Sentences with phrase «of cell targeting»

To develop a more general strategy of cell targeting, the researchers coupled nanoparticles to antibodies that target other highly expressed proteins in neurons.

«The AAV - DJ / 8 subtype combines multiple serotypes, giving us a broader range of cell targets for the delivery of our CRISPR / Cas9 system,» Dr. Hu said.

Not exact matches

The start - up's premiere product, the Thin Ice vest, uses cold therapy to target areas of the body with high concentrations of thermoreceptors, which are nerve cells that are able to detect the presence of hot or cold temperatures.

Instead of being injected into the bloodstream and exposed to the rest of the body's tissue — with all the unpleasant side effects, as is the case with chemotherapy — these agents only target cancer cells.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

So research teams began souping up various types of immune cells and even targeting them to specific protein markers on tumors.

«The holy grail is to target a piece of the virus by antibody or t cell,» Tom Evans, the CEO of a company called Vaccitech that is working on a universal vaccine they hope can be used to treat all strains of influenza A, told National Geographic.

Most of the action is coordinated by white blood cells, which direct the lines of attack like football coaches, churning out antibodies that target the opponent for destruction.

One recent example: Stemcentrx, which rode an unproven approach targeting cancer stem cells to a summertime financing round of nearly $ 250 million and a $ 5 billion valuation, the most for a venture - backed drug maker and second to Theranos in health care.

Unlike some of the promising treatments that have failed in 2017 that deal with the so - called «amyloid hypothesis» (the treatments target amyloid beta deposits in the brain that accumulate in people with Alzheimer's disease), approaches that try to prevent nerve cells from dying wouldn't have any impact on that buildup.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.

Now, DuPont's research labs, which produced discoveries such as nylon, rayon, Teflon, and solar cells, is the target of persistent activist attacks.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

Cambridge, MA — December 21, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it closed a $ 30 million Series C financing.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

The Japanese government has set a target price of ¥ 2.2 million — around US $ 18,000 — for fuel - cell vehicles by 2025.

What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investCell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investcell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

A 17 - year - old California girl won $ 100,000 in a national science competition for her creation of a nanoparticle that can target and kill cancer cells.

Eilersen has announced it is releasing a new series of digital load cells in a hygienic (aseptic) design for dynamic and process weighing, filling, packaging, and general weighing applications targeted primarily at food and pharmaceutical customers.

Schumer helped author the legislation that established the registry but he said technology has gotten ahead of the law and now cell phones have become the target.

However, these same inflammatory responses can become part of a disease if they mistakenly target the body's own cells, such as occurs in the case of autoimmune conditions like Crohn's disease.

«If we want to treat the greatest number of diseases, we need to figure out how to get these molecules inside the cells of patients — not just increasing the number of target cells but also hitting tissues other than the liver,» says Anderson, who co-founded a company called CRISPR Therapeutics to pursue those goals.

To discover these targets, the team determined when and where each gene is turned on or off in the cells and tissues of H. contortus to reveal new insights into the worm's lifecycle.

These cells protect many types of tissues from infection, but they can also promote chronic inflammatory conditions like Crohn's disease, which specifically targets the intestinal tract.

«Now that we have a more complete understanding of this stability, we can better tailor the nanoparticle morphologies and in turn properties, to applications from biolabeling of individual cells and targeted drug delivery to catalytic reactions, thereby creating more efficient and sustainable production processes.»

In an attempt to answer this question, the researchers undertook a targeted manipulation of leukemia cell DNA in the lab.

By targeting the affected cells instead of the virus, the approach could also cut the chances of the virus becoming resistant to the therapy, researchers say.

So, the researchers — headed by Professor of Physics and Biological Sciences Shane Hutson and Associate Professor of Cell and Developmental Biology Andrea Page - McCaw — targeted cells on the back of fruit fly pupae that expressed a protein that fluoresces in the presence of calcium ions.

To target liposomes to certain tissues or cells, such as tumour cells, a specific binder of a unique protein (an antigen) on the targeted cell, known as a monoclonal antibody, must be linked to the liposome surface.

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

«xIAP has other roles in the cell, such as regulation of cell death, so it is a tricky target for treating inflammatory diseases.

A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

«Now that we've confirmed the human relevance of our findings, our future goal is to better understand the roles of the different cell types in psychiatric and neurological disorders, and to determine if targeting these cells can actually help treat seizures,» concluded Paz.

These results significantly advance understanding of how cancer cells are made to move during metastasis and may provide more precise targets for drugs to stop cancer metastasis in patients where there are oncogenic mutations.

«Because BX795 targets a common pathway that many viruses use to replicate inside the cell, it could be a new kind of broad - spectrum antiviral that might be used to treat other viral infections, including HSV - 2, which primarily affects the genitals, and HIV, although we have not yet tested it on viruses other than HSV - 1.»

Different CARs determine what types of tumors T cells target.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.

Single - cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

When a target gene is unmethylated, the reporter is also unmethylated, triggering expression of a glowing protein that illuminates the cell.

Even before treatment, cancer patients in the study had a small number of infection - and tumor - fighting T cells that target these unusual proteins, the researchers found.

These new, non-invasive tools — representing significant advances related to positron emission tomography (PET), 3 - D microscopy and the use of magnetic fields and nanoparticles to remotely control targeted cells...

The new technology, described in the journal Molecular Cell, offers a new way to seek drug targets for many diseases, not just Parkinson's, says Timothy Lu, an MIT associate professor of electrical engineering and computer science and of biological engineering.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

Since it is proteins that do the reprogramming, rather than the genes that make them, the researchers reasoned that they simply needed to get enough of the proteins into the target cells.

In fact, combining cell activation and the overproduction of the neuropeptide, which is released when the cell is activated, caused the flies to attack targets they normally would not.

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.

Based on the evolutionary idea that targeted epigenetic stochasticity can improve adaptation, these observations could explain how cancer cells are good at evading chemotherapy treatments and spreading from one part of the body to another, he adds.

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.