To address the mechanism of growth inhibition by DDX3, we examined whether the promoter activity and the expression level
of the cell cycle regulator p21waf1 / cip1 are regulated by DDX3.
Recently, several RNA helicases, such as RNA helicase A and CHAMP, have been shown to modulate the expression
of cell cycle regulator p16INK4a or p21waf1 / cip1 (32, 33).
«This idea fits nicely with the findings from a number of groups — that forced expression
of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.
Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role
of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).
Not exact matches
Igoshin said that when the researchers set out to find how sporulation decisions were timed to the
cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity
of the master
regulator gene had been shown to spike once per
cell cycle.
But in addition to these factors, Hunt, who won a share
of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery
of cyclin, a key
regulator of the
cell cycle, emphasizes early independence and playfulness.
This led me to enter the field
of developmental and
cell biology, and to eventually discover cyclin as a key
regulator of the
cell cycle.
All textbooks describe the cyclin - dependent kinase complex as the one and only / exclusive
regulator of the eukaryotic
cell cycle.
In 2001 he was jointly awarded the Nobel Prize for Physiology or Medicine for discoveries
of key
regulators of the
cell cycle.
Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member
of the NF - kappaB / Rel family
of transcriptional factors, is essential for B lymphocyte survival and
cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key
regulator of early activation and proliferation in T
cells.
The
cell cycle regulator p21 mediates the ability
of the tumor suppressor p53 to arrest cellular proliferation.
ClC3 is a critical
regulator of the
cell cycle in normal and malignant glial
cells.
The
cell -
cycle regulator c - Myc is essential for the formation and maintenance
of germinal centers.
SLIMP is an important
regulator of mitochondrial translation that possibly controls the replication status
of mitochondria and somehow ties this process to the
cell cycle.
Today, we know that the retinoblastoma gene product, the RB protein, is a master
regulator molecule
of the
cell cycle.
All CM members have research interests in basic cancer mechanisms, including the normal functions
of oncogenes and tumor suppressor genes;
regulators of cell cycle and apoptosis;
regulators of angiogenesis and metastasis; and stem
cells and blood formation.
These commonly regulated genes clustered into the functional category
of cell -
cycle regulators.