Sentences with phrase «of cellular dysfunction»

But chronic inflammation — a danger signal blaring indefinitely — can lead to all manner of cellular dysfunction, contributing to many degenerative diseases.

Not exact matches

During this clinically silent period, however, there may be indicators of dysfunction on a cellular level, such as the elevated levels of S100B antibody found in the cerebral spinal fluid in the football players in the study, even six months after the end of the season, which he said, could «potentially herald -LSB--RSB- the early stages of [chronic traumatic encephalopathy] or CTE.»

One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to cellular dysfunction or cell death.

«Dysfunction of cellular powerplant shakes B - vitamin metabolism, causes genetic damage.»

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

Recent large - scale efforts have launched a new generation of studies that aim to identify the molecular and cellular characteristics of the brain and how these translate into normal brain function — or, in the case of disease, dysfunction.

In many degenerative diseases, including neurological, metabolic, genetic, and inflammatory diseases, it's thought that the accumulation of misfolded proteins leads to cellular dysfunction and death.

They found that the genetic mutation associated with Leigh's disease compromised ATP levels, and this reduction of ATP was enough to cause significant cellular dysfunction.

Despite the protection offered by the cellular environment, the integrity of DNA is continuously challenged by a variety of endogenous and exogenous agents (e.g. ultraviolet light, cigarette smoke, environmental pollution, oxidative damage, etc...) that cause DNA lesions, interfering with proper cellular functions, such as transcription, inducing premature cellular death and finally premature ageing and organs dysfunctions.

The goal of our research is to better understand the cellular and molecular mechanisms involved in neuronal and synaptic dysfunctions characterizing neuropsychiatric diseases.

We will seek investigators that span a range of metabolism expertise, with an emphasis on interdisciplinary and collaborative - minded researchers passionate about exploring the basic molecular and mechanistic underpinnings of cellular metabolism and its dysfunction in human disease.

Low levels of the naturally occurring protein progranulin exacerbate cellular and cognitive dysfunction, while raising levels can prevent abnormalities in an Alzheimer model

We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching > 15 % of all cells in very old individuals.

These data indicate that cellular senescence is causally implicated in generating age - related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.

SAN FRANCISCO, CA — A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria — the brain's cellular power plants — can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

The far more nuanced and precise data produced by single cell analyses will allow for better understanding of pancreatic islet function and dysfunction at the cellular level.

Cancer hijacks the immune system by various cellular and molecular mechanisms and dysfunction of immune system arises during the early stages of cancer and throughout progression to later aggressive stages.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

These wipes have a hazard rating of 7 and ingredients have been linked to cancer, immunotoxicity, allergies, developmental problems, reproductive toxicity, organ dysfunction, endocrine disruption and cellular changes.

Would ketosis hurt ya or help ya... Completely depends on why you're hypothyroid... for instance, if you're hypothyroid because of stress / cortisol dysfunction, then chances are your reverse T3 (rT3) has been upregulated thus displacing free T3 (at the cellular level) in an effort to slow you down and get you recovered.

Increasing attention is being paid to mitochondrial dysfunction as a contributor to many diseases because these organelles lie at the cross roads of sensing and integrating cues from the environment to trigger adaptive and compensatory cellular responses.

Over the course of your lifetime free radical damage tends to accumulate, and scientists theorize that this accumulated damage contributes to cellular dysfunction and ultimately to declining health as we age, and is thought to be a significant part of the aging process itself.

Remember the «upstream» cause of type two diabetes is the fats in the diet which cause insulin resistance and cellular mitochondrial dysfunction.

Mitochondrial damage further drains cellular energy by creating a disproportionate need for repair, perpetuating a vicious cycle.21 Mitochondrial dysfunction can affect immunity, digestion, cognition and any energy - intensive system within the body and is a key component of many chronic illnesses.

The progressive demethylation of DNA (largely due to toxin exposure) is one of the primary drivers of the aging process and eventually leads to cellular and metabolic dysfunction.

But defects of the DNA repair system in brain cells could contribute to the accumulation of potentially disruptive and toxic metabolites of cellular insult, and lead to neurological dysfunction.»

Identification and correction of these metabolic abnormalities, including leptin resistance and cellular thyroid dysfunction, can result in dramatic long term successful weight loss.

Scientists estimate that a 30 % reduction of glutathione is enough for cellular dysfunction to occur.

However, the metabolic theory of cancer proposes that some cancers are caused by a dysfunction of cellular respiration and that the restriction of glucose in the.

The end result of the hydrogenation process is a completely unnatural fat that causes dysfunction and chaos in your body on a cellular level...... your body doesn't know what to do with it.

It is usually an excess of cellular damage that isn't all that relevant in normal aging - any sort of global dysfunction in cells will tend to share high level similarities with aging, even if the damage is different.