Scientific evidence suggests that people with existing breast tumors are vulnerable to the effects of atrazine exposure, because atrazine may increase the
rate of cell proliferation in existing estrogen - receptor - positive breast tumors, due to its capacity to convert androgens to estrogens.
In the case of planarians, the gene egr - 4 seems to perform an early
control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.
EGFR is an important driver
of cell proliferation in the intestines, whose epithelial lining is replaced approximately every four to six days.
We use the fission yeast, Schizosaccharomyces pombe, to study the dynamic changes and plasticity of gene expression programs as a
function of cell proliferation, quiescence and ageing, and the effect of various genetic and environmental perturbations.
Burgener et al. «Fluoride Increases Tyrosine Kinase Activity in Osteoblast - Like Cells: Regulatory Role for the
Stimulation of Cell Proliferation and Pi Transport Across the Plasma Membrane», Journal of Bone and Mineral Research, 10 (1): 164 - 171, 1995.
New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological
programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.
These biochemical mechanisms influence four different actions, which are cellular apoptosis, the
inhibition of cell proliferation, the suppression of cytokine production and the reduction of white blood cells or leukocytes.
«I think that we've produced a 3 - D microenvironment which is much more like that found in vivo for growing embryoid body, which explains the higher
levels of cell proliferation.»
Calcium and DAG activate protein kinase C, which, in turn, activates the MAPK and PI3K / AKT pathways which allow the
upregulation of cell proliferation and anti-apoptosis signals [42].
Professor Matthias Trost at Newcastle University along with colleagues at Dundee University investigated the drug's mode of action in more detail and uncovered the proteasome, a cellular degradation machinery vital for the control
of cell proliferation, as its yet unknown target.
PI3K / AKT / mTOR is considered to be a central regulatory pathway of protein translation involved in the regulation
of cell proliferation, growth, differentiation, and survival (11, 26, 30).
At least 200 human genes contain vitamin D response elements (33); many of these genes encode for proteins important in the regulation
of cell proliferation, differentiation, and apoptosis.
Inhibition
of cell proliferation (B) of MCF7, MCF7 / HER2, or BT474 cells treated for 6 days with F3 - IgG, trastuzumab, or isotype control antibody.
Therefore, it is difficult to conclude on a universal correlation between MELK expression and the rate
of cell proliferation.
Because Wnt signaling is involved in the regulation of proliferation and apoptosis, and miR - 150 is reported to regulate proliferation of breast cancer cells, we think that the functions of these microRNAs include the regulation
of cell proliferation and apoptosis.
The regulation
of cell proliferation and the suppression of apoptosis are a part of the self - renewal abilities that characterizes stem cells.
(High levels
of cell proliferation is a marker for breast cancer.)
Inhibition
of cell proliferation and in vitro markers of angiogenesis by indole -3-carbinol, a major indole metabolite present in cruciferous vegetables.