Sentences with phrase «of cell death pathways»

Hear how the rewiring of cell death pathways can sensitize cells to traditional chemotherapy agents.

Not exact matches

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

They specifically applied their model to the Ras pathway, a family of genes that make proteins that govern cell replication and death.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

«Cell - to - cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell - death pathway.&raCell - to - cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell - death pathway.&racell transmission of HIV is absolutely required for activation of the pathogenic HIV cell - death pathway.&racell - death pathway.»

«And cell - to - cell transmission of HIV is required for activation of the main HIV death pathway.»

The researchers» discovery of a control switch that acts on the UPR pathway, published March 25 in the online edition of EMBO Reports, opens new drug development avenues for treating a wide variety of diseases by modulating the UPR pathway to prevent excessive cell death.

The normal function of the UPR pathway is to protect cells from stress but it can also trigger their death if the stress is not resolved.

«The virus evokes a response in the infected cell that activates a pre-programmed cell death pathway,» said Stanley Lemon, M.D., one of the study's authors and a professor of medicine at UNC's School of Medicine and UNC's Institute for Global Health & Infectious Diseases.

Finnish scientists from the University of Helsinki, investigating how Myc re-engineers metabolic pathways in cells, have identified an unexpected branch in the pathway - a branch that ends to cell death (apoptosis).

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

«Research in the last couple of decades has shown that microbes can exploit [cell death] pathways to cause disease,» says study coauthor Tobias Hohl, an infectious disease researcher at Memorial Sloan Kettering Cancer Center in New York City.

The team identified a critical pathway of molecular signals which throw a lifeline to cancer cells, enabling them to survive even though they contain vast DNA errors which would usually trigger cell death.

In this study, the researchers found that macrophages from mice lacking Smurf1 were unable to attach the death - tagging protein ubiquitin to intracellular bacteria, resulting in a failure of the autophagy pathway and runaway growth of the bacteria inside the cells.

The mitochondrial pathway of cell death (apoptosis) starts by permeabilization of the mitochondrial outer membrane which becomes peppered with small holes.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

Minocycline, a synthetic tetracycline - based antibiotic, has shown only limited success as an anti-cancer agent because it promotes the expression of pro-survival Bcl - 2 proteins and, subsequently, can lead to inhibition of caspase - 3 and caspase - 9 activation downstream in the cell death pathway.

But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated.

In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.

Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.

«We wanted to get a better understanding of whether there are any common cell death or cell survival pathways that could be targeted in some of these diseases.»

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou — Cell Death and Differentiation

Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway.

Cell death induced by radiation as well as upon inhibition of these pathways was measured by TUNEL assay using flow cytometry.

Interestingly combined inhibition of ERK1 / 2 or AKT pathways did not show additional cell death compared to individual ERK1 / 2 or AKT inhibition.

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

Remarkably, blood CD4 T cells are resistant to this death pathway, in part because the cells are in a deeper state of rest, meaning the virus is unable to infect them completely, which prevents the onset of the chain of events that leads to pyroptosis.

Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK Death of multiple myeloma cells induced by cAMP - signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584

Our studies will clarify the precise identity of neurons involved by pathology and undergoing cell death in AD, and point to the main molecular pathways that confer vulnerability or resistance to disease.

Previous research from the Greene laboratory revealed that the main cause of cell death in HIV involves a programmed cell death pathway called pyroptosis, where the cells commit a particularly fiery form of suicide in self - defense to prevent the spread of the virus.

During her doctoral studies, Sasha investigated primary human immunodeficiencies, lymphocyte cell death and metabolic pathways as well as memory T cell subsets in the laboratory of Dr. Andrew Snow.

The intrinsic pathway drives cell death by permeabilization of the outer mitochondrial membrane and is regulated by the Bcl - 2 oncogene family of pro- and antiapoptotic factors.

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

For example, new combinations of domains in death-fold domain proteins and laminins possibly allow for the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.

Likewise, unregulated growth, abnormal cell division, and defective cell death pathways are hallmark features of tumors.

Both intrinsic and extrinsic programmed cell death pathways require caspases, a metazoan - specific family of cysteine aspartyl proteases.

Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine - producing nerve cells and ultimately symptoms of Parkinson's...

Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

This research is currently dissecting the proteolytic components of the intracellular pathway that lead to apoptotic cell death.

Dr. Salvesen's research focuses on the central role enzyme pathways play in the life and death of cells.

The blocking of these pathways prevents cancer cell division and results in cell death.

«Oka et al. demonstrated that accumulation of 8 - oxoG in nuclear and mitochondrial DNA triggers two distinct cell death pathways that are independent of each other.»

Similar to the physical and cellular burn of exercise that creates some oxidizing free radicals, the «stress» from cruciferous vegetables stimulates our mitochondria to produce homemade antioxidants to counterbalance the oxidation and protect our vital DNA.28 Even cancer cells have caught on to this central role of our mitochondria — the bastards can amplify their levels of some of these same pathways — further stressing their importance for survival.25 However, our cells still seem to have the upper hand, as multiple studies show that the organosulfur chemicals in many of these anticancer vegetables can severely stress cancer cells, leading to oxidative damage, and ultimately, death.29

Liver disease has been of central importance with aging and programmed cell death pathways.

The disruption of the cell's normal pathway usually leads to cell death.