Sentences with phrase «of cell integrity»

The most severe cytopathic effects were observed 48 hours after infection, with a larger number of rounded, swollen cells, more syncytium formation and pronounced loss of cell integrity, all of which denote cell death.

Not exact matches

«Some of the processes tend to be centralized, and in effort to decentralize them while still retaining the integrity of an Iraqi permission [it] was tweaked by the Iraqi government, not by the strike cells, as to who's the Iraqi giving you the thumbs - up that the government has given permission,» Sofge told Business Insider.

Depositing aerated chocolate can be difficult, especially when considering the importance of maintaining the integrity of the cell structure, density and by no means least of all deposit weight accuracy.

Instead, IsoLove re-hydrates tissue to normal, healthy levels, and helps maintain the integrity of the vaginal cell structure and ecosystem.

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

Donald Ingber, M.D., Ph.D., Founding Director of the Wyss Institute at Harvard University, started investigating this «architecture of life» over thirty - five years ago, and discovered that Nature uses an architectural principle known as «tensegrity» (short for «tensional integrity») to stabilize the shapes of living cells and to determine how they respond to mechanical forces.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

When the leaders of the march were arrested, he found himself sharing a cell with Norman Mailer, who described him in his book Armies of the Night as «a slim, sharp - featured man with an ascetic expression, and an air of gentle but absolute moral integrity.»

«This new chip enables us to perform live electrophysiological measurements to assess the integrity of the endothelial barrier in the heart using TEER measurements, while simultaneously quantifying the beating frequency of the heart cells using MEA.

Comprising just 30 letters of genetic code, piRNA are only found within cells in the reproductive organs of animals, where ensuring the stability and integrity of DNA is of particularly vital importance.

Microglia are brain cells that help maintain the integrity and normal functioning of brain tissue.

The authors said these results suggest that LPE «may improve shelf life by maintaining membrane integrity, reducing respiration, and slowing the breakdown of starch and cell walls during ripening and senescence of banana fruit tissue.»

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

«Inhibition of cell division in response to DNA damage enables cells to maintain genome integrity.

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

Hsp genes are a family of proteins produced by cells in stressful situations, ranging from high temperatures to ultraviolet light exposure to maintain genomic integrity.

The team studied skin cells, called dermal fibroblasts, that help hair follicles develop, wounds heal, and generally maintain the structural integrity of skin.

One theory has been that calorie restriction slows age - related degeneration and enables more efficient tissue function by influencing the integrity and activity of adult stem cells, the precursor cells that dwell within specific tissues and give rise to the diversity of cell types that compose that tissue.

«Our finding runs counter to the belief that increasing the reactivity of astrocytes and other glial cells in the brain helps maintain tissue integrity following TBI.

Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine (Centro Andaluz de Biología Molecular y Medicina Regenerativa — Cabimer) have discovered that in eukaryotic cells the proximity of the genes to the nuclear pores, which are found in the nuclear membrane, contributes to maintaining the integrity of the genome.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

«From the MRI we learned of a recovery mechanism in that neural stem cell therapy improves white matter integrity,» said Baker.

Previous work from the Alagramam lab showed that clarin - 1 is essential for maintaining the structural integrity of the hair cells.

«This detection activates cell - signaling pathways that produce antimicrobial peptides, suppress the growth of harmful bacteria, and maintain the integrity of the intestine's epithelial barrier.

«Our hypothesis is that maybe this sort of intrinsic mechanical property — the friction these proteins experience — helps them to get where they need to be, as well as maintain the spindle's organization and mechanical integrity during cell division,» Forth says.

However, it is notoriously difficult to maintain the integrity of cell lines — due to contamination or simple mistakes such as mislabeling, later generations of a cell line may bear no resemblance to the original sample, potentially invalidating results of research performed on mistaken cells.

The authors of the study say their new understanding of how epidermal cells form a barrier may explain the paradox of how we can shed them without compromising our skin's integrity.

The DNA vital to the life of a cell is packaged in chromosomes, and a variety of checkpoints, repair mechanisms, and other cellular safeguards exist to maintain the integrity of the chromosomes during cell growth and division.

The combination of the cells» geometry and tight junction formation means that the skin barrier can maintain its integrity even though it is very thin.

«Our study is also helping us to see how the cells that make up our skin can switch on a mechanism to make a kind of glue, which binds the cells together, ensuring that our skin maintains its integrity.

«With this finding, we have discovered that retinal horizontal cells are required for maintaining the integrity of the retina and that their deficiency can lead to retinal degradation,» explains Mu.

However, because IFN - γ is widely known to influence several endothelial properties, such as junctional integrity (21) and adhesion molecule expression (22), we elected to remove this cytokine from cultures immediately after the second session of cell selection.

First, promising to restore the integrity of science while seeking vast medical benefits for many, President Obama repealed the restrictions set by President Bush on the use of federal funds for embryonic stem cell research.

That means one can devise visual field tests that specifically probe the health and integrity of the OFF cells, so that's what we're doing now.

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou — Cell Death and Differentiation

Annexin V - FITC staining was used as a marker for apoptotic cells, while PI staining was used as an indicator of necrotic cells that had lost membrane integrity.

Cold Spring Harbor, NY — A cell's genome maintains its integrity by organizing some of its regions into a super-compressed form of DNA called heterochromatin.

RHO1 and RHO2 share partially overlapping functions in the regulation of cell wall integrity and hyphal polarity in Neurospora crassa.

To determine how cells maintain the integrity of their genomes, to define the landscapes of cancer genomes, and to facilitate the identification of biomarkers and therapeutic targets.

Within bioprocessing and cell bioprocessing applications, guaranteeing the integrity of your product is critical.

The long term functionality and integrity of many organs depends critically on the function of resident stem cell populations.

In May 2016, the ISSCR developed guidelines to help protect the integrity of stem cell research and assure the public that it will proceed efficiently and remain responsive to public interests.

Aging results in a decline in the integrity and function of cells and tissues.

The mutant mice had fewer myocardial cells and disruptions of the muscle integrity that eventually led to prenatal death.

Restoration of the integrity and adhesion of these cells prevents protrusion of the underlying cells into the spinal canal where they block circulation of the cerebral spinal fluid.

The researchers also discovered that the integrity of synapses was preserved much better in the olive oil group and the brain tissue of the mice that fed olive oil had increased autophagy activation of the nerve cells.

Adult stem cells ensure maintenance of the tissue and integrity in response to damage.

A series of new mouse models have recently been developed in the laboratory that will allow us to dissect how DNA damage, oxidative stress and chromatin remodeling impact on mitochondrial integrity and stem cell decline during aging.

* Acute promyelocytic leukaemia is caused by the modification of two genes, RAR and PML, leading to the development of cancer cells; ** the gene coding for p53 protein plays an essential role in cell proliferation under normal conditions and in maintaining the integrity of the cell genome.

Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.