It actively engages biologists working on distinct molecular mechanisms
of cells migration and helps them interact beyond the boundaries of independent laboratories.
A study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation
of cell migration.
The team from the Massachusetts General Hospital plans to use the microfluidic devices in synergy with some more sophisticated molecular biology tools and identify the control factors
of cell migration speed.
A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement
of cell migration speed before and applied the new tool to study the variations of migration speed in population of cancer cells.
Microfluidic tools for precision measurements
of cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations.
«The more insights we get into the mechanisms
of cell migration, the more effectively and focused we will be able to intervene in certain pathological processes,» first author Dr. Katrin Martin comments.
Researchers from the Department of Biomedicine at the University of Basel discovered novel mechanisms
of cell migration by observing cells moving on lines of connective tissue.
The scientists describe novel concepts
of cell migration, which could help to find new targets and approaches to fight cancer metastasis and inflammation.
This direct link between Exocyst and WRC complexes provides a novel mechanistic insight into the spatio - temporal regulation
of cell migration.
Arrow indicates the direction
of cell migration.
Inhibition
of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].
Open access microfluidic device for the study
of cell migration during chemotaxis.
Our insight will substantially enhance our understanding of dynamic cell shape regulation for instance in the context
of cell migration as in cancer metastasis or during morphogenesis.
The broad objective of our research is to understand how epithelial cells interact with their microenvironment during migration, focusing on the mechanism
of cell migration and the role of actin cytoskeleton in this process.
Not exact matches
Additionally, Belly Belly shared a baby's brain is extremely vulnerable to stress because
cells are still moving where they need to be (
migration) for the first year
of life.
In the article, Dr. Margot Sunderland, author
of the best - selling book What Every Parent Needs To Know, stated that leaving a child in a state
of distress for a prolonged period without offering comfort affects them on a cellular level, specifically the «
migration»
of their
cells as they get to where they need to be.
at The Scripps Research Institute and the Burnham Institute, and also at the National Institutes
of Health, where her studies spanned signal transduction,
cell migration, and neuronal development.
The researchers also report that saliva increased DENV infection
of immune
cells in the skin and enhanced immune
cell migration to neighboring lymph nodes, which could promote the spread
of disease throughout the body.
But when their functioning is altered, as the UCL researchers observed in tumor
cells, the mitochondria can promote
cell migration, thus leading to the formation
of metastasis.
Groups
of red and green labelled embryonic
cells in a zebrafish during their first
migration in gastrulation.
The scientists hope their findings on
cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy
of cancer.
The phase
of gastrulation, in which the germ layers form through invagination
of the outermost
cell layer, is the first great
cell migration phase in the development
of vertebrates.
Much
of the research into tumor
cell migration, however, has represented the tissue as a solid gel.
Adding two blood - borne proteins associated with cancer
cell migration increases the predictive ability
of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University
of Texas MD Anderson Cancer Center reports in the Journal
of the National Cancer Institute.
Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication
of neuronal stem
cells that have the potential to become multiple different kinds
of cells, including neurons — and
migration — the movement
of neurons to specific locations in the brain during development.
This study, published in the journal Microarrays, shows that lack
of SOST in the bone microenvironment promotes the expression
of many genes associated with
cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
To see if the same chain
of events happens in rheumatoid arthritis, Smith's team tested whether various kinds
of fibroblasts would spur T
cell migration in test tubes.
The inside back cover image
of the Nov. 20, 2017 issue
of Advanced Materials illustrates how ion
migration in a hybrid perovskite crystal affects solar
cell performance in different areas
of the crystal.
The T
cell migration halted again when the team added a chemical that blocks the IGF - 1 receptor, the authors report 23 August in the Journal
of Immunology.
In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University
of Tokyo, report that the L1
Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon
migration.
Hyder further tested luteolin and its effects on subduing the
migration of triple - negative breast cancer
cells throughout the body.
This analysis, done on separate samples from the same patient, revealed that many
of the affected genes confer advantages to cancer
cells by, for example, enhancing
cell migration or resistance to chemotherapy.
«Blocking the
migration of cancer
cells to destroy them.»
Like a free pass, its presence on the surface
of lymphoma
cells facilitates their
migration through the vessel walls between adjacent endothelial
cells.
New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and
migration of lung - cancer
cells, and the induction
of programmed
cell death, or apoptosis, in those
cells.
The research demonstrated that following injury, there is increased
migration of inflammatory
cells from blood to the liver, increasing IFNL3 secretion and liver damage.
The team also found five genes in domestic cats that influence the
migration of neural crest
cells, stem
cells in the developing embryo that affect everything from skull shape to coat color.
While much remains to be learned about chemotaxis and
cell migration, the authors hope that future races will be a fun - spirited approach to continue investigating
cell motility and chemotaxis on a large - scale, as well as to provide further insight into relevant areas
of research.
EMT is important for
cell migration and invasion — two characteristic
of metastatic cancer
cells — strongly suggesting that the link between lncRNAs and EMT contributes to the metastatic progression
of ovarian cancer.
Researchers at the Medical University
of South Carolina (MUSC) have identified one mechanism that regulates signaling events leading to
cell migration and metastasis.
The ability
of cancer
cells to change position within body tissues through
cell migration and invasion represents the biggest threat
of cancer to human health.
Named after the enigmatic sphinx, this
cell signal is important in many activities
of living
cells, from
migration to proliferation.
To test this idea, they experimentally reduced the expression
of the DNM30S lncRNA, which resulted in reduced ovarian cancer
cell migration and invasion.
«In normal conditions, the microenvironment is able to control the proliferation, differentiation and
migration of the hematopoietic stem
cell.
Traditionally, scientists have tried to approach the problem
of cancer
migration by targeting molecules inside cancer
cells, but finding an appropriate target has proved challenging.
«New mechanobiology technique to stop cancer
cell migration: Researchers have synthesized a molecule that targets the membranes
of cervical cancer
cells to block their
migration.»
They are associated with the
cell cytoskeleton — a complex network
of interlinking filaments inside the
cell that is necessary for
cell migration — making them viable targets for inhibiting
migration.
By decreasing the expression
of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates
cell migration and metastasis.
More importantly, the fibronectin part
of the complex is expressed during a
cell's transition to cancer and plays a role in
cell growth,
migration and differentiation.
Researchers at the Okinawa Institute
of Science and Technology Graduate university (OIST) have developed a novel technique that stops cervical cancer
cell migration.