Sentences with phrase «of cell surface molecules»

Characterization and functionality of cell surface molecules on human mesenchymal stem cells.

Not exact matches

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

«What we have described as globalization is remarkably close to Teilhard de Chardin's planetization, in which «[mankind, born on this planet and spread over its entire surface, come [s] gradually to form round its earthly matrix, a single, major, organic unity, enclosed upon itself.4 Thus the globalization of humankind could lead to the formation of a new kind of living entity — a social organism — on the same cosmic principle as that by which atoms join to form molecules, molecules join to form mega-molecules, mega-molecules unite to form living cells, and innumerable cells constitute an organism.

First the vitalization of matter, associated with the grouping of molecules; then the hominization of Life, associated with a super-grouping of cells; and finally the planetization of Mankind, associated with a closed grouping of people: Mankind, born on this planet and spread over its entire surface, coming gradually to form around its earthly matrix a single, major organic unity, enclosed upon itself; a single, hyper - complex, hyper - centrated, hyperconscious arch-molecule, co-extensive with the heavenly body on which it was born.

Inside the brain, prions presumably latch onto PrPC molecules on the surface of nerve cells and impose the prion conformation.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1 and Cxcl2, which attach to the surfaces of neutrophils and draw the immune cells into injured tissue.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

The mushroom - shaped protein specializes in infecting cells, first by binding a trio of sites on its head to three separate sugar molecules on the surface of targeted cells.

LFA - 1 molecules stud the surface of killer T cells.

Researchers studied the structure of proteins from one strain of the H7N9 virus that caused the outbreak and tested how strongly one of the proteins bound to molecules on the surfaces of bird and human cells.

MP1 interacts with lipids that are abnormally distributed on the surface of cancer cells, creating gaping holes that allow molecules crucial for cell function to leak out.

Endocannabinoids act on a group of cell - surface molecules called cannabinoid receptors that help to regulate appetite, mood and memory.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Bode believes these sugars, because they are indigestible, journey intact to the colon, where their structure mimics molecules on the surface of gut epithelial cells.

Some of the animals received normal T cells back, and others got cells deficient in a surface molecule that activates regulatory T cells.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

The microbes deploy FimH on the end of long, spaghettilike strands that extend from the cell body and latch onto sugar molecules on the surface of mucosal cells.

Ulijn's gel is composed of two simple synthetic peptide derivatives: (1) a component that binds to copies of itself with high directional preference, resulting in the spontaneous formation of nanoscale fibers when the molecules are dissolved in water, and (2) a surfactant - like molecule that associates with the fiber surface and presents simple, cell - compatible chemical groups.

The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.

The odorant receptor molecules sit on the surface of sensory nerve cells in our nose.

Researchers already knew that there was a time lag of between 1 and 3 hours between the synthesis of Class II molecules within the APC and their appearance on the cell surface, combined with antigen.

RAR molecules are abundant on the surface of cartilage cells, hence the positive targeted response of the drug.

Researchers knew that cells could ingest some molecules and break them down completely inside small vesicles called lysosomes, but none of the products was transported back to the surface of the cell.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

They looked specifically for genes coding the major histocompatibility complex (MHC)-- a molecule found on the surface of cells that acts as a crucial component of the immune systems of most vertebrates.

In earlier work, these investigators showed — as numerous others had done — that the messenger molecule, cyclic - di - GMP (c - di - GMP) promotes biofilm formation when such surfaces are present, said principal investigator Vincent T. Lee, Associate Professor, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park.

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

The researchers speculate that the act of reprogramming adult cells to pluripotency may induce the expression of cell - surface molecules the immune system has not seen since the animal (or person) was an early embryo.

The team, based at UCL, had already found that prostate cancer cells have more of the NAALADL2 molecule on their surface compared to cells from healthy tissue.

A pancreatic cancer vaccine could be made of whole pancreatic cancer cells, treated so they can't replicate, but modified to present certain molecules on the surface of those cells.

NASA researchers triggered international headlines in 1996 when they discovered, among other possible indicators of life, traces of polycyclic aromatic hydrocarbons (multiringed carbon molecules found in living cells) along surface fractures in ALH84001.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the stomach.

Their preliminary results identified two types of immune cells, CD4 + and CD8 + T cells, which become mobilized to attack various surface molecules on the TB bacterium.

The sodium channel lies on the surface of the nerve and muscle cells and is composed of a large molecule called the α - subunit, together with smaller β - subunit molecules.

Tucked into the internal surface of the cell's outer membrane, these versatile molecules coordinate cellular responses to a multitude of signals that impinge from without

They may also induce the production of antibodies that bind to molecules on the surface of cancer cells.

Hans Røy, a geomicrobiologist at Aarhus University, found that each cell uses about one oxygen molecule per second — roughly one hundred - thousandth the metabolic rate of typical surface bacteria.

«We demonstrated some time ago that a molecule called AAQ is capable of causing nerve cells to become light - sensitive, because it modifies the behavior of ion channels in their surface membranes,» Trauner says.

Chemists in California have identified and synthesised a complex sugar molecule which lies on the surface of white blood cells, and through which the cells «recognise» those blood vessels that lie near injured tissue.

If you imagine the female egg cell (and later, the fertilized egg) as a spherical planet with its own intrinsic biological geography, then certain characteristics of that cell — the location of protein molecules or RNA messages or biochemical traits like pH or even the internal connective structures called microtubules — will be more prominent in certain regions, like one hemisphere as opposed to the other, or near the surface rather than near the core.

On the surface of our numerous star - shaped brain cells called astrocytes, they have found the molecule LRP4 is important in ensuring healthy levels of a brain chemical that enables learning and memory, said Dr. Lin Mei, chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Augusta University and Georgia Research Alliance Eminent Scholar in Neuroscience.

This could be done by attaching molecules to the surface of the bots that bind to specific receptors on the outside of certain types of cell.

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.