Sentences with phrase «of cellular changes»

But pioneering studies showed that molecular bric - a-brac could be added to DNA in adulthood, setting off a cascade of cellular changes resulting in cancer.

Not exact matches

The biggest game - changing tool for 2011 is a new generation of fast wireless cellular standards known as 4G.

Flamingos change color based on their diet and how can we truly understand all of the dynamics at a cellular level to cause a mutation in a bacterium?

Freezing changes the cellular structure of many foods and thus many foods that are frozen to perfection wind up a different texture when they are thawed.

We are now beginning to understand some facets of human emotionality, decision - making, morality, trauma and the drive for political power down to the cellular level, by observing changes in neurochemistry, neural pathways, and neuro - anatomical transformations in the brain.

«The courts would be overwhelmed with cases in which people say I have been exposed to a harmful chemical and, therefore, I have cellular changes and I'm entitled to medical monitoring,» said Birnbaum, a New York City attorney often referred to as the «Queen of Torts» for her work in mass - tort litigation involving lawsuits filed against corporations.

What's more, the important part of this research is that one type of fat can change to another, and that cold triggers cellular mechanisms that lead to the formation of more brown fat.

The cellular changes in the workers reflected toxicity in the bone marrow, a sign of leukemia, she said.

Their work also revealed how tensegrity - based changes in molecular shape can drive the motion of cellular parts.

«But we know that the expression of these factors is inducing changes in the epigenome, and those are leading to benefits at the cellular and organismal level.»

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

It is critical for physicians to monitor these secondary tissue damages, as they are frequently the origin of significant long - term effects, including brain damage, cognitive deficits, psychosocial / behavioral / emotional changes, bodily damage and biochemical changes at the cellular level.

When exposed to cold, clusters of cells within the body's white fat become beige — a color change that reflects the creation of more energy - producing mitochondria, cellular components that enable cells to burn calories and give off heat.

HIF - 1 senses reduced oxygen levels and triggers many changes in cellular function, including a changed metabolism and sending signals for the formation of new blood vessels.

This opens up the possibility for the production and use of sentinel circuits, which produce other bioactive compounds in response to environmental or cellular changes, to target a range of diseases including cancer.»

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

He hypothesized that changes can occur at the cellular level within the brain and may be related to myelination, the process of building the protective sheath around the nerves.

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

Future work will focus on the underlying mechanisms involved in developmental changes in colouration, including the role of visual feedback and cellular processes.

The changes in cellular structure and behavior were the opposite of what Xu - Friedman team's saw in a previous study that placed mice in a consistently noisy environment.

In all, 77 of the 300 had lymphoma, leukemia, or cellular changes that were predictive of those diseases.

For example, such an approach might eventually form the basis for treating the most common cause of infertility — the failure of the embryo to successfully implant — or for affecting the cellular changes that lead to the development of cancer.

«Our findings indicate that metabolites alone appear to be able drive many of the key changes in cellular function and differentiation,» Ruohola - Baker said.

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

«We have successfully used cinnamon to reverse biochemical, cellular and anatomical changes that occur in the brains of mice with poor learning,» Pahan said.

Polansky and Javaherian (both from The Center for the Biology of Chronic Diseasein Valley Cottage, NY) explain the molecular, cellular and clinical changes that result from a latent infection with the CMV and the consequent decrease in longevity.

But these molecules have been difficult to study, and Tavazoie's team wanted to know if changes in the amount of tRNAs can affect cellular function.

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

«We found that mitochondria communicate changes in cellular organization to initiate a specific metabolic reconfiguration that supports primitive hMSC properties,» said Dr. Teng Ma, senior author of the STEM CELLS study..

Gartner's group plans to use the technique to investigate what cellular or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize, invading other parts of the body and threatening the life of the patient.

Epigenetics: The Ultimate Mystery of Inheritance By Richard C. Francis (W. W. Norton) Researchers once considered DNA to be the exclusive carrier of heredity, but recently they have discovered that certain life experiences — smoking before puberty, say, or a high - stress pregnancy — can trigger cellular changes that get passed along to future generations.

Like this, the researchers from Jena, Berlin and Duisburg - Essen were able to conclude that lifespan extension in rodents can be attributed to changes in their defense against free radicals, iron homeostasis as well as cellular respiration and translation as central parts of the growth program.

The researchers discovered that from one stage to another, Capsaspora's suite of proteins undergoes extensive changes, and the organism uses many of the same tools as multicellular animals to regulate these cellular processes.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

As temperature changes, tree cricket ears adjust at a cellular and therefore mechanical level to match the changing frequency of the song.

Therefore, a crucial endeavor of the group is to identify biomarkers — molecular or cellular changes that can be measured fairly easily from blood — that would provide accurate information to predict whether granulomas are likely to remain latent or transition to active infection.

«While several lipid families are well - characterized at the molecular level, the total diversity and number of unique lipids in cells, how they change during cellular activation, and how they differ in individuals is unknown,» said Darley - Usmar.

AlteRNAtively, they could increase the risk of cancer by changing the way in which cells transmit genetic instructions from DNA to cellular proteins.

«What George's team has accomplished is a technological tour de force,» said Wyss Institute Founding Director Don Ingber, M.D., Ph.D. «By spotting incredibly subtle but incredibly important changes in gene expression and precisely defining their position inside the cell, they have helped open the door to a new age of cellular diagnostics.»

At a cellular and molecular level, no one really knows how the vagus nerve detects different physiological stimuli, from the stretch of the stomach after a meal to toxins that induce nausea to changes in blood pressure.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

The new enzyme converts A to a base called inosine, or I. Either a cellular repair mechanism or the process of the DNA copying itself then changes the I to a G. «The big deal here is engineering the TadA enzyme to do something fairly unnatural,» says George Church of Harvard, who studies CRISPR.

The major goals of this project are to determine the combined influences of light and gravity on plant development through the identification of changes in the mechanisms and regulation of essential cellular functions.

Systems biology provides better methods of drug discovery: research teams can measure changes in genetic activity, protein levels and cellular behavior of the immune system in response to a potential vaccine.

Random and frequent cellular deactivation of one of two gene copies could potentially change a genetic outcome

One likely place to look for an answer was histones, to see if changes in the patterns of the chemical marks on them might reveal any secrets, at the cellular level, of the aging process we all experience — and, perhaps, whether there might be anything we can do about it.

The aim of the team was to gain insights in to the molecular features of totipotency and to work out how changes in cellular plasticity may occur.

A critical next step for this work is to understand how senescent changes in late life trigger such destructive waves of cellular necrosis.