Sentences with phrase «of cell transformation»

However, the information acquired from regular two - dimensional culturing might not be directly applied to the process of cell transformation, which is typically assayed in three - dimensional conditions.

We have shown that telomere instability due to excessive shortening is the main driving force of chromosome aberrations during the early stages of cell transformation.

Not exact matches

Thus, the transition from instinct to reason results in the radical transformation of the animal into man; matter as it evolves toward the cell becomes radically transformed into living matter; and vegetative life becomes qualitatively changed into conscious life.

And let's remember that evolution, while it's a theory, is a theory about the beginning and the transformation of life based on things we have observed, namely that cells change and mutate and that those mutations can produce cells that are unique and new, and that it would follow that it's possible for molecules to form into single - celled organisms which mutate and combine into multi-cellular organisms which mutate, adapt, and grow over time into new forms of life.

Because these other skin cell types showed no signs of expansion or transformation, our analysis highlights pigment - producing cells as the originators of melanoma.»

Adenovirus 36 has been found to encourage the transformation of adult stem cells in fatty tissue into fat cells as discussed on the daily Scientific American podcast 60 - Second Science on August 20th.

The team tested the technique on cells in culture that mimic the transformation of unspecialised white blood cells into full immune cells.

This transformation has put new life into the development of both dedicated natural gas vehicles and fuel cell cars.

The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»

Although Herrera's group has investigated the versatility of pancreatic cells in mice, several observations in diabetic patients suggest that the human pancreas is capable of transformation too.

By tweaking different fly genes and counting how many neuron types were produced as the flies matured, the team identified a network of five genes that work together like coordinated control switches to guide the precursor cells» transformation to mature neurons.

«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.

Even distantly related bacteria can swap genes with one another using a variety of techniques, from direct cell - to - cell transfer, called conjugation, to transformation, in which a bacterium releases snippets of DNA that other bacteria pick up and use.

In the experiment, Jiang's team fabricated a broadband active frequency - selective surface with a stretching transformation pattern on a printed circuit board, and soldered the resistors and varactors between each of the two unit patterned cells.

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol — mediated transformation.

A protein on the cell surface of P. syringae binds water in a way that mimics the structure of an ice crystal, and this helps start the transformation of cold water into ice.

Melanoma is a malignant tumor resulting from the transformation of melanocytes, the cells that undertake to synthesize melanin, which protects us from the negative effects of solar radiation.

This process is called metastasis and requires a whole network of genes to regulate the transformation of cell shape and mobilization.

«The spectrum of tissues at risk for transformation when harboring a p53 mutation include many of those that we would like to target for repair with regenerative medicine using human pluripotent stem cells,» said Eggan.

As a result, they gained new understanding of how a substance known as transforming growth factor triggers cell transformations.

Normally, the genetic switches that control the transformation of an embryo into a larva or a larva into a polyp are switched on in an order that is irreversible, «but Turritopsis cells can hit the rewind button,» Piraino explained.

As a newly hatched larva, Nyuki listens while her mentor, Dvorah («bee» in Hebrew), gently explains her impending transformation: A group of cells in her larval body will turn active, consume her from the inside out, and rebuild her as a mature bee during her imprisonment in the cocoon.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

They are hypothesized to be the cells that undergo cancerous transformation and cause Merkel cell carcinoma, an aggressive form of skin cancer with no effective treatment.

A paper published in The Plant Cell reports a breakthrough in transformation technology that greatly expands the range of cultivars and species that can be transformed.

Thus, the sustained activation which is necessary for a transformation of cells into cancer cells is lacking.

Using a variety of methods to induce somatic cells to become iPSCs, the researchers first found that in the early stages of reprogramming, the transformation was consistently accompanied by an increase in ROS generation.

Their activation of innate immune signaling caused epigenetic changes that were absolutely necessary for the transformation of somatic cells into iPSCs,» explained Cooke, who holds the Joseph C. «Rusty» Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research.

In a new Cell Reports paper, a team led by John P. Cooke, M.D., Ph.D., of the Houston Methodist Research Institute, has identified and characterized a biological factor critical to the transformation of adult somatic cells (cells that are not sperm or egg cells) into stem cells.

In addition, mature CD4 + T cells appear to be resistant to malignant transformation [54], thus mitigating the potential concerns of off - target disruption.

Subsequent experiments carried out at the Laboratory of Cell Biology in Rome by Luigi Aloe and one of us (Levi - Montalcini) demonstrated that this remarkable transformation can also take place in the intact animal: repeated injections of NGF into rat fetuses, continued for two to three weeks after birth, resulted in the differentiation of chromaffin cells into sympathetic neurons in the core of the adrenal gland!

Cancer arises from the transformation of normal cells into tumour cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant tumour.

The presence of the protein β1 - integrin was shown to help promote the transformation of those undifferentiated stem cells into muscle after the tissue has degraded, and improve regenerated muscle fiber growth as much as 50 percent.

However, when Jurkat cells are infected with HIV - 1 the proportion of cells that become latently infected vs. productively infected is small, suggesting that transformation does not result in the indiscriminate methylation and repression of HIV - 1.

However, because J - Lat cells divide autonomously and possess other aberrations associated with cellular transformation, cytosine methylation was analyzed in a recently developed primary cell model of latency [43].

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

Not only did the team's results point to the power of chemical reprogramming to generate a complete transformation, they also revealed that this type of regenerative therapy could use the patient's own cells to regenerate the cells lost to disease.

Interestingly, suppression of Dicer activities is reported to result in promotion of epithelial - mesenchymal transistion and metastatic transformation of cancer cells.

Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three - dimensional culture.

The research offers new hope in the fight against many neurological conditions because scientists expect that such a transformation — or reprogramming — of cells may lead to better models for testing drugs for devastating neurodegenerative conditions such as Alzheimer's disease.

We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host - cell transformation, and a Theileria - specific protein domain [frequently associated in Theileria (FAINT)-RSB- present in a large number of secreted proteins.

In the October issue of Cell Stem Cell, Marius Wernig, MD, PhD, a NYSCF — Robertson Investigator at Stanford University, reported on the successful transformation of mature liver cells from laboratory mice into functioning neurons.

(2015) TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.

Jin also believes that the novel X-ray imaging technique will facilitate the studies of other technologically important solid - state transformations and help to improve processes such as preparation of inorganic ceramics and thin - film solar cells.

STAT5 is also activated by the oncogenic breakpoint cluster region (BCR)-- ABL tyrosine kinase and contributes to the transformation of leukemia cells (45).

Since leukemias and lymphomas originate from the malignant transformation of individual lymphoid cells, all leukemias and lymphomas generally share one or more cell - specific or «clonal» antigen receptor gene rearrangements.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.