Sentences with phrase «of cell fate»

In collaboration with experimental groups we use methods from statistical physics to study mechanisms of cell fate regulation in tissue development, maintenance and disease.

The question of cell fate regulation can be asked on different scales.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

Interestingly, centrosomes have also been linked to the segregation of cell fate determinants.

Demonstrated that not a single «master» transcription factor, but rather a combination of factors, are important for reprogramming of cell fate from one somatic lineage back to a pluripotent state.

Although Pdgfrα appears downstream of the fluorescent signal observed here, the dynamic nature of cell fate specification appears similar.

[5] D. Sarkar et al., «Cellular and extracellular programming of cell fate through engineered intracrine -, paracrine -, and endocrine - like mechanisms,» Biomaterials, 32:3053 − 61, 2011.

Now known as a blastocyst, the embryo undergoes a dramatic division of cell fate, forming a distinct outer layer of cells and an equally distinct bulge of about 20 or 30 cells on the inside.

We are currently investigating whether this reflects the progressive resolving of conflict of cell fates, which, in many cases, results in cell death instead of successful lineage reprogramming.

With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?

Such series of cell fate transitions of stem cells ultimately lead to the development of a higher eukaryotic organism.

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

The conference will bring together experts in basic research, with stem cell biologists grappling with the complexity of cell fate determination, bioimaging, and those using stem cells in patients.

Here, we review work that has revealed the central role that physical forces and extracellular matrix mechanics play in the control of cell fate switching, pattern formation, and tissue development in the embryo and how these same mechanical signals contribute to tissue homeostasis and developmental control throughout adult life.

«Transcriptional Reglation of Cell Fate», speaker Dr. Laurie Boyer, Department of Biology, Massachusetts Institute of Technology.