Sentences with phrase «of cell pathways»

The discovery highlights the need to consider ROS molecules not just as protein - wrecking machines but as links in the chains of cell pathways, Dr. Blackwell says.

Not exact matches

Still, researchers now have a far better understanding of the molecular pathways in the ear and how to regenerate hair cells and repair synaptic connections.

The challenges of finding an alternative to FBS, bringing costs down massively, speeding up cell growth, and finding an appropriate regulatory pathway, have compounded one another.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway - which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells - has been traced for the first time in a major hypothesis paper in Cell this week.

I could, however, talk to you about the major metabolic pathways of the cell or the wave functions of particles.

December 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the...

Origin of Life: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

ORIGIN OF LIFE: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeOF LIFE: Hypothesis Traces First Protocells Back to Emergence of Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof Cell Membrane Bioenergetics Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this weeof living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

Dec. 20, 2012 — A coherent pathway — which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells — has been traced for the first time in a major hypothesis paper in Cell this week.

Recent findings from the University of Texas MD Anderson Cancer Center suggests that capsaicin, the active chemical compound that gives chile peppers their heat, may reduce and even block chronic inflammation pathways in cancer cells.

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

This simply means exposing kids to a wide variety of tastes, smells, textures, colors, and sounds — experiences that can create more pathways between the cells in their brains.

Milk ducts found between fat cells and the glandular tissue also grow in number and size creating a complex web of pathways throughout your breast leading to your nipples.

The trophoblast is the outer layer of cells of the blastocyst which allow the fertilized ovum to attach to the uterus and which serves as a nutritive pathway for the embryo.

Colostrum is characteristically high in sodium (> 30 mmol / L) and low in potassium (< 15 mmol / L) as a result of open paracellular pathways between mammary epithelial cells [14].

This pathway also could be relevant in conditions involving loss of cells that make this insulation, like multiple sclerosis.»

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

They wanted to find out whether this particular pathway — a longtime focus of Imai's lab — is important for these cells or if the other routes could compensate.

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

When the stem cells were around three days old, researchers added a cocktail of proteins including Noggin, which suppresses that pathway, and timed doses of retinoic acid, a compound in vitamin A.

«Because BX795 targets a common pathway that many viruses use to replicate inside the cell, it could be a new kind of broad - spectrum antiviral that might be used to treat other viral infections, including HSV - 2, which primarily affects the genitals, and HIV, although we have not yet tested it on viruses other than HSV - 1.»

At low doses of cocaine, the GAPDH in the nucleus will stimulate the neuron, but at higher doses it activates the cell's self - destruct pathway.

The researchers identify the cause of this increased production in inflammatory cells and find that blocking this new pathway could help safeguard the heart health of diabetic patients.

These give us important clues as to which biological pathways are involved in controlling the production, function and characteristics of blood cells.»

Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.

When the researchers did the opposite, turning on a PAK protein in a metastatic melanoma cell line, they found the cells became even more resistant to inhibitors of the MAPK pathway.

At the synapse, where two neurons meet, Montague says, «It takes very sophisticated fluorophores to mark pathways inside and outside of the cells.»

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles on a detour route, make use of additional pathways to continue growing and spreading.

They specifically applied their model to the Ras pathway, a family of genes that make proteins that govern cell replication and death.

In a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cells.

Meanwhile a team led by Yihong Ye, a cell biologist at the National Institutes of Health, discovered another pathway that uses different protein workhorses to accomplish a similar off - load.

Overexpression of ZNF217 provides an advantage to tumor cells by allowing cells to infinitely proliferate and turning down pathways that typically tell cells to mature into functional cells (bone, blood, skin cells).

In the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammation.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

Working in Berkeley, Lundblad discovered that even without telomerase, yeast cells can sustain their chromosome tips — the first example of an alternative telomere - lengthening pathway.

Hormones regulate a lifelong reshaping of our neuronal pathways, programming a turnover and pruning of brain cells — a process that begins in the womb and continues to affect our intellectual, emotional and social development in adulthood.

Engineers are well - equipped to sketch so - called wiring diagrams of biochemical pathways that lead to aberrant cancer cells.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

Schwarz and her colleagues used three different drugs, alone and in combination, to deprive cervical tumors of glucose and block downstream metabolic pathways that help protect cancer cells from building up toxic free radicals.

Liu acknowledged that study does not explain why disruption of the CLOCK pathway reduces the inhibitory current within the cells after it arrives via their connections, or «synapses,» with other neurons in their circuits.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

Deletion of LKB1 in regulatory T cells disrupted metabolic pathways that support the health and function of the mitochondria.

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

Myelin protects the neural pathways and is thus essential to the ability of nerve cells to transmit information.

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

Other research groups are also generating promising results through the use of drugs to convert white fat cells into brown fat and through discoveries of the pathways and hormones that control brown fat metabolism.