Sentences with phrase «of cell debris»

«Activation of microglial cells is, on one hand, beneficial for neuronal tissue, as it stimulates clearance of cell debris and prompts secretion of several neurotrophic factors.

Not exact matches

For instance, motion pictures of living brain cells taken through a microscope reveal tiny microglial cells that look like spiders and climb the trunks and branches of neurons cleaning up debris and performing who knows what other functions.
In fact, these dead starter culture cells and debris are an important food source for subsequent generations of microbes, referred to as non-starter lactic acid bacteria (NSLAB).
They also add in hydrated silica as a mild exfoliant to help rid your skin of dead cells, dirt, and debris that could otherwise clog your pores.
His protocol uses progressively higher centrifuge speeds to remove blood cells and debris, and then isolate two different sizes of vesicles.
«Though it turns out that several different cells pick up the slack in the absence of macrophages, it was the neutrophil that emerged as a major contributor to debris removal.
Organisms that surprisingly survived the harsh 7,000 - kilometer journey across the Pacific Ocean on 634 items of tsunami debris ranged from 52 - centimeter - long fish (a Western Pacific yellowtail amberjack) to microscopic single - celled protists.
In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.
Zigmond asked his graduate student, PhD candidate Jane Lindborg, to look for clearance of nerve cell debris in these mice.
«We came up with a list of potential cellular candidates that could be compensating for the loss of these specific macrophages and used several different tests to determine which cells were clearing away the nerve debris after injury,» Lindborg said.
The researchers showed that the synapse - eating process requires a protein in the complement system — a part of the immune response that helps «tag» unwanted cells and other debris for destruction.
With a chip - based microscope, «there's no lens to break,» says Yang, who was inspired by «floaters,» the clumps of dead cells and other debris in the eye.
At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.
«In the best - case scenario, we thought we could hopefully prevent the loss of vision in these patients,» he says, because RPE cells are known to help maintain existing photoreceptors, in part by digesting the cellular debris that they shed.
They prompt the brain's native immune cells, the microglia, to multiply in a bid to dispose of the troublesome new debris.
They clamber through the neurological forest in search of debris from dead or injured cells.
They are recruited to sites of injury or infection and there turn into macrophages (literally «large eaters») that ingest pathogens, infected cells, or cellular debris.
Microglia are present throughout the brain and spinal cord, are constantly monitoring their environment, and can be switched on or activated to perform different functions such as control inflammation, destroy pathogens, clean up the debris from dead or damaged cells, and seal off the site of an injury.
Boulders of water ice and methane debris (red) that have broken off hills surrounding the heart have collected at the boundaries of the cells.
After a four - year experiment with two comparable 533 - tonne samples of municipal waste, the leachate from the wet cell contained dissolved organic particles from food, leaves and garden debris totalling 2700 milligrams per litre.
Microglial cells recognize areas of damage and inflammation and swallow cellular debris.
«This debris left by dead cells can mistakenly signal to the body that there is an infection that warrants immune action, triggering the innate immune system,» said Bruce A. Sullenger, Ph.D., director of the Duke Translational Research Institute.
Two hours later, the electro - phoresis tank has exploded in a ball of flame, the rubber plant has developed epilepsy, and when you finally peer down the microscope your last remaining cell glares up at you balefully through the debris that was once its family, curls up its toes and rolls away to die.
«We also noticed an accumulation of debris of interneurons — the cells that serve as a connection between sensory and motor pathways for reflexes — in the hippocampus, which is responsible for memory storage.»
She recently co-authored a paper with Kantorow and research colleagues titled «Integrin αVβ5 - mediated removal of apoptotic cell debris by the eye lens and its inhibition by UV - light exposure,» published in the Journal of Biological Chemistry.
Evidence suggests that the resolution of infection and thus inflammation is prolonged due to reduced clearance of apoptotic cells and debris by macrophages.11 These age - associated alterations in innate immunity may contribute to increased systemic inflammation termed «inflamm - ageing» observed in aged tissues.10
Moreover, recent data also show that in response to brain damage caused by aging, amyloid deposition, demyelination, and other insults, microglial cells activate several genes, including APOE, in order to more efficiently scavenge and clear tissue debris that are very rich in cholesterol due to the natural composition of the brain, which is mostly made of fats.
The onset and progression of disease in inherited ALS is determined by the motor neurons and microglia, small immune cells in the spinal cord, which migrate through nerve tissue and remove damaged cells and debris.
They also work as garbage collectors, chewing up dead cells and molecular debris strewn among living cells — including clusters of a protein called A-beta, notorious for aggregating into gummy deposits called Alzheimer's plaques, the disease's hallmark anatomical feature.
Through the microscope, scientists could see bubbles of doubled - up membranes — autophagosomes — delivering debris to the cell's degradation center.
cells with high levels of membranous accumulations degenerate releasing cellular debris into the intercellular space and the lumen of the tubules
Scoring - 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiolar and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen.
Perivascular and peribronchial inflammatory infiltrates were observed in most fields along with desquamation of the bronchial epithelium, collections of edema fluid, sloughed epithelial cells, inflammatory cells and cellular debris in the bronchial lumen.
The higher scores (> 3) in some groups related primarily to the fact that virus infection had induced inflammatory infiltrates and epithelial cell necrosis with desquamation of the epithelium and collection of cellular debris in airways of these animals.
In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).
Scoring 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiole and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen.
These effects appear to be linked to progranulin's involvement in phagocytosis, a type of cellular house - keeping whereby cells «eat» other dead cells, debris, and large molecules.
The presence of intracellular pigment granules along with the absence of a subretinal cellular debris zone raise the possibility that these donor cells have (or acquire) the capacity to phagocytose surrounding waste material.
Two related papers with contributions from Huaxi Xu, Ph.D., the Jeanne and Gary Herberger Chair of Neuroscience and Aging Research at Sanford Burnham Prebys Medical Discovery Institute (SBP), show that a protein called TREM2 helps microglia survive and respond more strongly to damaging material like amyloid and cell debris.
This «rejuvenating» effect of young immune cells was mediated in part by the greater efficiency of the young cells in clearing away myelin debris created by the demyelinating injury.
Stimulation of gamma waves reduced levels of amyloid - β, decreased phosphorylation of tau, and led the brain's immune cells — microglia — to perform their usual housekeeping role, clearing away cellular debris, including amyloid - β (as opposed mounting an inflammatory response as microglia do in Alzheimer's disease, Tanzi explained).
The prize was for his work on autophagy, a kind of cellular housekeeping that helps clear the cell of damaged proteins and other potentially toxic debris.
Lemon will also remove the white coating which forms on the tongue during sleep and consists of food debris, bacteria and dead cells and is also responsible for causing bad breath.
«In addition to fungal and bacterial species, bed coverings contain all sorts of microscopic debris including pet dander, lint, soil, dust, dust mites and their droppings, various excrements from the body, skin cells, cosmetics, synthetic chemicals, and other particles.»
The release of reactive oxygen species is also common in inflammaging, and these substances cause oxidative damage to cells and tissues, releasing debris that further elicits inflammation.
The responsibility of collecting and removing pathogens and debris from our brain falls to the microglia, the innate immune cells in our brains.
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In fact, these dead starter culture cells and debris are an important food source for subsequent generations of microbes, referred to as non-starter lactic acid bacteria (NSLAB).
Benefits of Livatrex - It helps cleanse and purify your liver and blood - It is effective in stimulating a sluggish gallbladder - It helps remove excess water and improve liver function - It will stimulate your liver, regenerating new cells and remove excess waste - It promotes the healthy flow of bile from your liver to your gallbladder - It helps flush out excess waste and foreign matter that often overburdens the liver - Helps flush particles and debris from the liver and gallbladder - Contains all organically cultivated herbs
It uses a spoon - like device called a tongue cleaner (although you could also simply use a spoon) to scrape the overnight accumulation of bacterial build - up, food debris, fungi, and dead cells from the surface of the tongue.
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