Sentences with phrase «of cell surface antigens»

Heterogeneity in human ES cultures is reflected by the variability in expression of cell surface antigens seen under culture conditions that promote stem cell renewal.

These compartments of cells can be resolved on the basis of their expression of cell surface antigens.

Human MSCs are defined by positive expression of the cell surface antigens CD73, CD90, CD105 and by absence of expression of hematopoietic antigens, including CD11b or CD14, CD34, CD45, CD79 or CD19, and HLA - DR.

Not exact matches

Antigens are proteins on the surface of blood cells that can cause a... Continue Reading →

The expert answers: «Having Rh negative blood means that a protein, the D antigen, is not present on the surface of the red blood cells.

Many tumors release cells with distinctive antigens on their surfaces, and affinity - based techniques can pull these cells out of the blood sample relatively easily.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

Epitopes are displayed on the surface of circulating immune cells and are where T cells bind antigens to fuel the immune response.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

An animal's immune system detects foreign cells by scanning for proteins, called antigens, that stick out from the surface of each cell.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

Antigens are exposed on the surface of DCs in a protein complex along with major histocompatibility complex (MHC) proteins that mediate the recognition and activation of the appropriate T cell subtype.

Researchers already knew that there was a time lag of between 1 and 3 hours between the synthesis of Class II molecules within the APC and their appearance on the cell surface, combined with antigen.

Since then, evidence has emerged that the crucial human proteins are HLA antigens, proteins that appear on the surfaces of cells and vary from person to person.

To help the new organ withstand the assault from the recipient's natural defenses, doctors developed tissue type matching, a technique to determine if the chemistry of the donor's immune system, defined by antigens on the surface of cells, was similar to that of the recipient's.

They found that adding a hydrocinnamoyl ester on to the sugar stabilized the ligand and kept it close to the surface of the antigen - presenting cell, thereby enhancing its ability to dock with and stimulate human iNKT cells.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Two drug classes: adamantanes (FDA approved in 1966) and neuraminidase inhibitors (oseltamivir, FDA approved in 1999) represent two classes of drugs that target viral an ion channel and a cell surface antigen, respectively, hereby preventing or treating infection.

Dendritic cells constantly patrol the body, sampling bits of protein found on the surface of cells or viruses called antigens.

Antigens are flags on the surface of cells, and they trigger the immune response when the flags are foreign.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

For example, he's designing nanoparticles that bait specific immune system cells by displaying certain features on their surface; inside, the nanoparticles contain an antigen of a particular microbe.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

Each low - cost paper strip is impregnated with a matrix of dyes and antibodies that recognise antigens on the surface of red blood cells.

Hu14.18 K332A is a laboratory - produced antibody designed to activate the immune response against tumor cells by recognizing and binding to an antigen found on the surface of most neuroblastoma tumor cells.

D'Oro, U., Vacchio, M.S., Weissman, A.M. & Ashwell, J.D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.

When allergens enter the body, antigen presenting cells (immune cells that capture incoming substances and present them to other immune cells, initiating a cascade of immune responses) at body surfaces, capture and present them to immune cells, particularly T cells (in a similar manner as if the allergen was a foreign invading microbe).

The serologically unique cell surface antigen of Zajdela ascitic hepatoma is also its tumor - associated transplantation antigen.

HLA (human leukocyte antigen)- markers on the surface of a body's cell that identify the cell as one's own (as opposed to a foreign cell) and prevent the immune system from attacking itself.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Finally, cancer cells may naturally stop displaying antigens on their surface, as part of their strategy for evading an immune response.

The most potent of these, known as effector memory T cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of endothelial cells lining the donated organ's blood vessels.

Colin Barnstable, DPhil (M Club) Chair, Neural and Behavioral Sciences «Production of monocolonal antibodies to group A erythrocytes, HLA and other human call surface antigens — new tools for genetic analysis» Cell, 1978 2,020 citations, Web of Science, April 1, 2017

Their main function is to capture antigens from foreign invaders and present them to the cell surface of the T - cells — a kind of early warning of a breach of security.

When normal cells turn into tumour cells, some of the antigens on their surface change.

Monoclonal antibodies are a special type of protein designed to target antigens, or markers, located on the surface of cancer cells; antibodies locate antigens and recruit immune cells to attack.

This gradient of surface antigen expression was paralleled by a gradient in expression of pluripotency genes, with highest levels of genes like Oct - 4 found in the population of cells with the highest level of antigen expression.

The development of a standardized method to express large panels of P. falciparum cell surface and secreted proteins in their native conformation would enable comprehensive protein libraries to be systematically screened in parallel so that direct comparisons between antigens can be made in functional assays such as vaccine screening and immuno - epidemiology studies.

Flow cytometry allows researchers to quantify and isolate rare viable cell subsets from heterogenous populations in single - cell suspensions based on differential expression of surface antigens.

The pathways that connect expression of stem cell surface glycoconjugates such as the TRA -1-60 / GCTM - 2 antigen, receptors, and growth factors in human and even mouse ES cells with the transcriptional networks that regulate pluripotency remain unclear.

Levels of expression of pluripotency genes declined in parallel with the levels of stem cell surface antigens.

This loss of binding is often accompanied by a loss of ability to express (Barnwell et al. 1983; Handunetti et al. 1987; Gilks et al. 1990)-- or a major alteration in the level of expression of (David et al. 1983; Fandeur et al. 1995)-- the highly variable and clonally variant switching parasite antigens on the surface of the red cell known to be important for the maintenance of long - term chronic infections (Brown and Brown 1965).

The prominent cell surface expression of CD123 makes this antigen well suited for antibody - drug conjugate (ADC)- based therapeutic strategies.

The antigens are microscopic substances that live on the surface of your red blood cells.

Innate dendritic cells engulf and partially digest antigens (pathogens like our virus) and present a piece of that antigen on their cell surface, waving it like a flag for other immune cells to see.

Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q - real - time PCR; immune response by in - vitro antigen - specific T - cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis.

Found in the blood, lymph, and on the surfaces of B Cells as antigen receptors (antibody protein that is not secreted but is anchored to the B - cell membrane that help fight infection.)

Blood group antigens as glycoconjugates are found on the surface of cells lining the digestive tract in addition to the blood cells and are frequently the target of specific lectins resulting in agglutination reactions.

The surface of each red blood cell contains proteins called antigens.