Sentences with phrase «of cells sequenced»

The depth of insight is limited only by the numbers of cells sequenced and cheaper sequencing will enable us to see far back to the early stages of life, and study inter-individual variation in development.

Not exact matches

By collecting sequencing information about cells in the gut, for example, Kallyope can better figure out how they're connected to neurons in the brain in a series of circuits.

That's attached to the progress of sequencing technology, the ability to edit cells, and other gene editing approaches have been transformative in the immunotherapy world in recent years.

Researcher Aviv Regev's «lab has gone from looking at 18 cells at a time to sequencing RNA from hundreds of thousands.»

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

From which it follows, ultimately, that the self must be regarded as a series of momentary selves the unity of each of which can only be regarded as the unity of a complex set of what I will refer to as «interrelated event - cells,» while the unity of the more general sense of «person» or «self» can only be regarded as the unity of a sequence or succession.

People of every nation, color, language, belief, and condition are now known to possess in their body cells trait factors drawn by an inconceivably complex sequence of intercombinations from a common «gene pool.»

The evolutionary sequence from protons, molecules, cells, plants and animals to people would be interpreted as an increase in complexity of experience and degree of self - determination.

@Chad: I. Mutations in DNA sequences generally occur through one of two processes: A. Environmental factors: DNA damage from environmental agents such as ultraviolet light (sunshine), nuclear radiation or certain chemicals B. Mistakes that occur when a cell copies its DNA in preparation for cell division.

«Cells have not selected against dynamic oscillations in their control circuits, but have made use of them to organize the staggering complexity of cellular dynamics into a well - ordered rhythmic sequence of biochemical processes.

I love biology, every pain staking detail of DNA - one mess up in an amino acid sequence and you get sickle - cell anima, or the proteins don't function correctly.

The existing patterns of physical feeling in my brain cells have to be deflected repeatedly by fresh novelty — now this way, now that way, in a tedious sequence of trial - and - error, before these tiny bodily societies learn the new patterns which enable them to respond to my aims to type.

Each of these cells, like the psyche, is a sequence of actual occasions of experience, each with its own reality and measure of autonomy.

«This agreement is wonderful,» says Jay Shendure of the University of Washington, who has sequenced 10 strains of the cells.

To determine how the cells switch from one type to another, they took three human uterine carcinosarcoma samples and sequenced the genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.

While all cells in a specific organism share the identical DNA sequence, only a fraction of those genes are activated in a given cell type.

Lacks» family was never asked for permission to harvest her cells, an ethical violation made worse in March when German researchers published the sequence of the HeLa genome without asking.

These modifications represent a layer of information that can be passed from a parent cell to a daughter cell but is not encoded in the DNA sequence.

«If we could use gene editing to remove the sequences in an embryo that cause sickle cell disease or cystic fibrosis, I would say not only that we may do so, but in the case of such severe diseases, we have a moral obligation to do so.»

The team designed DNA circuits that simultaneously test for 24 distinct regions of viral RNA — more than would have been possible using only naturally occurring DNA sequences (Cell, doi.org/wn4).

«It's difficult to make contrived samples behave like actual cell - free nucleic acids, so that's been quite a challenge,» says Kelli Bramlett, director of R&D in clinical sequencing and oncology at Thermo Fisher Scientific in Waltham, Massachusetts.

But to coax them down a specific path in the lab requires recreating the precise sequence and timing of environmental cues in the womb — the signals from proteins and hormones that tell cells what kind of tissue to become.

«We couldn't have figured out what was happening without the expertise of our collaborators at U.C. Davis, who determined the genetic sequence of every single cell marker on the cells in the lymph nodes,» says Miller.

Zhang's group is moving beyond bulk sequencing of tumor samples and is now conducting genomics on single cells.

«However, because SIF - seq only requires DNA sequence from a mammal and can be used in a variety of cell types, it should be possible to compare the neuronal enhancers present in a large genomic region from human to the neuronal enhancers present in the orthologous chimpanzee region.

The kit also preserves the single - nucleotide variants (SNVs) and SNV frequencies across different sequencing technologies and allows the amplification of cell - free DNA to levels that permit sequencing.

The man responsible for one of the original sequences of the human genome as well as the team that brought you the first living cell running on human - made DNA now hopes to harness algae to make everything humanity needs.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

Umen focused on the «mating locus» (MT)-- the genetic sequence behind the making of sex cells.

Bingwei Lu, a neuroscientist at Stanford University in California, has shown that a microRNA sequence which suppresses certain genes is linked to the death of brain cells in fruit flies.

Now scientists think they have cracked the code: Insect nerve cells appear to fire in a sequence unique to each smell, says a report in the 14 November issue of Nature.

It's well established, of course, that environmental effects like radiation, which alter the genetic sequences in a sex cell's DNA, can leave a mark on subsequent generations.

Slight modifications in their genome sequences play a crucial role in the conversion of pluripotent stem cells into various differentiated cell types.

«We were looking at the amino acid sequences of T cell receptors when Tomer asked what the corresponding epitope was for a particular receptor,» Thomas said.

Even after the principles of epigenetics came to light, it was believed that methylation marks and other epigenetic changes to a parent's DNA were lost during the process of cell division that generates eggs and sperm and that only the gene sequence remained.

To start, she used a cotton swab to get a sample of cells from her cheek, boiled them in a test tube in her kitchen to free the DNA, then added primers, nucleic acids that mark the part of the sequence.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

All of them were found in the synthetic cell when it was sequenced.

By delivering this version of Cas9 along with the guide RNA strand into single cells, the researchers can target one genetic sequence per cell.

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

CRISPR is a combination of an enzyme that can cut a selected DNA sequence and a «guide RNA» that takes the enzyme exactly where you want to make the cut — in this case, at the sickle cell mutation.

Scientists investigating the earliest stages of cancer development used an exquisitely sensitive sequencing method capable of detecting DNA mutations present in as few as 1.6 per cent of blood cells, to analyse 15 locations in the genome, which are known to be altered in leukemia.

There, some of the added DNA was swapped with the matching target sequences in the cells» genomes.

Through a variety of «high tech» approaches, including the isolation of monoclonal antibodies from single B cells and ultra-deep sequencing of shifting viral populations over more than three years of infection, the researchers studied one woman who developed potent broadly neutralizing antibodies.

Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.

Bar coding typically involves sequencing a few short segments of animal DNA from the mitochondria, the mini-organs that produce energy within every cell.

12 Telomeres, sequences of DNA at the tips of chromosomes, get shorter every time a cell divides; when they get too short, the cell dies.

A major part of the project was identifying sequences that cells copy, or transcribe, into RNA molecules.