Sentences with phrase «of cell replacement»

Although this possibility has not yet attracted as much attention as the ideas of cell replacement, personalized medicine and other more direct clinical applications, hESCs are expected to be superior to most commonly used cell - culture models of drug discovery which employ tumor - derived or immortalized cell lines or primary cell culture.

Beyond Type 1 Provides Grant to ViaCyte to Support Research and Development of Cell Replacement Therapies for Type 1 Diabetes

The initial phase of clinical investigation is focusing on the safety of the cell replacement therapy combination products in patients.

There are now multiple immunotherapies targeting clearance of alpha - synuclein from the brain in early - stage clinical trials, and multiple trials underway or in the works on the next generation of cell replacement therapies for dopaminergic neurons, including the TRANSEURO trial; the Summit4StemCell initiative, put together by Jeanne Loring — a researcher at The Scripps Research Institute who is exceptionally engaged with turning her research into therapies; a Japanese trial to be run by Jun Takahashi of Kyoto University in Japan (cf. here and here); and a trial centered at Memorial Sloan Kettering Cancer Center headed by cell biologist Lorenz Studer.

Our research goal is to understand the molecular and cellular events required for pancreatic β - cell regeneration, and apply this knowledge towards the development of cell replacement therapies for diabetes.

For the first time, researchers demonstrate long term success of a cell replacement therapy using autologous induced pluripotent stem cell derivatives

Not exact matches

He earned degrees in cell biology and tissue engineering and eventually got a job in a lab run by Vladimir Mironov, who was investigating the use of bioprinting — 3 - D printing using living cells — to generate replacement organs.

«We die daily»: so it is often said, not only with reference to the death of our bodily cells and their replacement by other cells every few years, but also in respect to our possible human growth.

Duly reverential, the panel satisfied itself with simply listing all the research possibilities, including the improvement and increased safety of IVF, the creation of cell lines that might someday be useful for bone marrow transplantation, repair of spinal cord injuries, skin replacement and, naturally, the hint of a greater understanding of cancer.»

But some of the cells eventually run out of steam, and can't muster another replacement cycle.

There are hopes in the medical community that stem cell research and therapeutic cloning will facilitate organ cloning and enable the replacement of damaged cells with healthy ones for sufferers of degenerative diseases.

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

Da Cruz and his team grew replacement RPE cells from human embryonic stem cells on a thin plastic scaffold, before transplanting the tissue into the back of each volunteer's eye.

A new type of human stem cell, never seen in nature, should be better at making replacement organs than existing stem cells

Both diseases result from the death of retinal cells, a process that Lanza suspects can be slowed or even halted using stem - cell - derived replacements.

«This research has broad impact, because by deepening our understanding of cell reprogramming we have the potential to improve disease modeling and the generation of better sources of patient - specific specialized cells suitable for replacement therapy,» said Plath.

On average the transplanted stem cells regenerated 40 percent of the damaged heart tissue, said Dr. Michael Laflamme, UW assistant professor of pathology, whose team was principally responsible for generating the replacement heart muscle cells.

Researchers expect stem cells to transform into replacement tissue capable of replacing damaged cells.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

OHSU scientists have also demonstrated that SCNT allows replacement of mutated mitochondrial genes with healthy donor egg mitochondria while retaining the patient cell's nucleus.

Their major hurdle: to come up with a replacement for hemoglobin (an iron - enriched protein in red blood cells that transports oxygen from the lungs to the rest of the body) that can be directly introduced into the human circulatory system.

The recipe for these replacement organs begins with destruction: Wash away the cells of a donor organ with detergent, leaving behind just its spongy, protein support structure.

In order to overcome the limited ability of the neurons of the adult nervous system to regenerate spontaneously, cell replacement strategies employing embryonic tissue transplantation show attractive potential.

And our normal tissues would be preserved intact, provided that we underwent regular rounds of replacement of stem cells.

The extra bone that appears in FOP flare - ups progresses through a cartilage stage before replacement with mature bone cells, following a sequence of bone formation seen during normal skeletal development.

We know that mitochondria do more than simply power our cells, but in a recent New Scientist piece, Robin Lovell - Badge from the MRC National Institute for Medical Research in London explained why none of these «extra» functions are relevant to mitochondrial replacement.

These cells, in turn, instruct factor - VIII — specific immune cells to become tolerant to the coagulation protein, resulting in suppression of misdirected antibody responses to the replacement therapy — all without affecting the rest of the immune system.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

Nevertheless, he thinks this sort of technology will be seen in the clinic before a treatment based on a stem cell replacement for photoreceptors.

But for cell replacement therapy to realize its potential, I anticipate that scientists must solve the developmental code, the set of rules that govern the formation of tissues, organs, and beings from the original single cell — the zygote.

There is evidence that chronic disabilities such as spinal cord lesions, diabetes, and Parkinson?s disease, where replacement of just one cell type restores tissue function, can be treated with differentiated embryonic stem cells.

Most of the BMBF's support for stem cell research is channelled through two priority programmes: «Biological Replacement of Organ Functions» and «Tissue Engineering».

The result — the second such finding in the past year — suggests that similar cells from human testicles might have similar powers, paving the way to creating replacement tissue for men who have suffered damage from heart attacks or other injuries and avoiding some of the controversy surrounding embryonic stem cells (ESC).

The new approach builds on information gleaned from developmental studies of embryonic stem cells (see story # 16) and one day may be used to create healthy replacements for harmed or diseased tissue.

Researchers at the University of Minnesota have developed a new, carbon - neutral way to convert vegetable - based fuels to syngas, a breakthrough that could allow producers to power hydrogen fuel cells or create a replacement for America's dwindling supplies of natural gas, all without relying on fossil fuels.

IFN - I triggers many different immune responses, but can also speed up the replacement of epithelial cells.

Five to seven years down the road, he predicts, patients recovering from spinal fusion or joint - replacement operations will have some of their own fat cells removed, processed, and implanted at the same time as other surgical procedures.

For example, one of the goals of stem cell research is to develop methods for the replacement of damaged tissues in the future.

Atala wondered whether it would instead be possible to remove bladder cells from a patient and use them to grow a replacement organ, thus eliminating the risk of transplant rejection.

In self - renewing tissues, such as the skin, chromatin modification is also involved in regulating the replacement of old or damaged cells in later stages in life.

«For the broad application of stem cell - derived pituitary cells in the future, cell replacement therapy may need to be customized to the specific needs of a given patient population,» Zimmer says.

In addition, the sources of the replacement nuclei were the egg donors» own cumulus cells, which encircle developing eggs in the ovary.

Researchers at the Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham, have just finished the first stage of development, which draws on research showing that human skin cells produce chemicals called cytokines when exposed to chemicals that are irritants.

Instead of being cleared away for replacement by new, healthy cells, the old, defective cells become useless clutter, producing chemicals that cause harmful inflammation.

Replacement tissue that avoids rejection by a patient's immune system is a step closer to the clinic, as researchers have created human embryonic stem cells carrying the DNA of specific adults.

«It would defeat the purpose of doing mitochondrial replacement,» says Dieter Egli, a stem - cell scientist at the New York Stem Cell Foundation Research Institute who led the wcell scientist at the New York Stem Cell Foundation Research Institute who led the wCell Foundation Research Institute who led the work.

An EU - funded research project («HumEn»), in which Lickert and his team are participating, shall provide further insights in the field of beta - cell replacement therapy.

With these findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem cell differentiation which could be used for beta cell replacement therapy in diabetes.

But Mary Herbert, a reproductive biologist at the University of Newcastle, UK, who is part of a team pursuing mitochondrial replacement, says that mitochondria behave very differently in embryonic stem cells compared to normal human development.

Before scientists and engineers can realize the dream of using stem cells to create replacements for worn out organs and battle damaged body parts, they'll have to develop ways to grow complex three - dimensional structures in large volumes and at costs that won't bankrupt health care systems.