By this way, they unravelled the mechanisms
of cellular fate during developmental growth of dermal skin, and especially investigated how fibroblast of the upper and lower dermal lineages contribute to the wound healing in adult skin.
Additionally, since ribosomal RNA has been shown to have specified controlled
of cellular fate, this study provides a theoretical basis for disease therapy and neuroscience research and may lead to future advances in treating degenerative diseases or even brain cancers.
Not exact matches
The authors used a time - lapse video recording coupled to single - cell molecular analyses to study the process step - by - step and found that
fate decision is not a unique programmed event, but the result
of a very dynamic process composed
of spontaneous fluctuation and selective stabilisation
of alternative
cellular states.
After more than six years
of research, the research team led by María Soengas, head
of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the
fate of melanoma cells: at high concentrations
of RAB7,
cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation
of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.
It seems, however, that the stem cells require a bit
of cellular hand - holding to adopt their new
fate.
On the one hand, we study systems
of proteins that determine
cellular fate during spore formation in Bacillus subtilis.
The question
of how
cellular behavior is controlled is at the center
of stem cell biology, and understanding the mechanisms
of cell
fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.
The lab will be focused on the identification
of cellular and molecular events regulating hematopoietic cell
fate decisions with emphasis on DC development.
The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell -
fate determination as well as molecular mechanisms driving
cellular reprogramming
of somatic cells to induced pluripotent stage.
One source told us that the company is working on a
cellular model
of its smartwatch, which hopefully will have a better
fate than the LG Watch Urbane 2nd gen. LTE.