Sentences with phrase «of cell plasticity»

For example, adjuvant therapies that inhibit this type of cell plasticity may be a very effective way to keep metastasis at bay.»

Not exact matches

«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly increasing the growth of new neurons and cell survival, enhancing memory and learning, and increasing molecules that are involved in the plasticity of the brain,» Chaddock said.

They found that exercise may help cognition by increasing blood and oxygen to the brain, increasing levels of norepinephrine, and endorphins to decrease stress and improve mood, and increasing growth factors that help create new nerve cells and support synaptic plasticity.

«There is still a long way to go before diabetes patients might be able to benefit from these findings, but the discovery that delta cells have a high degree of plasticity points to a hitherto unsuspected option for therapeutic intervention.»

According to Bean, study co-author Alexander Binshtok, a Harvard postdoctoral researcher in neural plasticity, is already at work eliminating capsaicin's negative effects by reversing the order of the injections: leading with QX - 314, quickly followed by capsaicin to shove it through the cell.

Dr. Monteggia's lab focuses on the molecular and cellular bases of neural plasticity, the fundamental property of nerve cells to alter their communication, as they pertains to neuropsychiatric disorders, as well as understanding the mechanisms underlying antidepressant efficacy.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

Moser demonstrated a number of changes in the strength of connections between nerve cells — a phenomenon called synaptic plasticity — in the hippocampus as rats stored information in their long - term memory.

The work, which appears in the journal Cell, focuses on the regulation of «neuronal plasticity» — changes in neuronal structure — and its function in the brain.

But there are also neural stem cells as well as early progenitors that have this plasticity in most of the other systems of the body.

Cellular plasticity is the ability of a cell to make different cell types.

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from «neuronal plasticity» — the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

The single cell and the two cells resulting from it, have the highest level of cellular plasticity: They are totipotent, which means they can make a full organism, including the extra-embryonic placental tissue.

«Our results suggest that the location of the translational hotspot is a regulator of the simultaneous translation of multiple messenger RNAs in nerve cell dendrites and therefore synaptic plasticity,» says Sul.

Scientists have been attempting such a feat for years, refining their methods along the way, and the Irvine team finally saw success: the cells were integrated in the brain and caused large - scale rewiring, restoring the high - level plasticity of early development.

It is not yet known whether the proliferation of the transplanted cells accounts for the restored plasticity or if the new cells trigger plasticity in existing neurons.

The mTOR protein is part of a complex that carries out a multitude of functions within cells, including the formation of synapses — the connections between neurons — their maintenance and plasticity.

The mTOR protein is part of a complex that carries out a multitude of functions within cells, including the formation of synapses ---- the connections between neurons ---- their maintenance and plasticity.

Using cell culture assays and genetically modified mice, we identified a number of signaling proteins that participate in muscle plasticity.

In thinking about what molecules on the surfaces of cells had both the plasticity and molecular complexity to explain developmental programs, I knew it had to be the glycans.

Professor Martin's research focuses on the cell biology of transcription - dependent forms of synaptic plasticity, particularly those underlying learning and memory.

When the researchers modeled the effects in mice, they found it strengthened the connections between neurons that make learning possible — what is known as synaptic plasticity — by increasing the action of a cell receptor critical to forming memories.

For the type I interferon (IFN) receptor (IFNAR) as a paradigm for functional plasticity, we have, within the first funding period, established single molecule imaging techniques for monitoring receptor assembly and dynamics in the plasma membrane of living cells.

We use the fission yeast, Schizosaccharomyces pombe, to study the dynamic changes and plasticity of gene expression programs as a function of cell proliferation, quiescence and ageing, and the effect of various genetic and environmental perturbations.

The understanding of cell identity, heterogeneity and plasticity in neuroblastoma has strong implications with respect to the development of new therapeutic strategies to eradicate tumor cells in neuroblastoma patients.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

To identify the molecular mechanisms of neural stem cell plasticity in adult zebrafish brain after various types of tissue damage or physiological stimulations

Furthermore, stem cells in bone marrow may form not just hematopoietic cells, but cardiac muscle cells, neural cells, and other types of cells; this is an example of stem - cell plasticity.

These findings suggest that regenerating organisms such as zebrafish could use special molecular programs to modulate the plasticity of the neural stem cells and enable restoration of compromised neural tissues.

Researchers have discovered a new form of synaptic plasticity, the changes to nerve cells in the brain that underlie learning and memory.

Molecular mechanisms of stem cell plasticity and regenerative neurogenesis in adult zebrafish brain

Cédric Maurange, 2nd Call 2010 Institute of Developmental Biology of Marseille - Luminy Neural stem cell plasticity in Drosophila [email protected] [phone]

Stem cells have the plasticity to potentially differentiate into any type of tissue cells.

Allogeneic cell transplantation enables the use of «younger» cells, from fetal origins (e.g., umbilical cord blood, placenta) or healthy donors, which are considered to be effective due to higher regenerative potential and plasticity.

Their work could pave the way for more effective prevention of heart attack and stroke in humans caused by atherosclerosis, in which artery walls thicken and suffer reduced plasticity due to an accumulation of white blood cells.

Title: «Hearts and bones»: the ups and downs of «plasticity» in stem cell biology Authors: Bonfanti P, Barrandon Y, Cossu G Date: 2012 Publication Details: EMBO MOlecular Medicine 2012 May 4 (5): 353 - 361

TAD dynamics displayed signs of elevated plasticity at later stages of reprogramming, as cells attain pluripotency

The researchers say the special «plasticity» of the blood stem cell that allows them to be transformed to a heart cell, holds important clues about how leukemia and other blood diseases develop and how they can be controlled.

But novel genomic tools are beginning to reveal new, rare cell types as well as unexpected variability and plasticity within groups upending the traditional view of immune cells assigned to the same category as unvarying entities that behave in a constant manner.

Dr. Dean Tang Receives Sanofi - Cell Research Outstanding Paper Award (11/04/2013) Dr. Dean Tang of the Department of Epigenetics and Molecular Carcinogenesis received the 2012 Sanofi - Cell Research Outstanding Review Article Award for his review paper entitled, «Understanding cancer stem cell heterogeneity and plasticity,» published in March, 2Cell Research Outstanding Paper Award (11/04/2013) Dr. Dean Tang of the Department of Epigenetics and Molecular Carcinogenesis received the 2012 Sanofi - Cell Research Outstanding Review Article Award for his review paper entitled, «Understanding cancer stem cell heterogeneity and plasticity,» published in March, 2Cell Research Outstanding Review Article Award for his review paper entitled, «Understanding cancer stem cell heterogeneity and plasticity,» published in March, 2cell heterogeneity and plasticity,» published in March, 2012.

A specific attention will be given to the identity, plasticity and differentiation potential of the cells required for the regeneration processes.

Chronic fluoxetine stimulates maturation and synaptic plasticity of adult - born hippocampal granule cells.

In general, adult stem cells have low plasticity, although reports of differentiation outside traditional lineage boundaries suggest that some adult stem cells may be more pluripotent rather than multipotent.1

Nanog is a critical factor required for what cell biologists call «stemness,» which is defined by two qualities: the ability of ES cells to divide or «self - renew» and their plasticity in assuming the identity of almost any cell type, which is also known as «pluripotency.»

The view of ES cell transcriptional regulation that emerges from these studies encompasses plasticity but nevertheless envisions lineage commitment and loss of pluripotency as an all or nothing switch.

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

Thus, although such genomically deranged conceptuses are unlikely to survive much beyond the implantation phase of pregnancy, the relatively large fraction (∼ 72 %) of successful pregnancies obtained at d 20 with cell line 5538 (19) suggests that there is significant plasticity in gene expression that can lead to successful implantation.

«These experiments with cell type - specific pharmacology provide direct evidence for the necessity of NMDA - Rs in dopamine neurons for the synaptic plasticity observed 3 - 5 hours after exposure to cocaine in vitro, leaving open the molecular explanation for the potentiation AMPA - Rs that occurs after many days of NMDA - R inactivity in dopamine neurons in vivo.

a) In the subsection «Cell type - specific NMDA - R pharmacology in cocaine - induced synaptic plasticity» we now more clearly introduce the Zweifel and Engblom studies as well as the differences between them: both of which used genetic ablation of Grin1 over 1 week but showed different results with respect to DA neuron synaptic potentiation, which was due to methodological challenges with AMP - R compensation.

2) The description of Engblom et al., 2008, in the subsection «Cell type - specific NMDA - R pharmacology in cocaine - induced synaptic plasticity» is misleading.