the regulation of the cell cycle, and inducing their death.

Recombination refers to the formation of new combinations of genes naturally during meiosis, which is a stage of the cell cycle where chromosomes pair up and undergo exchange.