Sentences with phrase «of cell signaling pathways»

Luteolin decreased activation of the cell signaling pathways Akt, PI3K, and CDC25c and ERK1 / 2 that are dependent on IGF - I.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

The results, which were published and highlighted in Molecular Systems Biology, give researchers a more complete view of cell signaling pathways.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

But that didn't pinpoint the site of computation; cells earlier in the pathway might be analyzing motion and delivering a larger excitatory signal to the ganglion cells in response to movement in the preferred direction.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

Trametinib is used to treat skin cancer and was chosen for its ability to inhibit Ras signalling as part of the «Ras - Erk - ETS» cell pathway.

I found that culturing cardiac valve cells on synthetic hydrogels preserves their normal properties better than the traditional plastic plates do, and I discovered a signaling pathway connecting the stiffness of the supporting scaffold to the cells» cytoskeletal structure.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

The cells of such different organisms as roundworms, flies and humans use the insulin / IGF signalling pathway.

Over several years, Dr. Stewart and colleagues unraveled genes and signaling pathways that drive multiplication (proliferation) of beta cells, and then confirmed proposed mechanisms with gene therapy.

A signaling pathway is how developing cells get instruction on what types of cell to become, such as a liver cell, a skin cell, a brain cell, etc..

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

The daf - 2 gene is also part of a signaling pathway that influences how well cells age and cope with stress.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

A signalling pathway is a biological method of transferring information, and via those pathways, the cell can respond to external conditions like the state of food supply.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

«In my opinion, age is just a number, and it's not a chronological number of years, but a number representing the strength of signaling pathways within cells,» Conboy says.

The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K / AKT / mTOR, upon which the leukemia cells have become dependent.

The discoveries achieved during this project, which was funded by the Rosetrees Trust of Britain, were published this week in the journal Aging Cell («A novel inhibitor of the insulin / IGF signaling pathway protects from age - onset, neurodegeneration - linked proteotoxicity»).

Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

Meanwhile, fertilisation of the egg cell activates its «ethylene signalling» pathway, which degrades the nucleus of the persistent synergid cell.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.