Sentences with phrase «of cellular behaviors»

«Now I see noise as a lens through which to look at all kinds of cellular behaviors.»

«Noise can be both an obstacle for some types of cellular behaviors as well as a useful feature for others,» Elowitz said.

Importantly, Zika virus also follows the same pattern of cellular behavior of repressing the cell's translation and stress response while promoting its own protein translation.

Not exact matches

The model has allowed scientists to get a much closer look into the cellular interactions and biological behavior of M. genitalium, a very simple bacterium that is sexually transmitted between primates and can cause itching, burning or discharge.

I needed to get into the nitty - gritty details of what drives behavior on a cellular or even molecular level.

So in 1974, he headed south to Tulane University in New Orleans, Louisiana, for graduate training in physiological psychology: the study of how the brain influences behavior at the neurochemical and cellular levels.

And once I got into brain biology, it became clear you needed to study the brain on the cellular level, and once you began to understand aspects of behavior in the cellular level, you wanted to understand the molecular level.

The changes in cellular structure and behavior were the opposite of what Xu - Friedman team's saw in a previous study that placed mice in a consistently noisy environment.

«In this way, modern supercomputers allow millions of small timesteps of atomic motions to be simulated, getting us to examine the protein but also cellular membrane behavior on the microsecond timescale.»

Knowledge of the cellular and molecular details of these adaptations could lead to new treatments for the compulsive behaviors that underlie addiction

This finding is an important step towards a better understanding of the cellular and molecular underpinnings of addictive behavior, paving the way for the development of effective therapeutics.

The living organism is often too complex to identify the specific causes of a particular cellular behavior.

«Our findings fit with the growing appreciation of the importance of a cell's structural and biochemical surroundings in influencing cellular behavior.

However, due to technological limitations, previous genetic studies largely focused on mixed populations of cells, obscuring critical nuances in cellular behavior.

A multicellular marine animal without organs, Trichoplax's feeding behavior may include cellular coordination, resulting in external food digestion, according to a study published September 2, 2015 in the open - access journal PLOS ONE by Carolyn Smith and colleagues from the National Institute of Health in Bethesda, MD..

Their observation provides a better understanding of cytoskeletal self - organization in general, which may in turn lead to better drug design and new materials that can mimic cellular behaviors.

A team of researchers led by Charles D. Nichols, PhD, Associate Professor of Pharmacology at LSU Health Sciences Center New Orleans, has successfully translated a new technology to better study behaviors and cellular function to fruit flies.

Systems biology provides better methods of drug discovery: research teams can measure changes in genetic activity, protein levels and cellular behavior of the immune system in response to a potential vaccine.

«It's cellular makeup, it's child behaviors and child attributes, it's family behaviors within communities and environments within state and national level policies,» says Kristen Harrison, founder of the university's Synergistic Theory and Research on Obesity and Nutrition Group (STRONG) Kids project.

Manipulating biological processes with minimal interference, from the cellular level to the behavior of whole organisms, is a burgeoning scientific effort to better understand how living things work and to develop more effective treatments for a range of medical disorders.

Due to these crucial roles in regulating normal cellular behavior, redox status has been recognized as a key area of biological research in various diseases, including cancer.

Though much is known about the cellular and molecular components of the clock, the connections that link clock cells to overt behaviors, such as rest / activity behavior, have not been identified.

He also envisions that this kind of nanomechanical phenotyping should allow for the development of predictive models for cellular behavior for any kind of cell.

More broadly, he said, «These findings are part of an emerging theme that there is a whole spectrum of diseases that includes ALS, and some forms of dementia and myopathy, that are caused by disturbance in the behavior of these structures that perturbs cellular organization.»

Researchers are building a substantial understanding of the biophysical, molecular, and cellular interactions of neurons, but directly relating those interactions to outward behaviors is an ongoing challenge in the field.

Scientists injected fluorescent molecules into about 150 mouse brain structures and used a high - resolution microscope to document the molecules as they moved through the brain's «cellular highways,» which need to be in tip - top shape for different parts of the brain to communicate and coordinate behaviors.

Proteins perform virtually every task within cells, and accordingly the composition of the ensemble of proteins present at a given time generally determines cellular behavior.

Previous work by Fredberg and colleagues had documented the importance of collective cellular behavior in asthma, showing that cells comprising epithelial tissues — which line the surfaces of all organs throughout the body — can unjam and flow like a fluid, or jam and freeze like a solid.

Dr. Chartoff's Neurobiology of Motivated Behavior Laboratory, founded in 2009, investigates the molecular, biochemical, and cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.

Although some of the key molecular components involved in the formation of cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.

These results complement cellular and physiological data and show that dopamine at encoding promotes the prioritization of events in memory, with implications for understanding the role of memory in adaptive behavior.

When mutations do arise and cancer ensues, traditional chemotherapies have taken advantage of the universally - dividing behavior of cancer cells, attacking the cellular machinery necessary for division.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

Grillner's experimental and theoretical analysis of motor coordination in the lamprey has served as a standard for other attempts to describe the circuits that encode vertebrate behaviors in precise cellular and anatomical terms.

Royet will present his latest data dissecting the cellular and molecular mechanisms by which one single microbiota - derived compound, peptidoglycan, influences the behavior, the physiology, and the homeostasis of its infected host.

Further, there is evidence to suggest that AGEs produce raised levels of chronic inflammation by altering cellular behavior through the receptor for AGEs, RAGE.

ATF2 is a protein that can regulate a vast array of gene expression and therefore can contribute to many cellular behaviors and processes.

By comparing the regulatory networks of pathologic conditions, I expect to gain new insights into the central question: how do regulatory networks instruct cellular behavior under diseased condition and can we discover drugs that can alter these regulatory networks.

«Behavior represents the ultimate output of brain functions and can be used to assess the importance of specific cellular or molecular mechanisms, as well as for the evaluation of therapeutic interventions.»

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy.

«In neuroscience, there is a huge black box between genetic information and behavior,» said Krogan, who is also the director of the Quantitative Biosciences Institute and a professor of cellular and molecular pharmacology at the University of California, San Francisco (UCSF).

«Our ongoing project aims to elucidate how cells recognize temperature or cellular events caused by the temperature changes and control the expression of DESAT1 to adapt the cellular processes and behaviors,» Umeda said.

In my lab, we explore the molecular, cellular, and behavioral mechanisms through which two types of molecules, sex steroids and neuropeptides in the vasopressin / oxytocin family, act within those circuits to influence social behaviors associated with reproduction.

«Vertical integration of gene function» describes how gene expression initiates a series of biochemical, cellular, and physiological changes that ultimately culminate in an observable behavior.

The level of detail gained in this work was, and still is, unique in that it allows the observation of changes in behavior caused by changing occurring at the cellular and network level.

Automated method detects activity of neurons during specific behaviors, brainwide, at cellular resolution...

The cellular mechanisms underlying this bursting behavior have been studied in vitro, using either acute slices of the adult hypothalamus, or organotypic cultures of neonatal hypothalamic tissue.

The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning cellular energy pathways in the brains of people suffering from this disease.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).