Sentences with phrase «of cellular factors»

This feeding cycle stimulates the production of cellular factors such as Cyclic AMP or GMP, which stimulate hormone synthesis and fat burning during the day, as well as protein synthesis and growth during the night, respectively.

Not exact matches

The ability of biology to detail the organisation and constitution of life - forms, not just on a cellular level, but now also on a genetic and molecular level, and its description of how such factors canaffect the global behaviour of an organism, should be taken into account in the theological and philosophical discussion of free will, individual identity / personality, conscience, the soul, and other areas concerning human behaviour, especially in regard to morality.

Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR gene's promoter (a segment of DNA near the TTR gene).

It offers a broad collection of nutrients that revitalize the human body on a cellular level, including vitamins, minerals, amino acids, enzymes, growth factors and other phytonutrients.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

«But we know that the expression of these factors is inducing changes in the epigenome, and those are leading to benefits at the cellular and organismal level.»

These long - lived worms had mutations that decreased the production of a protein known as insulinlike growth factor 1 (IGF - 1), which helps drive cellular growth and division.

«A general message from these studies is that cancer cells benefit from modulating epigenetic factors like SIRT6 by acquiring the ability to override normal cellular growth control patterns,» says Mostoslavsky, an associate professor of Medicine at Harvard Medical School and an associate member at the Broad Institute.

After grounding himself in math, molecular and cellular genetics, and immunology, he embarked on a 1 - year master's project at the University of the Mediterranean (which has now gone through a merger to become Aix - Marseille University), characterizing the genetic factors associated with malaria resistance under the supervision of Pascal Rihet.

Other factors have no significant influence — even with new low - molecular weight HES solutions, cellular - level toxic effects appear just as likely, once the total mass of HES molecules is taken into account.

«This is the first time we are able to robustly follow the Ebola fusion initiation in real time, and it will allow us to look at even more aspects of the process and cellular factors involved in the future,» says Spence.

Although the genetic studies indicated that the female offspring were the result of parthenogenesis, researchers have yet to untangle the cellular factors that explain how and why this happened.

That is when studies finally convinced scientists that the minuscule RNA snippets they had taken to calling «microRNA» were regulating cellular and genetic processes throughout the human body and were critical factors in the determination of health and disease.

A previous study by Segev at the laboratory for research of molecular and cellular mechanisms, directed by Prof. Kobi Rosenblum in the Sagol Department of Neurobiology at the University of Haifa, found a connection between a genetic condition known to be a risk factor for sporadic Alzheimer's and premature aging as manifested in ongoing metabolic stress.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

Duke scientists grew two sets of cellular «miniguts» on culture dishes and stimulated them with inflammatory factors.

This factor is required for Tat trans - activation and is a substrate of an associated cellular kinase.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

«In this study, we identified a novel regulatory factor for the Golgi - ER retrograde transport and a new mechanistic connection between the physiological trafficking and the autophagic transportation of cellular material.»

Environmental factors interact with the different subgenomes to modify the transcription of their component genes and to modulate the translation of protein products and their posttranslational modification, yielding changes in protein and cellular function and metabolism, and defining an intermediate phenotype.

Noise may disrupt the body on the cellular level in a way that increases the risk of common heart disease risk factors, according to a review topic published today in the Journal of the American College of Cardiology that examined the underlying mechanisms that may lead to noise - induced heart disease.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

We discovered that 2 hours cyclic stretching increased the phosphorylation of moesin, elongation factor eEF1D and leprecan, while the phosphorylation of elongation factor eEF1B decreased after cellular stretching.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

For example, cellular reprogramming is an inefficient process because many of the target areas on the genome are covered by other proteins, like a childproof cap on a medicine bottle, which prevents the reprogramming factors from binding there.

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

Telomeres have recently emerged as a read - out of human cellular aging and their shortening actually contributes, along with other factors, to various common age - associated diseases.

This work aims to investigate, mechanistically, the molecular processes related to dysregulation of factors that normally protect the eye against oxidative stress, thus impairing RPE and photoreceptor cellular metabolism and their survival in AMD.

The cellular transcription factor NF - kB consists of two DNA - binding subunits of 50K and 65K and is believed to play an important role in stimulating transcriptional activation of HIV - 1 in latently infected T - cells

Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein.

Perhaps a universal role for localized BR biosynthesis adjacent to boundaries of developing organs is to fine - tune cellular growth response in coordination with other cell - specific growth promoting or repressing factors.

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Moreover, some scientists suggest, that the damage of the DNA and the corresponding with it «wrong proteins» is a main factor for the accumulation of «all the cellular gunk», and they suppose, that even after the removal of the «gunc», it will accumulate again if the DNA remains damaged.

Apart from the various biomedical applications of nanomaterials, especially in cancer therapy, cellular uptake of nanoparticles is a key factor in recent years for efficient drug delivery applications.

Tissues and cells are constantly bombarded by a complex array of environmental factors that can have deleterious effects on many critical cellular functions.

(9) Indeed, the degenerative aging process is by definition one in which the organism progressively accumulates damage to its cellular and molecular components over time, so any genetic or environmental factor that leads to a greater burden of such damage will bear some resemblance to the aging phenotype, irrespective of the causal origin of the defect or its relationship to «normal» aging.

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.

«We found that, for women with no affected lymph nodes, E-cadherin is the strongest prognostic factor for a poor long - term outcome,» said first author Ruth Heimann, MD, PhD, assistant professor of radiation and cellular oncology at the University of Chicago.

«This, in turn, activates another group of proteins, called ETS transcription factors, and it is this signaling relay — from Vegf to MAPKs to ETS factors — that turns on an maintains Dll4 activity, helping the arterial cells grow and gain their cellular identity over time.»

In eukaryotes, a homeobox encodes a protein domain (the homeodomain) which can bind DNA that act as part of transcription factors to switch on cascades of other genes that induce cellular differentiation by initiating the cascades of coregulated genes required to make individual tissues, organs, or body parts.

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat - Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

Impact Factor: 16.747 Issues Per Year: 12 issues per year Aims and Scope: Cell Metabolism publishes reports of novel results in metabolic biology, from molecular and cellular biology to translational studies.

The amyloidolytic response was associated with a pronounced infiltration of the amyloidoma with neutrophils and putatively involved opsonization of fibrils by the antibody, leading to cellular activation and release of proteolytic factors.

One hypothesis is that complement factor H, part of the immune system, may help clear cellular debris from the back of the eye.

Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy.

Whitehead Institute scientists report that patients whose estrogen receptor (ER)- positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes — including increased mortality.

The timing of the reprogramming and the factors required seem to vary depending on cellular context [12]--[17].