Sentences with phrase «of cellular enzymes»

My colleagues and I first undertook to synthesize nucleic acids outside the living cell, with the help of cellular enzymes, in 1954.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

Not exact matches

The probablility of all the cellular machinery (enzymes, ion channels, RNA polymerase, anabolic and catabolic pathways, etc) just assembling out of randomn peptides and nucleic acids is infinitely small.

I went on a raw food course about 5/6 years ago and they used a masticating juicer which they said gave optimum nutrition as it gently juiced rather than breaking everything down at cellular level and destroying some of the enzymes through heat, but I know there are also juicers that do cold pressed juices.

Hemp is a great source of sulfur containing amino acids methionine and cysteine which are necessary for cellular detoxification and the production of vital enzymes.

Maximiser ® is a blend of enzymes, direct - fed microbials and nutrients designed to enhance digestibility, feed efficiency and nutrient metabolism at the rumen and cellular level.

It offers a broad collection of nutrients that revitalize the human body on a cellular level, including vitamins, minerals, amino acids, enzymes, growth factors and other phytonutrients.

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

These data demonstrate that in RNA's with very different cellular functions, there are domains with similar structural and functional properties and that there is a nucleotide in M1 RNA that affects the site of cleavage by the enzyme.

Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.

And the first thing that begins to happen is carbon dioxide builds up inside the body, and with it there is a rise in acidity; that acidity rise contributes to cellular membranes decaying and then collapsing and then digestive enzymes that were already always present in the cells begin to slosh around to the body and [it] begins a state of what's called self digestion, so the body begins to liquefy inside rather literally.

Suv39h1 is one of the main enzymes that chemically mark the irrelevant regions of DNA to be compacted by cellular machinery, but little is known about how it installs its tag.

Previous research had shown that Topisomerase II was involved in earlier cellular processes like DNA replication, and the enzyme was still detectable even during later phases of meiosis.

Less studied is the genesis of iron - sulfur clusters, the active core in enzymes that drive almost every aspect of cellular chemistry.

Schulze - Makuch and his colleagues also found evidence for enzymes that are by - products of cellular metabolism.

«First aid kit in some living organisms helps fix DNA after lengthy sun exposure: New study unveils the binding mechanisms of enzymes capable of repairing DNA damaged by UV light before any risk of cellular malfunction sets in.»

Understanding the regulation and limitation of the telomerase enzyme holds the promise of reversing telomere shortening and cellular aging with the potential to extend human lifespan and improve the health and wellness of elderly individuals.

SIK3 phosphorylates and activates a key enzyme of glucose metabolism called Glucose -6-phosphate dehydrogenase G6PD, which is an important regulator of cellular redox balance.

However, the activity of the telomerase enzyme is insufficient to completely restore the lost telomeric DNA repeats, nor to stop cellular aging.

This cycle of activation, production and stop / block goes around once a day and is also influenced by a compound called FBXL3, which flags CRY for degradation by cellular enzymes.

In situ cellular expression of enzymes provides increased stability and control of enzyme activity as compared to isolated enzymes.

A unique feature of this DREADD system not found in other methods is that it is not limited to the control of neurons — activity levels of certain enzymes in almost every tissue type can be controlled to probe mechanisms of basic cellular function.

The new enzyme converts A to a base called inosine, or I. Either a cellular repair mechanism or the process of the DNA copying itself then changes the I to a G. «The big deal here is engineering the TadA enzyme to do something fairly unnatural,» says George Church of Harvard, who studies CRISPR.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

Some of the cellular scissors that snip out beta amyloid are a group of enzymes called the presenilins (see Science, 22 October 1999, p. 650), but scientists know the presenilins have help.

The enzyme converts heme, a cellular compound that produces damaging oxygen radicals, to less harmful compounds, some of which neutralize oxygen radicals.

So they genetically engineered Xanthobacter, giving them an enzyme called a hydrogenase, which allows them to feed on H2 to make a form of cellular energy called ATP.

Researchers identified a single enzyme doing the work of a trio thought necessary to control a common cellular signaling process being pursued as a therapeutic target.

The study, published in Nature Communications today, focused on protein kinases, enzymes that are key regulators of cellular processes.

Biologists, biochemists and geneticists who need to visualize the anatomical location of cellular structure, proteins / enzymes, mRNA, and reporter genes within whole tissue are among those who can benefit from this innovative product, which can be used with light microscopy, fluorescence microscopy, confocal microscopy and single / multiphoton microscopy.

This activity is typical of both intracellular and cellular plasma membrane isoforms of this enzyme [28].

Intra-and trans - cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules.

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

The findings, reported February 12 in Nature Cell Biology, suggest that drugs that hinder the ability of the enzyme to command cellular activity might prove effective as lung cancer therapies.

My research investigates the role of a particular protein we initially thought was just a «dead» enzyme as a regulator in signal transduction cascades (cellular communication).

Each form of the enzyme appears to have different cellular roles — i.e., allows the organism to use carbon monoxide in a different way.

Cellular Studies (CEL): The study of animal cells involving the use of microscopy to study cell structure and studies investigating activity within cells such as enzyme pathways, cellular biochemistry, and synthesis pathways for DNA, RNA, and protein.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

One such system is the lysosome, a kind of cellular «incinerator» that contains the most powerful enzymes in the cell for breaking mangled molecules down into manageable pieces.

Scientists have known that, in organisms ranging in complexity from yeast to humans, different kinds of cellular stress — such as a backlog of unfolded proteins, DNA - damaging UV light, a shortage of the amino acid building blocks needed to make protein, viral infection, iron deficiency — trigger different enzymes to act downstream to switch off eIF2 alpha.

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing.

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.

These snippets trigger a natural cellular process called RNA interference, which dials down the levels of the polyphenol - degrading enzymes and prevents browning.

Furthermore, the amino acid acceleration of a key cellular anabolic reaction may indicate a link between prebiotic chemistry and the nature of the first metabolic enzymes.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Additionally, the authors tested for cellular specificity by using as a convenient experimental framework in utero electroporation of a plasmid that allowed co-expression of the PLE enzyme and of a fluorescent tag (mCherry).

Sphingosine kinase 2 (SK2) is an enzyme that synthesizes a fat - like molecule that regulates a variety of cellular properties.

The cellular localization of the polymers was confirmed by subcellular fractionation of the cells, followed by digestion with endoglycosidase H (Figure 2C and Supplemental Figure 3C), an enzyme that removes N - linked glycans still in the high mannose ER form but does not affect oligosaccharide chains after the addition of sialic acid in the Golgi apparatus.

The study that will be published in the March 21 issue of the science magazine Cell describes how insulin, through the activity of an enzyme recently described by the Freiburg research team, blocks one of the most important cellular stress regulators, a protein called SKN - 1.