The brain, the immune system, blood — simply put, many, if not all, of the body's systems are built on the concept
of cellular diversity.
But in the study being published, researchers at the Department of Cell and Molecular Biology at Karolinska Institutet present a molecular time mechanism that can help explain neuronal stem cell regulation and therefore also the occurrence
of cellular diversity in the brain.
Not exact matches
Proteins are fundamental macromolecules for life, with a
diversity of functions, like acting as channels through
cellular walls, catalysers, DNA benders, etc..
The aim
of the Blue Brain Project is to build a replica
of a neocortical column, the basic functional unit that makes up the cerebral neocortex while encompassing most
of the neocortex's
cellular diversity.
«While several lipid families are well - characterized at the molecular level, the total
diversity and number
of unique lipids in cells, how they change during
cellular activation, and how they differ in individuals is unknown,» said Darley - Usmar.
«ImmunoMap gives scientists a picture
of the wide
diversity of the immune system's responses to
cellular antigens,» says Jonathan Schneck, M.D., Ph.D., professor
of pathology, medicine and oncology at the Johns Hopkins University School
of Medicine, and a member
of the Johns Hopkins Kimmel Cancer Center.
Presently, human pluripotent stem cells (hPSCs) are the most powerful
cellular resource to challenge this complete reassessment
of the scientific bases and goals
of toxicity testing, since they present a unique opportunity to develop a wide variety
of human cell - based physiological test systems because they may be expanded indefinitely and triggered to differentiate into any cell type, offering additionally the possibility to represent the human population
diversity.
«Our data suggest that R - NSCs may represent the first neural cell type capable
of recreating the full
cellular diversity of the mammalian nervous system.
Current in vitro hematopoiesis models fail to demonstrate the
cellular diversity and complex functions
of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live animals.
The complex networks, interactions, and responses
of immune cells produce diverse
cellular ecosystems composed
of multiple cell types, accompanied by genetic
diversity in antigen receptors.
Alternative splicing is commonly believed to be a major source
of cellular protein
diversity.